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PROCESSES FOR PRODUCTION OF PHENOLIC 4-BIPHENYLYLAZETIDIN-2-ONES

The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives Formula (1)

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2788NO – PubChem

 

Extended knowledge of (R)-4-Benzyl-2-oxazolidinone

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Synthesis of two dipeptide isosteres containing di- and trisubstituted E-configured double bonds

The stereoselective syntheses of a Tyr-Tyr and a Pro-Pro E-alkene isostere are described. While the Tyr-Tyr isostere was synthesized following a convergent olefination strategy, the trisubstituted E-configured double bond of the Pro-Pro isostere was generated by an Ireland-Claisen rearrangement. The configuration of all key intermediates containing new stereocenters was determined by X-ray crystallography. Georg Thieme Verlag Stuttgart.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1723NO – PubChem

 

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Phosphazene/triisobutylaluminum-promoted anionic ring-opening polymerization of 1,2-epoxybutane initiated by secondary carbamates

Attempts to use a carbamate-phosphazene base as the initiating system for the polymerization of 1,2-epoxybutane was unsuccessful. As a matter of fact, carbamate deprotonation by phosphazene bases led to their fast decomposition generating alkoxide anions which initiate the polymerization rather than carbamate anions. Conversely, in the presence of triisobutylaluminum-a Lewis acid-the in situ generation of an anionic initiator X- obtained by the deprotonation of the tBuP4 phosphazene base was tested as a possible way to initiate the polymerization of 1,2-epoxybutane. Particular attention was given to the detection of eventual transfer or side-reactions according to the carbamate:triisobutylaluminum:phosphazene base ratio, to the solvent dielectric constant and to the number of PN- units in the phosphazene base. The reaction was performed with a stoichiometric ratio (1::1:1) of carbamate:triisobutylaluminum:tBuP2, which gave the best results. Under these conditions, the initiation of the polymerization by the carbamate anion was quantitative; no transfer reactions have been observed and the polymerization proceeded in a controlled manner to afford amide end-capped poly(butylene oxide) with a narrow molar mass distribution and expected molar masses.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H597NO – PubChem

 

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Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells

Two series of racemic goniothalamin analogues displaying nitrogen-containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF-7 (0.5 mum) and PC3 (0.3 mum) cells, about 26-fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco-2 cells (IC50=0.8 mum), about 10-fold more potent and 17-fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF-7, Caco-2, and PC3 cancer cell lines.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H808NO – PubChem

 

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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Product Details of 497-25-6In an article, once mentioned the new application about 497-25-6.

TERAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR

The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H194NO – PubChem

 

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Palladium-catalyzed hydroacyloxylation of ynamides

In the presence of substoichiometric Pd(OAc)2, carboxylic acids undergo highly regio- and stereoselective additions to ynamides to provide alpha-acyloxyenamides.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1010NO – PubChem

 

Awesome and Easy Science Experiments about (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

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Crystal structures – A manifesto for the superiority of the valine-derived 5,5-diphenyloxazolidinone as an auxiliary in enantioselective organic synthesis

The crystal structures of 32 derivatives of 4-isopropyl-5,5-diphenyl-1,3-oxazolidin-2-one (A and 1-31) are presented (Fig. 2 and Tables 1-3). In all but four structures, the Me2CH group is in a disposition that mimick a Me3C group (Figs. 3-5). The five-membered ring shows conformations from an envelope form with the Ph2C group out of the plane containing the other four atoms to the twist form with the twofold axis through the C=O group (Fig. 6, and Table 2). In the entire series, the Me2CH and the neighboring trans Ph group are approximately antiperiplanar (average torsion angle 155). The structural features are used to interpret the previously observed reactivity behavior of the diphenyl-oxazolidinone derivatives. The practical advantages of the title compound over classical Evans auxiliaries are outlined (Figs. 1 and 7, and Scheme 2): high crystallinity of all derivatives, steric protection of the C=O group in the ring, excellent stereoselectivities in reactions of its derivatives, and safe preparation and easy recovery of the auxiliary.

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Oxazolidine | C3H2630NO – PubChem

 

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Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles

(Chemical Equation Presented). An effective gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions and gives the polysubstituted pyrroles in good-to-excellent yields. Preliminary results indicate that a nongold carbenoid pathway is preferred for current pyrrole synthesis.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1217NO – PubChem

 

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Cyclic beta-amino acid derivatives as factor Xa inhibitors

The present application describes cyclic beta-amino acid derivatives or pharmaceutically acceptable salt forms thereof, wherein the central core is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

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Oxazolidine | C3H1578NO – PubChem

 

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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H93NO – PubChem