A new application about 102029-44-7

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Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 1: Synthetic Strategy and Preparation of a Common Precursor

The synthetic strategy for producing multigram quantities of (+)-discodermolide (1) using a hybridized Novartis-Smith-Paterson synthetic route via common precursor 3 is described. In the first part of this five-part series, we present a multikilogram preparation of alpha-methyl aldehyde 10 from Roche ester, its syn-aldol reaction with Evans boron enolate, removal of the chiral auxiliary, and the preparation of Weinreb amide 3 (Smith common precursor). The common precursor was produced without any chromatography.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1930NO – PubChem

 

Simple exploration of Oxazolidin-2-one

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Electric Literature of 497-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Chapter£¬once mentioned of 497-25-6

Synthesis and ESI-MS/MS fragmentation study of two new isomeric oxazolidin-2-one derivatives

Two new isomeric oxazolidin-2-one derivatives have been synthesized through reaction of (E)-3-styrylquinoxalin-2-one with bis-dichloroethylamine hydrochloride in presence of potassium carbonate. The structures of the formed products were established by NMR and mass spectroscopy. The fragmentation patterns of the two novel synthesized oxazolidin-2-ones (1, 2), possessing the same backbone structure, were investigated using electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS) techniques. A simple methodology, based on the use of ESI (positive ion mode) and by increasing the declustering potential in the atmospheric pressure/vacuum interface, collision induced dissociation (CID), was used to enhance the formation of the fragment ions. In general, the novel synthetic oxazolidin-2-one derivatives afforded, in the gas phase, protonated molecules leading to the confirmation of the molecular masses and chemical structures of the studied compounds. The breakdown routes of the protonated molecules were rationalized by conducting low-energy collision CID-MS/MS analyses (product ion scans) using. The structural similarity between the two studied oxazolidin-2-ones explains the similarity observed in their CID-MS/MS spectra and their fragmentation pathways. ESI-MS/MS recorded with increased collision energy values permits us to observe different product ions and allow us to differentiate the two studied isomers. ESI-MS and CID-MS/MS analyses have thus proven to be a specific and very sensitive method for the structural investigation of the two novel synthesized oxazolidin-2-one derivatives.

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A new application about (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

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Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer?s Disease

Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses good in vitro potency with excellent predicted CNS drug-like properties and desirable ADME/PK profile. This lead compound demonstrated robust Abeta42 reductions and subsequent Abeta37 increases in both rodent brain and CSF at 30 mg/kg dosed orally.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2290NO – PubChem

 

Final Thoughts on Chemistry for 139009-66-8

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Application of 139009-66-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.139009-66-8, Name is (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid, molecular formula is C11H19NO5. In a Patent£¬once mentioned of 139009-66-8

DEODORANT COMPOSITIONS

The present invention relates to a deodorant composition comprising an oxazolidine- or, a thiazolidine-carboxylic acid compound, a cosmetic carrier and optionally a fragrance. The invention also relates to a manufacturing process for the deodorant composition, a method of treating malodour and a method of screening deodorant actives as well as inhibiting a Staphylococcus hominis C-S ?-lyase.

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Extended knowledge of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

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PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF EZETIMIBE

The invention relates, in general, to an improved process for the preparation of the compounds (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one and (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one, which are key intermediates for the synthesis of ezetimibe, as well as the use of these intermediates for the preparation of ezetimibe.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2787NO – PubChem

 

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Electric Literature of 497-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Patent£¬once mentioned of 497-25-6

PROCESS FOR PRODUCING BETA-AMINOKETONE AND CATALYST THEREFOR

A conjugate addition reaction between an alpha,beta-unsaturated ketone compound and a carbamate compound is carried out to synthesize a beta-aminoketone, a salt or a hydrate salt of a transition metal of Groups 7 to 11 of the Periodic Table of Elements being present in the reaction system as the catalyst. The novel method and the catalyst are capable of synthesizing the beta-aminoketone by the Aza-Michael reaction with high yield and efficiency.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H145NO – PubChem

 

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Application of 497-25-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Article£¬once mentioned of 497-25-6

Role of aqueous methyldiethanolamine (MDEA) as solvent in natural gas sweetening unit and process contaminants with probable reaction pathway

Aqueous methyldiethanolamine (MDEA) is used as a solvent in natural gas sweetening unit, whose quality deteriorates while absorbing H2S/CO2 causing corrosion and foaming in the process. Total process contaminants of lean MDEA obtained from GASCO Company (Habshan, Abu Dhabi) were determined using different instruments. The major hydrocarbons found in inlet natural gas was analyzed using gas chromatography mass spectrometry (GC-MS). Heat stable salt (HSS) anions and metal ions were detected using ion chromatograph (IC) and inductively coupled plasma optical emission spectrometry (ICP-OES). Liquid chromatography mass spectrometry (LC-MS) and direct sample analysis time of flight (AxION 2TOF) analysis were carried out to determine and major organic degraded products present in lean MDEA solvent. The UV-VIS spectrophotometer also justified the presence of total organic acid anions. Acetate and propionate were found to be present in higher amounts of 2806 and 1614 ppm, respectively. Substantial amount of metal ions were also detected using ICP-OES with maximum level of heavy metal ions of lead and iron of 1.009 and 0.967 ppm, respectively. Large numbers of organic degraded products such as diethanolamine followed by methylethanolamine, N,N-bis(2-hydroxyethyl) glycine (bicine) etc. were identified using LC-MS and AxION 2TOF analyses; which are considered to be major organic thermally degraded products. Thermal degradation experiment was compared with H2S and in presence of both H2S/CO2 to obtain same compounds with varying concentration. On the basis of MDEA degradation as reported by previous researchers and from the analyzed lean MDEA samples, probable reaction pathways have been proposed.

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Copper-catalyzed intermolecular dehydrogenative amidation/amination of quinoline N-oxides with lactams/cyclamines

C-H, N-H dehydrogenative coupling of quinoline N-oxides with lactams/cyclamines has been achieved in the presence of the Cu(OAc)2 catalyst to give good to excellent yields. This study provides a new strategy for the construction of a 2-aminoquinoline skeleton via direct functionalization of aryl C-H bonds.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H736NO – PubChem

 

Simple exploration of (R)-4-Benzyl-2-oxazolidinone

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On the structure of the Phytophthora alpha1 mating hormone: synthesis and comparison of four candidate stereoisomers

Two two-compound mixtures of candidate structures for the Phytophthora alpha1 mating hormone have been synthesized. The mixtures were designed to have differing configurations at C3, but proved to be identical. This suggests that epimerization occurred at C3, and comparison with the data for the natural samples suggest that this is also a mixture of isomers.

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Awesome Chemistry Experiments For 102029-44-7

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1-HETEROCYCLYLAMINO-2-HYDROXY-3-AMINO-omega-ARYLALKANES

1-Heterocyclylamino-2-hydroxy-3-amino-?-arylalkanes of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.

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