Heterocyclic Building Blocks-Oxazolidine

Oxazoline Early Transition Metal Complexes: Functionalizable Achiral Titanium(IV), Titanium(III), Zirconium(IV), Vanadium(III), and Chiral Zirconium(IV) Bis(oxazoline) Complexes was written by Cozzi, Pier Giorgio; Floriani, Carlo; Chiesi-Villa, Angiola; Rizzoli, Corrado. And the article was included in Inorganic Chemistry on May 24,1995.Formula: C11H13NO2 The following contents are mentioned in the article:

Large-scale syntheses of the (hydroxyphenyl)oxazoline ligands [I; R = R’ = Me, R” = H (L1); R = CH2Ph, R’ = R” = H (L2); R = CHMe2, R’ = R” = H (L3); R = Me, R’ = H, R” = Ph (L4); R = Ph, R’ = R” = H (L5)] are reported. The conversion of L1-L5 into the corresponding sodium salts was employed for metal complexation. The reaction of L1 with TiCl4·2THF, TiCl3·3THF, ZrCl4·2THF, and VCl3·3THF in a 1:2 metal:ligand ratio afforded the corresponding hexacoordinate functionalizable metal complexes: cis-[Cl2Ti(L1)2], 11; cis-[(THF)ClTi(L1)2], 12; cis-[Cl2Zr(L1)2], 13; trans-[(THF)ClV(L1)2], 14. The structures of 11, 12, and 14 were clarified by x-ray anal. The reaction of the L3 and L4 sodium salts with ZrCl4·2THF in a 1:2 metal:ligand ratio led to the corresponding chiral functionalizable metal complexes, whose structures were clarified by x-ray anal.: cis-[Cl2Zr(L3)2], 15; cis-[Cl2Zr(L4)2], 16. A common significant feature discovered from these studies is the existence of intramol. hydrogen bonding, which is probably responsible for the high conformational rigidity of the oxazoline ligand. Crystallog. details are as follows: 11 is monoclinic, space group I2/a, with a 16.443(2), b 8.365(1), c 17.945(2) Å, β 106.93(1)°, Z = 4, and R = 0.034; 12 is orthorhombic, space group Pca21, with a 15.669(2), b 17.750(3), c 18.971(3) Å, Z = 8, and R = 0.050; 14 is monoclinic, space group P21/n, with a 9.391(4), b 28.618(6), c 12.077(4) Å, β 105.79(2)°, Z = 4, and R = 0.052; 16 is monoclinic, space group P21, with a 10.161(2), b 14.151(3), c 12.361(2) Å, β 93.76(2)°, Z = 2, and R = 0.033. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Formula: C11H13NO2).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Formula: C11H13NO2

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Oxazoline Early Transition Metal Complexes: Functionalizable Achiral Titanium(IV), Titanium(III), Zirconium(IV), Vanadium(III), and Chiral Zirconium(IV) Bis(oxazoline) Complexes was written by Cozzi, Pier Giorgio; Floriani, Carlo; Chiesi-Villa, Angiola; Rizzoli, Corrado. And the article was included in Inorganic Chemistry on May 24,1995.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

Large-scale syntheses of the (hydroxyphenyl)oxazoline ligands [I; R = R’ = Me, R” = H (L1); R = CH2Ph, R’ = R” = H (L2); R = CHMe2, R’ = R” = H (L3); R = Me, R’ = H, R” = Ph (L4); R = Ph, R’ = R” = H (L5)] are reported. The conversion of L1-L5 into the corresponding sodium salts was employed for metal complexation. The reaction of L1 with TiCl4·2THF, TiCl3·3THF, ZrCl4·2THF, and VCl3·3THF in a 1:2 metal:ligand ratio afforded the corresponding hexacoordinate functionalizable metal complexes: cis-[Cl2Ti(L1)2], 11; cis-[(THF)ClTi(L1)2], 12; cis-[Cl2Zr(L1)2], 13; trans-[(THF)ClV(L1)2], 14. The structures of 11, 12, and 14 were clarified by x-ray anal. The reaction of the L3 and L4 sodium salts with ZrCl4·2THF in a 1:2 metal:ligand ratio led to the corresponding chiral functionalizable metal complexes, whose structures were clarified by x-ray anal.: cis-[Cl2Zr(L3)2], 15; cis-[Cl2Zr(L4)2], 16. A common significant feature discovered from these studies is the existence of intramol. hydrogen bonding, which is probably responsible for the high conformational rigidity of the oxazoline ligand. Crystallog. details are as follows: 11 is monoclinic, space group I2/a, with a 16.443(2), b 8.365(1), c 17.945(2) Å, β 106.93(1)°, Z = 4, and R = 0.034; 12 is orthorhombic, space group Pca21, with a 15.669(2), b 17.750(3), c 18.971(3) Å, Z = 8, and R = 0.050; 14 is monoclinic, space group P21/n, with a 9.391(4), b 28.618(6), c 12.077(4) Å, β 105.79(2)°, Z = 4, and R = 0.052; 16 is monoclinic, space group P21, with a 10.161(2), b 14.151(3), c 12.361(2) Å, β 93.76(2)°, Z = 2, and R = 0.033. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Syntheses and crystal structures of 4,5-dihydro-2-(2-hydroxyphenyl)oxazole-containing metal complexes was written by Bolm, Carsten; Weickhardt, Konrad; Zehnder, Margareta; Glasmacher, Dorothea. And the article was included in Helvetica Chimica Acta on June 19,1991.Formula: C13H17NO2 The following contents are mentioned in the article:

ML2 (M = Cu, HL = I (R = H, R1 = CHMe2, Ph, CMe3 or R = Ph, RI = Me); M = Zn, Co, Ni, FeCl, R = H, R1 = CHMe2) and I were prepared ML2 (M = Cu, Zn, Ni; R = H, R1 = CHMe2) were analyzed by x-ray diffraction studies [monoclinic, space group P21, A2, A2, Z = 4, 2, 2, Rw = 0.078, 0.074, 0.060, resp.]. L coordinates through the hydrooxazole N and phenolato O atoms. CuL2 and NiL2 have a distorted square planar configuration whereas ZnL2 has a distorted tetrahedral configuration. ML2 were characterized by IR and mass spectra. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Formula: C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Formula: C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Cobalt/Salox-Catalyzed Enantioselective C-H Functionalization of Arylphosphinamides was written by Yao, Qi-Jun; Chen, Jia-Hao; Song, Hong; Huang, Fan-Rui; Shi, Bing-Feng. And the article was included in Angewandte Chemie, International Edition on June 20,2022.Reference of 163165-92-2 The following contents are mentioned in the article:

Previous methods on Co(III)-catalyzed asym. C-H activation rely on the use of tailor-made cyclopentadienyl-ligated Co(III) complexes, which require lengthy steps for the preparation Herein, the authors report an unprecedented enantioselective C-H functionalization enabled by a simple Co/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcs. A broad range of P-stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99% yield and >99% ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic Co species, the action of Salox, and the mode of stereocontrol. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Reference of 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Reference of 163165-92-2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Cobalt/Salox-Catalyzed Enantioselective C-H Functionalization of Arylphosphinamides was written by Yao, Qi-Jun; Chen, Jia-Hao; Song, Hong; Huang, Fan-Rui; Shi, Bing-Feng. And the article was included in Angewandte Chemie, International Edition on June 20,2022.Synthetic Route of C13H17NO2 The following contents are mentioned in the article:

Previous methods on Co(III)-catalyzed asym. C-H activation rely on the use of tailor-made cyclopentadienyl-ligated Co(III) complexes, which require lengthy steps for the preparation Herein, the authors report an unprecedented enantioselective C-H functionalization enabled by a simple Co/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcs. A broad range of P-stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99% yield and >99% ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic Co species, the action of Salox, and the mode of stereocontrol. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Synthetic Route of C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Synthetic Route of C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Chiral-at-Iron Catalyst for Highly Enantioselective and Diastereoselective Hetero-Diels-Alder Reaction was written by Hong, Yubiao; Cui, Tianjiao; Ivlev, Sergei; Xie, Xiulan; Meggers, Eric. And the article was included in Chemistry – A European Journal on June 10,2021.Formula: C12H15NO2 The following contents are mentioned in the article:

This study demonstrates that chiral-at-iron complexes, in which all coordinated ligands are achiral and the overall chirality the consequence of a stereogenic iron center, are capable of catalyzing asym. transformations with very high enantioselectivities. The catalyst is based on a previously reported design (J. Am. Chem. Soc. 2017, 139, 4322), in which iron(II) is surrounded by two configurationally inert achiral bidentate N-(2-pyridyl)-substituted N-heterocyclic carbenes in a C2-sym. fashion and complemented by two labile acetonitriles. By replacing mesityl with more bulky 2,6-diisopropylphenyl substituents at the NHC ligands, the steric hindrance at the catalytic site was increased, thereby providing a markedly improved asym. induction. The new chiral-at-iron catalyst was applied to the inverse electron demand hetero-Diels-Alder reaction between β,γ-unsaturated α-ketoester and enol ethers provide 3,4-dihydro-2H-pyrans in high yields with excellent diastereoselectivities (up to 99 : 1 dr) and excellent enantioselectivities (up to 98% ee). Other electron rich dienophiles are also suitable as demonstrated for a reaction with a vinyl azide. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Formula: C12H15NO2).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Formula: C12H15NO2

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Remarkable reversal of the non-linear effect in the catalytic enantioselective allylic oxidation of cyclohexene using copper proline complexes and t-butyl hydroperoxide was written by Zondervan, Charon; Feringa, Ben L.. And the article was included in Tetrahedron: Asymmetry on July 12,1996.Product Details of 163165-92-2 The following contents are mentioned in the article:

Several examples of efficient catalytic conversions of cyclohexene to optically active 2-cyclohexenyl propionate are reported using t-Bu hydroperoxide as oxidant. With the bis-(S)-prolinato copper(II) complex enantioselectivities up to 63% with good conversions were obtained. A neg. non-linear ligand effect was observed Addition of catalytic amounts of anthraquinone resulted in a higher enantioselectivity as well as a reversal of the non-linear effect. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Product Details of 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Product Details of 163165-92-2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores was written by Goebel, Dominik; Clamor, Nils; Lork, Enno; Nachtsheim, Boris J.. And the article was included in Organic Letters on July 19,2019.Category: oxazolidine The following contents are mentioned in the article:

The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl·LiCl and subsequent oxidation with mol. oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramol. proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic mols. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Category: oxazolidine).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Category: oxazolidine

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Chiral-Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes was written by Gong, Lei; Mulcahy, Seann P.; Harms, Klaus; Meggers, Eric. And the article was included in Journal of the American Chemical Society on July 22,2009.Related Products of 1045894-43-6 The following contents are mentioned in the article:

A strategy for the asym. synthesis of chiral-at-metal [Ru(pp)(pp’)(pp”)]+ complexes (Hpp = isopropyl-2-(2′-hydroxyphenyl)oxazoline, pp’ and pp” = achiral 2,2′-bipyridine, 5,5′-dimethyl- and 4,4′-di-tert-butyl-2,2′-bipyridine), is reported. The method employs isopropyl-2-(2′-hydroxyphenyl)oxazolines as chiral auxiliaries, which serve in their deprotonated forms as strong bidentate ligands that provide excellent asym. induction in the coordination chem. and, importantly, can afterward become substituted with complete retention of configuration in the presence of acid. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Related Products of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Related Products of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Chiral Pd-, Cu- and Ni-chelates and their utilities as catalysts in allylic acetoxylation of alkenes was written by Yang, Hu; Khan, Masood A.; Nicholas, Kenneth M.. And the article was included in Journal of Molecular Catalysis on July 29,1994.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

A series of chiral ML*2 complexes of Pd, Cu and Ni [L = 2-trifluoroacetylcamphorato (tfacam), (R)-N-α-methylbenzylsalicylaldimine, 2-(2′-phenolato)-4-substituted oxazoline (phenox)] were prepared and characterized, including x-ray structures of Pd(tfacam)2 (1) and Pd(4-Ph-phenox)2 (3a). The Pd- and Cu-chelates are active (pre)catalysts for the allylic acetoxylation of alkenes. The yields and chemoselectivities in these reactions are high but little enantioselectivity (0-5%) was found. Several mechanistic probes, including tests of the stability of the product and PdL*2 under the reaction conditions, the product distribution from the acetoxylation of D-1-cyclohexene, and the low acetolysis reactivity of LPd(η3-allyl), indicate the intervention of (η3-allyl)-Pd intermediates in the catalytic process in which either or both L groups dissociate or at least dechelate in the product-forming step. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

150699-08-4;(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-08-4;New trend of C15H13NO2;function of 150699-08-4