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Iridium-Catalyzed Highly Regioselective Azide-Ynamide Cycloaddition to Access 5-Amido Fully Substituted 1,2,3-Triazoles under Mild, Air, Aqueous, and Bioorthogonal Conditions

A highly regioselective method to access 5-amido fully substituted 1,2,3-triazoles by iridium-catalyzed azide-ynamide cycloaddition under mild, air, aqueous, and bioorthogonal conditions is reported. The excellent regioselectivities may derive from the strong coordination between the carbonyl oxygen of ynamide and the -acidic iridium. Since the iridium ion is insensitive to oxygen/water and exhibits low cytotoxicity, it could catalyze this reaction in both organic and biological environments efficiently. Preparation in gram-scale and application in carbohydrates highlight this method.

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Oxazolidine | C3H1016NO – PubChem

 

Archives for Chemistry Experiments of (R)-4-Benzyl-2-oxazolidinone

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Formal Total Synthesis of Actinoranone: Synthesis Approaches and Cytotoxic Studies

This article describes our efforts toward the total synthesis of actinoranone. Our synthesis strategies rely on a convergent route to connect the terpenoid and polyketide fragments, employing catalysis and powerful classical reactions for the assembly of these key fragments. A new transformation was disclosed during this work, a domino ring-opening and esterification. Initial cytotoxic studies for the selected synthesis intermediates are also presented.

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Oxazolidine | C3H1956NO – PubChem

 

Extended knowledge of 497-25-6

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Comparative life cycle assessment of potassium carbonate and monoethanolamine solvents for CO2 capture from post combustion flue gases

Carbon capture and storage (CCS) has the potential to enable significant reductions in carbon dioxide (CO2) emissions from stationary sources such as coal-fired power stations. The most advanced carbon capture technology is CO2 absorption using amine-based solvents, such as monoethanolamine (MEA). However, there is concern that the increased use of amine-based solvents will lead to other potential negative environmental impacts, such as increased human toxicity. The use of benign inorganic solvents, such as potassium carbonate, which do not degrade in the presence of oxygen or other impurities such as sulphurous or nitrous oxides offer significant advantages over amine-based solvents in terms of environmental impact.A comparative life cycle assessment (LCA) between the use of MEA and the CO2CRC’s potassium carbonate based UNO MK 3 technology for the capture of 1tonne of CO2 from a brown-coal fired power station has been completed. The results reveal that the UNO MK 3 process is significantly better than MEA on ecotoxicity and carcinogen emissions and substantially better on all other indicators. The benefits of the UNO MK 3 process compared with MEA are due to avoidance of emissions from MEA degradation along with the savings in energy use for CO2 removal.The significant environmental benefits of the UNO MK 3 process compared with MEA were not altered by an uncertainty analysis or sensitivity analysis of key inputs and assumptions.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H570NO – PubChem

 

Can You Really Do Chemisty Experiments About 102029-44-7

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Total synthesis of palmyrolide A and its 5,7-epi isomers

Stereoselective total synthesis of palmyrolide A, a 15-membered neuroactive macrolide, was described by adopting a synthetic strategy developed for the proposed structures, and its 5,7-epi isomers. The strategy was designed in such a way that the set of stereoisomers, which were needed for establishing the absolute configuration of palmyrolide A, could be obtained from one time operation. The diastereoselective hydrogenation of exo-methylene-gamma- butyrolactone to alpha-methyl-gamma-butyrolactone, Yamaguchi esterfication, and intramolecular dehydrative cyclization to form trans-enamide were the key steps involved in the synthesis.

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Selective alpha-arylation of alpha,beta-unsaturated imides mediated by a visible light photoredox catalyst

Visible light-mediated alpha-arylation of alpha,beta-unsaturated imides is achieved via aminium radicals generated from diarylalkylamines using a photoredox catalyst. On the basis of emission quenching experiments, a plausible pathway of the reaction is discussed.

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Extracurricular laboratory:new discovery of (S)-4-Phenyl-3-propionyloxazolidin-2-one

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A LCZ – 696 for the preparation of key intermediate (by machine translation)

The present invention provides a novel method for preparing anti-heart failure drug LCZ – 696 of the key intermediate (2 R, 4 S) – 5 – (biphenyl – 4 – yl) – 4 – [(tert-butoxy carbonyl) amino] – 2 – methyl valeric acid method, the reaction route is as follows: The present invention provides a preparation method of simple synthetic route, the operation is simple, low cost, easy to realize industrial production. (by machine translation)

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Chemoselective N-acylation of indoles and oxazolidinones with carbonylazoles

Unique reactivity: In the presence of more reactive amine and alcohol functional groups and of carboxylic acids, the chemoselective N-acylation of indoles (see scheme) and oxazolidinones is achieved by taking advantage of the unique reactivity of carbonylazole acylating agents with catalytic amounts of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Copyright

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Oxazolidine – Wikipedia,
Oxazolidine | C3H607NO – PubChem

 

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Cycloaddition of styrene oxide and CO2 mediated by pyrolysis of urea

This paper reports the effectiveness of carrying out the cycloaddition reaction of styrene oxide (SO) and CO2 without the use of any catalysts. A naturally abundant and cheap material, urea, was utilized in promoting the reaction by controlling the reaction conditions. The influence of reaction temperature, carbon dioxide (CO2) pressure, amount of urea, and the reaction time on the selectivity of styrene carbonate (SC) was investigated. The Royal Society of Chemistry 2013.

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Oxazolidine | C3H1052NO – PubChem

 

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SUBSTITUTED URACILS AND USE THEREOF

The present application relates to novel substituted uracil derivatives of formula (I), to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H96NO – PubChem

 

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Norbornyl dipeptide analogues: Mimics of both a transition state and a torsionally distorted ground state

The 1-amino-2-hydroxybicyclo[2.2.1]heptane-7 acid derivatives 1-3 have been synthesized, the pivotal step being the use of an acyl nitrene-insertion reaction to introduce nitrogen functionality into the corresponding hydroxy ester. The analogues each mimic a distorted peptide ground state as well as the transition state for peptide bond hydrolysis. To enhance the immune response and to provide further sequence specificity, the analogues 1-3 have been coupled to at least one D-amino acid residue to yield the derivatives 21, 26, and 27, respectively. Antibodies elicited against these derivatives may catalyze the hydrolysis of the corresponding peptides both by straining the substrate ground state and by stabilizing the transition state.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1011NO – PubChem