Heterocyclic Building Blocks-Oxazolidine

Chemistry is an experimental science, Computed Properties of C12H12N2O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, belongs to oxazolidines compound. In a document, author is Cruz-Hurtado, Marycarmen.

In vitro phase I metabolism of vinclozolin by human liver microsomes

1. Vinclozolin (Vin) is a fungicide used in agricultural settings and is classified as an endocrine disruptor. Vin is non-enzymatically hydrolyzed to 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1) and 3′,5′-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2) metabolites. There is no information about Vin biotransformation in humans, therefore, the aim of this study was to characterize its in vitro metabolism using human liver microsomes. 2. Vin was metabolized to the [3-(3,5-dichlorophenyl)-5-methyl-5-(1,2-dihydroxyethyl)-1,3-oxazolidine-2,4-dione] (M4) and N-(2,3,4-trihydroxy-2-methyl-1-oxo)-3,5-dichlorophenyl-1-carbamic acid (M7) metabolites, which are unstable and gradually converted to 3 ‘,5 ‘-dichloro-2,3,4-trihydroxy-2-methylbutyranilide (DTMBA, formerly denoted as M5). M4 and DTMBA metabolites co-eluted in the same HPLC peak; this co-elute peak exhibited a Michaelis-Menten kinetic, whereas M7 showed a substrate inhibition kinetics. The K-M app for co-eluted M4/DTMBA and M7 was 24.2 +/- 5.6 and 116.0 +/- 52.6 mu M, the V-Max app was 0.280 +/- 0.015 and 0.180 +/- 0.060 nmoles/min/mg protein, and the CLint app was 11.5 and 1.5 mL/min/g protein, respectively. The K-i for M7 was 133.2 +/- 63.9 mu M. Cytochrome P450 (CYP) chemical inhibitors furafylline (CYP1A2), ketoconazole (CYP3A4), pilocarpine (CYP2A6) and sulfaphenazole (CYP2C9) inhibited M4/DTMBA and M7 formation, suggesting that Vin is metabolized in humans by CYP. 3. DTMBA is a stable metabolite and specific of Vin, therefore, it could be used as a biomarker of Vin exposure in humans to perform epidemiological studies.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: C12H12N2O2, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, in an article , author is Na, Sang-Yun, once mentioned of 34052-90-9.

Fused oxazolidine-based dual optical probe for galactosidase with a dramatic chromogenic and fluorescence turn-on effect

A dual optical probe based on a fused oxazolidinoindocyanine moiety was prepared for detection of beta-galactosidase in the biological condition. The probe displayed both a dramatic colorless-to-red optical change and a fluorescence turn-on response in the visible region, exhibiting a high sensitivity for beta-galactosidase with a very low limit of detection (LOD = 0.071 U/L) in neutral PBS buffer. Published by Elsevier Ltd.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 34052-90-9, you can contact me at any time and look forward to more communication. COA of Formula: C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry, like all the natural sciences, Name: (S)-4-Phenyloxazolidin-2-one, begins with the direct observation of nature¡ª in this case, of matter.99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, SMILES is [C@H]1(NC(OC1)=O)C2=CC=CC=C2, belongs to oxazolidines compound. In a document, author is Sawant-Basak, Aarti, introduce the new discover.

Metabolism of a Serotonin-4 Receptor Partial Agonist 4-{4-[4-Tetrahydrofuran-3-yloxy)-Benzo[d]Isoxazol-3-yloxymethyl]-Piperidin-1-ylmethyl}-Tetrahydropyran-4-ol (TBPT): Identification of an Unusual Pharmacologically Active Cyclized Oxazolidine Metabolite in Human

4-{4-[4-Tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (PF-4995274, TBPT) is a new agent that is a partial agonist of the human serotonin-4 (5-HT4) receptor and is under investigation for neurological disorders. Metabolism of TBPT was examined in vitro in human liver microsomes and human hepatocytes. Metabolites were also identified in the plasma of healthy human subjects in a phase 1 clinical study. Human-derived metabolite profiles were compared with corresponding profiles obtained in laboratory animal species. There were two major routes of metabolism in vitro: N-dealkylation of the methyltetrahydropyran moiety (M1) and hydroxylation at the seven position of the benzisoxazole moiety (M4). These were also observed in human plasma; however, in that matrix, the major metabolite was an unusual cyclized oxazolidine entity (M2). M2 was proposed to be formed via generation of an intermediate 4. iminium ion on the piperidine ring followed by spontaneous cyclization by attack of the beta-hydroxyl substituent of the tetrahydropyran ring to form a cyclized oxazolidine product. An authentic standard of the metabolite was generated using a methylene-blue-sensitized photochemical oxidation reaction as well as microbial transformation. Further investigation of this metabolite showed that it also possessed 5-HT4 agonism activity similar to the parent. The metabolite was 150-fold more highly protein bound in human plasma than TBPT, which is consistent with its presence as a major circulating metabolite while being only a minor metabolite in in vitro systems. Overall, this illustrates the importance of understanding the complex dispositional properties of a pharmacologically active metabolite. (C) 2013 Wiley Periodicals, Inc.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 99395-88-7. Name: (S)-4-Phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Synthetic Route of 90319-52-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a article, author is He, Shengjie, introduce new discover of the category.

Synthesis of fused tetracyclic benzo[4,5]furo[3,2-d]pyrimidin-4(3H)-ones derivatives containing thiadiazole/oxazolidine/triazole/triazinanone moieties

In an attempt to design and synthesize new heterocycles with improved their biological properties, some of fused tetracyclic benzo[4,5]furo[3,2-d]pyrimidin- 4(3H)-ones bearing 1,2,4-triazole, 1,3,4-thiadiazole, 1,2,4-triazinanone, and oxazolidine systems have been prepared by the aza-Wittig reactions from readily available starting material under mild conditions. The structure of synthesized compounds was elucidated by(1)H NMR,C-13 NMR, MS, IR, and elemental analysis.

Synthetic Route of 90319-52-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 90319-52-1.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, SMILES is [C@H]1(NC(OC1)=O)C2=CC=CC=C2, in an article , author is Ciaccio, James A., once mentioned of 99395-88-7, Recommanded Product: 99395-88-7.

Probing the Reactivity of Cyclic N,O-Acetals versus Cyclic O,O-Acetals with NaBH4 and CH3MgI

An operationally straightforward, project-like laboratory experiment has been developed in which students directly compare the reactivity of two heterocycles, a cyclic O,O-acetal (standard C=0 protecting group) and a cyclic N,O-acetal (oxazolidine), toward sodium borohydride and methylmagnesium iodide. Students synthesize a substrate containing both structural features, and then experimentally establish the chemo- and regioselective ring-opening of the N,O-acetal by identifying their 2-amino-l-alkanol products through spectral analysis. This experiment demonstrates that nonaromatic N- and O-heterocycles beyond those usually encountered by students in introductory organic textbooks, such as O,O-acetals and epoxides, are also reactive to nucleophiles, and it emphasizes the great effect on chemical reactivity of a seemingly minor structural alteration: exchanging 0 for N in a heterocycle.

Interested yet? Read on for other articles about 99395-88-7, you can contact me at any time and look forward to more communication. Recommanded Product: 99395-88-7.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 84793-24-8, Name is Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate, molecular formula is C16H19NO5, belongs to oxazolidines compound. In a document, author is Qi, Qingkai, introduce the new discover, Name: Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate.

Intracellular pH sensing using polymeric micelle containing tetraphenylethylene-oxazolidine

A novel amphiphilic copolymer consisting of tetraphenylethylene-oxazolidine (TPE-OX) as a pH-sensitive chromophore and poly(ethylene glycol) methyl ether methacrylate (PEGMA) as a water-soluble chain has been well designed and synthesized. A self-assembled polymeric micelle based on the copolymer exhibited clear dual-emission switching between cyan and red with a decrease of pH value in Tris-HCl buffer solution due to the extended conjugation and emerging intramolecular charge transfer effect when opening the spiro-ring of OX moiety. Fluorescence imaging of HepG2 cells stained by the polymeric micelle shows switched luminescence from cyan to red with high selectivity and contrast, indicating that the polymeric micelle was an effective probe for intracellular pH detection. Additionally, the red emission of the polymeric micelle in lysosomes can reversibly switch back to the original cyan emission in response to the two lysosomal activity inhibitors chloroquine and bafilomycin, which demonstrates that the polymeric micelle has potential applications in detecting the activity of lysosomal and further autophagy in cancer cells.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 84793-24-8. Name: Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 6704-31-0, Name is Oxetan-3-one, SMILES is O1CC(C1)=O, in an article , author is Chahen, Ludovic, once mentioned of 6704-31-0, SDS of cas: 6704-31-0.

Comprehensive monitoring of MEA degradation in a post-combustion CO2 capture pilot plant with identification of novel degradation products in gaseous effluents

A pilot plant campaign was performed to study MEA degradation in CO2 capture conditions and anticipate potential degradation products emissions to the atmosphere in industrial case. Aqueous 30% wt MEA was cycled between absorption and regeneration steps during 1700 h in the presence of a synthetic flue gas containing 81% of N-2,14% of CO2, 5% of 02,97 ppm of NO, 9 ppm of SO2 and 5 ppm of NO2. Specific methods (sampling, sample conditioning and analysis) were developed to improve degradation products identification and to provide a quantification of targeted compounds in liquid phase and above all in absorber and stripper gas effluents. Especially, trace elements were detected in liquid phase thanks to Head Space Solid Phase MicroExtraction (HS-SPME) and liquid-liquid extraction with ChemElut cartridges and in gas phase thanks to adsorbent tubes of different type: Sep-Pak for aldehydes and ketones, Orbo 60 for N-nitrosodimethylamine, Tenax and active charcoal for non-specific adsorption. 32 degradation products were identified in liquid phase and 38 in gas phase, 17 of which for the first time, especially derivatives of pyridine and oxazolidine, 1H-pyrrole and a new nitrosamine, the N-nitroso-2-methyl-oxazolidine. (C) 2016 Elsevier Ltd. All rights reserved.

Interested yet? Read on for other articles about 6704-31-0, you can contact me at any time and look forward to more communication. SDS of cas: 6704-31-0.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C10H11NO2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, molecular formula is C10H11NO2. In an article, author is Jacobsen, Eric,once mentioned of 16251-45-9.

A mixed anhydride approach to the preparation of sulfinate esters and allylic sulfones: Trimethylacetic p-toluenesulfinic anhydride

A reagent combination of toluenesulfinic acid and trimethylacetyl chloride affords a putative trimethylacetic p-toluenesulfinic anhydride. This reagent has been used to prepare a series of sulfinate esters from primary and secondary alcohols. In addition, the reagent was used to convert Baylis-Hillman substrates into allylic sulfones. Attempts to use the reagent to convert amines to sulfinamides were unsuccessful. In contrast, the use of 2-pyrrolidinone afforded N-p-toluenesulfinyl pyrrolidinone in 64% yield. The use of a chiral 4-benzy1-1,3-oxazolidinone or 4-benzyl-1,3-oxazolidine-2-thione led to the isolation of S-p-tolyl ptoluenethiosulfonate. (C) 2017 Elsevier Ltd. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C3H4O2, 6704-31-0, Name is Oxetan-3-one, SMILES is O1CC(C1)=O, in an article , author is Xiong, Wei, once mentioned of 6704-31-0.

Pd-Catalyzed Decarboxylative Cycloaddition of Vinylethylene Carbonates with Isothiocyanates

An efficient route for formal [3 + 2] cycloaddition of vinylethylene carbonates with isothiocyanates was developed for the synthesis of 1,3-oxazolidine-2-thione derivatives. The zwitter-ionic pi-allyl palladium intermediates formed in situ by decarboxylation of VECs acted as the three-membered synthons. In this transformation, the C-N bond formation was selectively realized over the C-S bond formation.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 6704-31-0, you can contact me at any time and look forward to more communication. Computed Properties of C3H4O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, SMILES is [C@H]1(NC(OC1)=O)C2=CC=CC=C2, belongs to oxazolidines compound. In a document, author is Ol’khovik, V. K., introduce the new discover, Recommanded Product: 99395-88-7.

New luminescent dyes from the series of 1,3,7-substituted dibenzothiophene-5,5-diones

Preparation method was developed and a series of new linear polyconjugated compounds was obtained with (1,3-benzoxazol-2-yl)ethenyl, (5-oxo-2-phenyl-1,3-oxazolidine)methyl moieties in the positions 3, 7 of dibenzothiophene-5,5-dione frame and with peripheral alkoxy- and alkylamine substituents in the position 1. Compounds obtained possess a strong luminescence in solutions, in the solid state, and exhibit electroluminescent properties.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 99395-88-7 is helpful to your research. Recommanded Product: 99395-88-7.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem