Heterocyclic Building Blocks-Oxazolidine

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 6704-31-0, Name is Oxetan-3-one, formurla is C3H4O2. In a document, author is Pal’chikov, V. A., introducing its new discovery. Recommanded Product: 6704-31-0.

2-(4-nitrophenyl)oxirane amino derivatives in heterocyclization reactions

Reactions of 2-amino-1-(4-nitrophenyl)ethanol with various electrophilic reagents led to the formation of oxazaheterocycles (1,3-oxazolidin-2-one, 1,3-oxazolidine, morpholin-2-, -3-one, and -2,3-dione). In reactions of 2-{(bicyclo[2.2.1]hept-5-en-2-ylmethyl)amino}-1-(4-nitrophenyl)ethan-1-ol with carbonyldiimidazole, oxalyl chloride, benzaldehyde, and formaldehyde the corresponding derivatives of 1,3-oxazolidin-2- one, morpholin-2,3-dione, and 1,3-oxazolidine were obtained.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2. In an article, author is Lu, C. F.,once mentioned of 90319-52-1, COA of Formula: C9H9NO2.

Asymmetric synthesis of (S)-2-sec-Butyl-4,5-dihydrothiazole, a pheromone component of the Mus musculus

The asymmetric synthesis of (S)-2-sec-butyl-4,5-dihydrothiazole, one of the pheromone components of the male mouse, Mus musculus, has been achieved by induction of chirality through stereoselective alkylation reaction using non-cross-linked polystyrene (NCPS) supported 2-phenylimino-2-oxazolidine as a chiral auxiliary. This method is efficient, and the chiral auxiliary can be recovered by simple filtration. The final product was obtained in 91% ee and 23% overall yield.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Reference of 16251-45-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, SMILES is O=C1O[C@H](C2=CC=CC=C2)[C@H](C)N1, belongs to oxazolidines compound. In a article, author is Bouzian, Younos, introduce new discover of the category.

Crystal structure, Hirshfeld surface analysis, DFT and molecular docking investigation of 2-(2-oxo-1,3-oxazolidin-3-yl)ethyl 2-[2-(2-oxo-1,3-oxazolidin-3-yl)ethoxy]quinoline-4-carboxylate

In the molecular structure of the title compound, C20H21N3O7, the quinoline ring system is slightly bent, with a dihedral angle between the phenyl and the pyridine rings of 3.47 (7)degrees. In the crystal, corrugated layers of molecules extending along the ab plane are generated by C-H center dot center dot center dot O hydrogen bonds. The intermolecular interactions were quantified by Hirshfeld surface analysis and two-dimensional fingerprint plots. The most significant contributions to the crystal packing are from H center dot center dot center dot H (42.3%), H center dot center dot center dot O/O center dot center dot center dot H (34.5%) and H center dot center dot center dot C/C center dot center dot center dot H (17.6%) contacts. Molecular orbital calculations providing electron-density plots of the HOMO and LUMO as well as molecular electrostatic potentials (MEP) were computed, both with the DFT/B3LYP/6-311 G++(d,p) basis set. A molecular docking study between the title molecule and the COVID-19 main protease (PDB ID: 6LU7) was performed, showing that it is a good agent because of its affinity and ability to adhere to the active sites of the protein.

Reference of 16251-45-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 16251-45-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

In an article, author is Aminto, Alison, once mentioned the application of 34052-90-9, Computed Properties of C12H12N2O2, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, molecular weight is 216.24, MDL number is MFCD00191606, category is oxazolidines. Now introduce a scientific discovery about this category.

Four-compartment partition model of hazardous components in hydraulic fracturing fluid additives

Mass balance principles were applied to a four-compartment partition model for 12 different hazardous components of hydraulic fracturing fluid additives used in 47 completed natural gas wells in the Marcellus Shale. Spill scenarios were modeled as if 1000 gallons of diluted additive were discharged into a surface water body or onto soil. Resulting concentrations were ranked according to magnitude, providing a relative comparison of quantities to be expected in each compartment. Highest mass concentrations in the water, soil and biota compartments were due to sodium hydroxide, 4,4-dimethyl oxazolidine, and hydrochloric acid. 4,4-dimethyl oxazolidine ranked highest in the air compartment. (C) 2012 Elsevier B.V. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Application of 99395-88-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, SMILES is [C@H]1(NC(OC1)=O)C2=CC=CC=C2, belongs to oxazolidines compound. In a article, author is Sangthong, Sarita, introduce new discover of the category.

High-accuracy mass spectrometry for identification of sulphur containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)

The bioactive compounds of Raphanus sativus var. caudatus Alef and their respective cytotoxicity were identified from (a) 2 crude water and dichloromethane extracts and (b) 5 serially partitioned extracts using dichloromethane. Then, using a bioassay-guided cytotoxicity assay, the extracts were tested against the colon cancer cell line HCT116. Among 2 crude extracts and 5 fractions, the dichloromethane crude extract possessed the greatest in vitro cytotoxicity against HCT116. The dichloromethane crude extract was subjected to flash column liquid chromatography. Only 4 fractions and unfractionated extract were chosen for further analysis by high accuracy mass spectrometry (UHPLC-QToF-MS/MS). Six glucosinolates, 13 isothiocyanates, 5 indoles, 4 flavonoids, 2 alkaloids, 2 thiocyanates, 1 oxazolidine, and 1 dialkyl disulphide were identified. Two compounds were detected for the first time isoalliin and butyl 1-(methylthio)propyl disulphide. Several constituents with anti-cancer activity were identified. This information could inform guidelines for quality control of standard plant extracts for further product development.(C) 2017 Elsevier Ltd. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 84793-24-8, Name is Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate, molecular formula is C16H19NO5. In an article, author is Goncalves, Raoni S. B.,once mentioned of 84793-24-8, Quality Control of Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate.

Crystal structures of mefloquine-oxazolidine derivatives, 4-[3-(halophenyl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]2,8-bis(trifluoromethyl)quinolines

Crystal structures are reported for five racemic 4-{3-(halophenyl)hexahydro[1,3]oxazolo [3,4-a]pyridin-1- yl)-2,8-bis(triffuoromethyl)quinolines, 2, namely (2: X = 2-F, 3-Br, 4-C1 4-Br and 4-F), prepared from metloquine and XC6H5CHO. In each case, the compound crystallizes in the triclinic space group. P (1) over bar, with Z = 2. All molecules have F shapes with the X-phenyl and quinoline rings lying on one side of the best plane through the fused oxazolidinc-piperidine rings. Differences in the conformations of the molecules are indicated by the differences in the interplanar angles. In each case, the supramolecular arrangements are made up from combinations of a a and some of C-H X and C-X pi (X = halo) interactions. Two similar structural sub-sets found in the crystal structures of the five derivatives are centrosymmetric a-linked dimers and centrosvmmetric cage-like dimers. The cage-like dimers, formed by the intermeshing of the rings of the monomers, are generated from different weak intermolecular interactions, which include C-H… X and C-X (X = halo) interactions. Comparisons are made between the activities of the mefloquine-oxazolidine derivatives in in-vitro tests against the multidrug-resistant tuberculosis strain and conformations, as measured by interplanar angles.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

In an article, author is Castet, Frederic, once mentioned the application of 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, molecular weight is 163.1733, MDL number is MFCD00043396, category is oxazolidines. Now introduce a scientific discovery about this category, Name: (S)-4-Phenyloxazolidin-2-one.

Design and Characterization of Molecular Nonlinear Optical Switches

Nanoscale structures, including molecules, supramolecules, polymers, functionalized surfaces, and crystalline/amorphous solids, can commute between two or more forms, displaying contrasts in their nonlinear optical (NLO) properties. Because of this property, they have high potential for applications in data storage, signal processing, and sensing. As potential candidates for integration into responsive materials, scientists have been intensely studying organic and organometallic molecules with switchable first hyperpolarizability over the past two decades. As a result of this, researchers have been able to synthesize and characterize several families of molecular NW switches that differ by the stimulus used to trigger the commutation. These stimuli can indude light irradiation, pH variation, redox reaction, and ion recognition, among others. The design of multistate (including several switchable units) and multifunctional (triggered with different stimuli) systems has also motivated a large amount of work, aiming at the improvement of the storage capacity of optical memories or the diversification of the addressability of the devices. In complement to the synthesis of the compounds and the characterization of their NLO responses by means of hyper-Rayleigh scattering, quantum chemical calculations play a key role in the design of molecular switches with high first hyperpolarizability contrasts. Through the latter, we can gain a fundamental understanding of the various factors governing the efficiency of the switches. These are not easily accessible experimentally, and include donor/acceptor contributions, frequency dispersion, and solvent effects. In this Account, we illustrate the similarities of the experimental and theoretical tools to design and characterize highly effident NLO switches but also the difficulties in comparing them. After providing a critical overview of the different theoretical approaches used for evaluating the first hyperpolarizabilities, we report two case studies in which theoretical simulations have provided guidelines to design NLO switches with improved efficiencies. The first example presents the joint theoretical/experimental characterization of a new family of multi-addressable NLO switches based on benzazolo-oxazolidine derivatives. The second focuses on the photoinduced commutation in merocyanine spiropyran systems, where the significant NLO contrast could be exploited for metal cation identification in a new generation of multiusage sensing devices. Finally, we illustrate the impact of environment on the NLO switching properties, with examples based on the keto-enol equilibrium in anil derivatives. Through these representative examples, we demonstrate that the rational design of molecular NLO switches, which combines experimental and theoretical approaches, has reached maturity. Future challenges consist in extending the investigated objects to supramolecular architectures involving several NLO-responsive units, in order to exploit their cooperative effects for enhancing the NLO responses and contrasts.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 34052-90-9, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, in an article , author is Song, Xiaoxiao, once mentioned of 34052-90-9.

Highly Stereoselective Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Epoxides and N-Benzothiazolimines

An asymmetric [3+2] cycloaddition of racemic vinyl epoxides with N-benzothiazolimines has been presented under Pd-catalysis. This transformation provides rapid access to highly functionalized oxazolidine scaffolds in generally good yields along with high stereoselectivities (up to 99% ee, 8.5 : 1 d.r.) under mild conditions. The use of chiral BINAP ligand enabled this asymmetric transformation with a broad substrate tolerance.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 34052-90-9, you can contact me at any time and look forward to more communication. Recommanded Product: 34052-90-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: oxazolidines, 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, molecular formula is C10H11NO2, belongs to oxazolidines compound. In a document, author is Sato, Keiichi, introduce the new discover.

Access of cis-4-monofluoromethyl-1,3-oxazolidines via a formal [3+2] cycloaddition triggered by BF3 center dot OEt2

A series of cis-4-monofluoromethyl-1,3-oxazolidines were prepared from 2-monofluoromethyl-N-tosylaziridine and various aldehydes in the presence of (BF3OEt2)-O-center dot under mild conditions. The high regioselectivity of the reaction suggested that the electron-withdrawing ability of the monofluoromethyl group is similar to that of trifluoromethyl and difluoromethyl groups in this type of cycloaddition.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 16251-45-9. Category: oxazolidines.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a document, author is Yang, Shuang, introduce the new discover, Formula: C9H9NO2.

Divergent synthesis of oxazolidines and morpholines via PhI(OAc)(2)-mediated difunctionalization of alkenes

Herein we describe the PhI(OAc)(2)-mediated 1,1- and 1,2-difunctionalization of alkenes with N-tosyl amino alcohols to form oxazolidine and morpholine derivatives. This transformation was realized under mild reaction conditions and allows application to various substrates furnishing the multi-substituted oxazolidines and morpholines with yields up to 98%. A deuterium-labeling experiment was carried out and the result indicated that a phenyl group migration occurred to generate oxazolidine products.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 90319-52-1 is helpful to your research. Formula: C9H9NO2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem