Heterocyclic Building Blocks-Oxazolidine

Nakamura, Shuichi published the artcileIdentification of volatile flavor components of the oil from roasted sesame seeds, Synthetic Route of 20662-83-3, the publication is Agricultural and Biological Chemistry (1989), 53(7), 1891-9, database is CAplus.

The volatile extract obtained by steam distillation of the oil from roasted sesame seeds was separated into its neutral, weakly acidic, acidic, and basic fractions. The neutral fraction was further separated by preparative TLC. All fractions were analyzed by a gas chromatograph (GC) equipped with FID and FPD, and by gas chromatog./mass spectrometry (GC/MS) and/or gas chromatog./Fourier transform-IR (GC/FT-IR) spectrometry. Two-hundred-and-twenty-one constituents were identified. One-hundred-and-forty-six of these compounds are being reported for the 1st time in the aroma of roasted sesame seeds, 7 of which were newly identified as naturally occurring flavor components. Two dithioketones, 1-methyldithio-2-propanone, and 1-methyldithio-2-butanone, are new compounds

Agricultural and Biological Chemistry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Synthetic Route of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Jouquand, Celine published the artcileEffect of added nitrogen fertilizer on pyrazines of roasted chicory, Recommanded Product: 4,5-Dimethyloxazole, the publication is Journal of the Science of Food and Agriculture (2017), 97(4), 1172-1177, database is CAplus and MEDLINE.

BACKGROUND : Coffee substitutes made of roasted chicory are affected by the formation of acrylamide whose main precursor is asparagine. One strategy for limiting the formation of acrylamide is to reduce free asparagine in the chicory roots by lessening the supply of nitrogen in the field. However, decreasing nitrogen fertilizer could affect the formation of the volatile compounds and, consequently, the sensory characteristics of the roasted chicory. The present study aimed to investigate the impact of the nitrogen supply in five com. varieties on their aroma profile. RESULTS : The addition of 120 kg ha^-1 of nitrogen fertilizer in the field resulted in a greater amount of pyrazines in the roasted chicory. Triangle tests were performed to determine the effect of the nitrogen level on the sensory quality of the five varieties. The results revealed that the chicory aroma was modified in two out of five varieties. CONCLUSION : The results of the present study suggest that a strategy aiming to limit the amount of acrylamide could affect the sensory quality of some varieties of chicory. Further acceptance tests need to be conducted to assess the effect (whether favorable or otherwise) on the sensory quality of the coffee substitutes. © 2016 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Li, Minyong published the artcileStructure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi, Product Details of C9H6BrNO, the publication is ChemMedChem (2008), 3(8), 1242-1249, database is CAplus and MEDLINE.

Quorum sensing has been implicated in the control of pathol. relevant bacterial behavior such as secretion of virulence factors, biofilm formation, sporulation, and swarming motility. The Al-2 quorum sensing pathway is found in both Gram-pos. and Gram-neg. bacteria. Therefore, antagonizing Al-2 quorum sensing is a possible approach to modifying bacterial behavior. However, efforts in developing inhibitors of Al-2-mediated quorum sensing are especially lacking. High-throughput virtual screening using the V. harveyi LuxP crystal structure identified two compounds that were found to antagonize Al-2-mediated quorum sensing in V. harveyi without cytotoxicity. The sulfone functionality of these inhibitors was identified as critical to their ability to mimic the natural ligand in their interactions with Arg215 and Arg310 of the active site.

ChemMedChem published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Khan, Anwar Arfien Md. published the artcilePositive and negative modulation of Bombyx mori adenylate cyclase by 5-phenyloxazoles: identification of Octopamine and tyramine receptor agonists, Name: 5-(4-Bromophenyl)oxazole, the publication is Archives of Insect Biochemistry and Physiology (2003), 52(1), 7-16, database is CAplus and MEDLINE.

Nineteen 5-phenyloxazoles (5POs) were examined for their ability to modulate adenylate cyclase by measuring cAMP produced in head membrane homogenates of fifth instar larvae of the silkworm Bombyx mori. Among the compounds tested, 5-(4-methoxyphenyl)oxazole and the 2,6-dichlorophenyl congener showed the highest activation of adenylate cyclase; both compounds produced approx. half the level of cAMP produced by the action of octopamine (OCT). The OCT receptor antagonists chlorpromazine, mianserin, and metoclopramide attenuated 9-stimulated cAMP production In contrast, 5-(4-hydroxyphenyl)oxazole and the 4-cyanophenyl congener attenuated both OCT-stimulated and basal cAMP production The tyramine (TYR) receptor antagonist yohimbine inhibited the neg. effect of 8. These findings indicate that the 5PO class of compounds includes both pos. and neg. modulators of adenylate cyclase in the heads of B. mori larvae, and that 9 and 8 are OCT and TYR receptor agonists, resp. These compounds might prove useful for a pharmacol. dissection of biogenic amine receptors.

Archives of Insect Biochemistry and Physiology published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Name: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Onimura, Kenjiro published the artcileAsymmetric coupling polymerizations of 2,3-dihalido-N-substituted maleimide derivatives in the presence of chiral bisoxazolines, Computed Properties of 138429-17-1, the publication is Chemistry Letters (2013), 42(4), 366-368, database is CAplus.

Yamamoto coupling polymerizations of 2,3-dihalido-N-substituted maleimides (DXRMI) were carried out using nickel catalysts. In addition, coupling reactions of 2,3-dihalido-N-cyclohexylmaleimide (DXCHMI) were performed with nickel complexes in the presence of directly coupled chiral bisoxazolines (R’box) to give optically active poly(N-substituted maleimide-2,3-diyl)s [poly(RMI)s] (sp. rotation [α]₄₃₅ = +6.0 to -34.6°). Polymers with number-average mol. weights (M_n) ranging from 270 to 36200 were obtained in 17% to quant. yields. Poly(N-cyclohexylmaleimide-2,3-diyl) [poly(CHMI)] formed with [Ni(cod)₂]R’box exhibited the largest absolute value, [α]₄₃₅ = -34.6°.

Chemistry Letters published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C14H24N2O2, Computed Properties of 138429-17-1.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Shimoda, Mitsuya published the artcileHeadspace gas analysis of volatile compounds of light and deep roasted sesame seed oil, Application In Synthesis of 20662-83-3, the publication is Food Science and Technology International, Tokyo (1998), 4(1), 14-17, database is CAplus.

Volatile compounds in the headspace gas of light and deep roasted sesame seed oil were analyzed by gas chromatog. and gas chromatog.-mass spectrometry. The present method resulted in good reproducibility (<6.6% as a relative standard deviation) in the determination of individual volatile components. About 64 compounds, including 30 heterocyclic compounds, 7 aliphatic aldehydes, 11 ketones, and 16 miscellaneous compounds, were identified. Peak area percentages of 2-methylpropanal, 2-butenal, 2- and 3-methylbutanal, 2-propanone, 2-butanone, 3-methyl-2-butanone, 2,3-butanedione, 2- and 3-methylfuran, and 2,5-dimethylfuran, all of which could not be detected by steam distillation and column adsorptive concentration (previous method), increased in deep roasted oil. Hexanal decreased from 6.13% to 2.55% in deep roasted oil. Compared with the previous method, pyridine, thiophenes, and sulfides could be detected only by the present method, but unsaturated aliphatic aldehydes could not.

Food Science and Technology International, Tokyo published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H5ClO2, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Whitfield, Frank B. published the artcileHeterocyclic Volatiles Formed by Heating Cysteine or Hydrogen Sulfide with 4-Hydroxy-5-methyl-3(2H)-furanone at pH 6.5, SDS of cas: 20662-83-3, the publication is Journal of Agricultural and Food Chemistry (2001), 49(2), 816-822, database is CAplus and MEDLINE.

The reaction of 4-hydroxy-5-methyl-3(2H)-furanone (HMF) with cysteine or H₂S at pH 6.5 for 60 min at 140 °C produced complex mixtures of volatile compounds, the majority of these containing either sulfur or nitrogen. Of the 68 compounds detected, 63 were identified, some tentatively, by GC-MS. Among the identified compounds were thiophenes (10), thiophenones (6), thienothiophenes (5), thiazoles (5), trithiolanes (4), pyrazines (6), and oxazoles (4). More compounds were produced in the reaction of HMF with cysteine (63) than were formed in the reaction with hydrogen sulfide (33). In both systems, thiophenones were the major reaction products, accounting for 25-36% of the total volatiles formed. Possible reasons for the differences in the composition of the 2 systems are discussed. The contributions of these reactions, and their products, to the flavor of heated foods are considered.

Journal of Agricultural and Food Chemistry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C11H15NOS, SDS of cas: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Takahashi, K. published the artcileStructure of oxazolomycin, a new β-lactone antibiotic, Quality Control of 72571-06-3, the publication is Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1983), 189-96, database is CAplus.

Oxazolomycin (I) [89808-64-0] is a new antitumor antibiotic isolated from Streptomyces sp. (Y-32026). The structural elucidation of this noncrystalline antibiotic has been carried out. Its structure has been determined as I on the basis of spectral anal., x-ray crystallog. anal. and the synthesis of corresponding degraded products. The structure-biol. activity relationship was also studied. In vitro direct cytotoxicity of oxazole derivatives and each segment of oxazolomycin were examined

Tennen Yuki Kagobutsu Toronkai Koen Yoshishu published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C6H12N2O, Quality Control of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Boger, Dale L. published the artcileDiscovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics, Recommanded Product: 4,5-Dimethyloxazole, the publication is Journal of Medicinal Chemistry (2005), 48(6), 1849-1856, database is CAplus and MEDLINE.

Fatty acid amide hydrolase (FAAH) degrades neuromodulating fatty acid amides including anandamide (endogenous cannabinoid agonist) and oleamide (sleep-inducing lipid) at their sites of action and is intimately involved in their regulation. Herein the authors report the discovery of a potent, selective, and efficacious class of reversible FAAH inhibitors that produce analgesia in animal models validating a new therapeutic target for pain intervention. Key to the useful inhibitor discovery was the routine implementation of a proteomics-wide selectivity screen against the serine hydrolase superfamily ensuring selectivity for FAAH coupled with systematic in vivo examinations of candidate inhibitors.

Journal of Medicinal Chemistry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ukaji, Yutaka published the artcileAsymmetric bis(alkoxycarbonylation) reaction of homoallylic alcohols catalyzed by palladium in the presence of Cu(I) triflate using the chiral bioxazoline ligand, HPLC of Formula: 138429-17-1, the publication is Bulletin of the Chemical Society of Japan (1996), 69(3), 735-42, database is CAplus.

Palladium-catalyzed asym. intra- and intermol. bis(alkoxycarbonylation) reactions of homoallylic alcs. in the presence of copper(I) triflate were achieved by using the chiral bioxazoline ligand, (S,S)-4,4′-bis(phenylmethyl)-4,4′,5,5′-tetrahydro-2,2′-bioxazole, under normal pressure of carbon monoxide and oxygen at 25 °C to give the corresponding optically active γ-butyrolactones in 19-65% ee. For example, the allyl palladiumchloride dimer-catalyzed alkoxycarbonylation of 1-(2-propenyl)cyclohexanol (I) in the presence of trifluoromethanesulfonic acid copper(1+) salt (benzene solvate) and [S-(R*,R*)]-4,4′,5,5′-tetrahydro-4,4′-bis(phenylmethyl)-2,2-bioxazole in THF gave (S)-2-oxo-1-oxaspiro[4.5]decane-3-acetic acid Me ester (II) in 57% yield and in 65% enantiomeric excess.

Bulletin of the Chemical Society of Japan published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C4H6BrFO2, HPLC of Formula: 138429-17-1.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem