Heterocyclic Building Blocks-Oxazolidine

Synthetic Route of 102029-44-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a Patent£¬once mentioned of 102029-44-7

PURINE DERIVATIVES AS IMMUNOMODULATORS

The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1626NO – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 497-25-6, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 497-25-6, name is Oxazolidin-2-one. In an article£¬Which mentioned a new discovery about 497-25-6

INHIBITORS OF POLO-LIKE KINASE

The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson?s disease.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H182NO – PubChem

 

102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, belongs to oxazolidine compound, is a common compound. Quality Control of (R)-4-Benzyl-2-oxazolidinoneIn an article, once mentioned the new application about 102029-44-7.

Asymmetric synthesis of unusual amino acids: An efficient synthesis of optically pure isomers of beta-methylphenylalanine

Substitution of the diastereotopic beta-hydrogens of many alpha-amino acids provides an approach to the three dimensional topographic control of peptide structure. Asymmetric synthesis of the desired amino acids is needed to facilitate these studies. All four individual isomers of beta-methylphenylalanine, (2S,3S)-, (2R,3%)-, (2S,3R)- and (2R,3S)-beta-methylphenylalanine have been synthesized in high optical purity. The stereochemistry at the beta-center was set by the choice of starting material, either (+)- or (-)-3-phenylbutyric acid. These acids were attached to the appropriate D- or L-auxiliary (a 4-phenylmethyl-2-oxazolidinone) to give a 3′-phenylbutanoyl-4-phenylmethyl-2-oxazolidinone. Asymmetric bromination was accomplished via the chiral imide enolate bromination methodology of Evans and co-workers (J. Am. chem. Soc. 1990, 112, 4011-40). Evidence for asymmetric induction was obtained from the X-ray structure of one of the intermediate bromides. The bromide was converted to the diastereoisomeric azide by S(N)2 displacement using tetramethylguanidinium azide. After recovery of the chiral auxiliary by catalyzed hydrolysis, the chiral amino acid was obtained by catalytic hydrogenation over 10% Pd/C. All four isomers were obtained in enantiomeric purities of 95:5 to 99:1.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1796NO – PubChem

 

Reference of 3190-70-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.3190-70-3, Name is (S)-4-Isobutyloxazolidine-2,5-dione, molecular formula is C7H11NO3. In a article£¬once mentioned of 3190-70-3

Scale-up studies for the asymmetric Julia-Colonna epoxidation reaction

The asymmetric Julia-Colonna epoxidation reaction under triphasic/PTC conditions has been successfully scaled-up to a one-hundred gram substrate level providing the corresponding epoxy ketone with high optical purity (up to 97% ee) and in good yield (75-78%). The amount of polyamino acid catalyst could be reduced leading to a simplified reaction work-up. In order to minimise the overall reaction time baffled reactors with pitched-blade impellers have been employed.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1505NO – PubChem

 

Reference of 13590-42-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 13590-42-6, Name is (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate,introducing its new discovery.

Thermosensitive hydrogel from oligopeptide-containing amphiphilic block copolymer: Effect of peptide functional group on self-assembly and gelation behavior

We reveal that a slight change in the functional group of the oligopeptide block incorporated into the poloxamer led to drastically different hierarchical assembly behavior and rheological properties in aqueous media. An oligo(l-Ala-co-l-Phe-co-beta-benzyl l-Asp)-poloxamer-oligo(beta-benzyl-l- Asp-co-l-Phe-co-l-Ala) block copolymer (OAF-(OAsp(Bzyl))-PLX-(OAsp(Bzyl))-OAF, denoted as polymer 1), which possessed benzyl group on the aspartate moiety of the peptide block, was synthesized through ring-opening polymerization. The benzyl group on aspartate was then converted to carboxylic acid to yield oligo(l-Ala-co-l-Phe-co-l-Asp)-poloxamer-oligo(l-Asp-co-l-Phe-co-l-Ala) (OAF-(OAsp)-PLX-(OAsp)-OAF, denoted as polymer 2). Characterization of the peptide secondary structure in aqueous media by circular dichroism revealed that the oligopeptide block in polymer 1 exhibited mainly an alpha-helix conformation, whereas that in polymer 2 adopted predominantly a beta-sheet conformation at room temperature. The segmental dynamics of the PEG in polymer 1 remained essentially unperturbed upon heating from 10 to 50 C; by contrast, the PEG segmental motion in polymer 2 became more constrained above ca. 35 C, indicating an obvious change in the chemical environment of the block chains. Meanwhile, the storage modulus of the polymer 2 solution underwent an abrupt increase across this temperature, and the solution turned into a gel. Wet-cell TEM observation revealed that polymer 1 self-organized to form microgel particles of several hundred nanometers in size. The microgel particle was retained as the characteristic morphological entity such that the PEG chains did not experience a significant change of their chemical environment upon heating. The hydrogel formed by polymer 2 was found to contain networks of nanofibrils, suggesting that the hydrogen bonding between the carboxylic acid groups led to an extensive stacking of the beta sheets along the fibril axis at elevated temperature. The in vitro cytotoxicity of the polymer 2 aqueous solution was found to be low in human retinal pigment epithelial cells. The low cytotoxicity coupled with the sol-gel transition makes the corresponding hydrogel a good candidate for biomedical applications.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2408NO – PubChem

 

Reference of 152305-23-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.152305-23-2, Name is (S)-4-(4-Aminobenzyl)oxazolidin-2-one, molecular formula is C10H12N2O2. In a Article£¬once mentioned of 152305-23-2

Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties

1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1?22) were obtained by the reaction of (S)-4-(4-aminobenzyl)-2(1H)-1,3-oxazolidinone with 4-substituted benzoyl chlorides, 4-substituted benzene sulfonyl chlorides, and 4-substituted phenyl isothiocyanates. The structures of all synthesized compounds were clarified by FT-IR, NMR, and mass spectroscopic and elemental analysis techniques. The synthesized compounds were screened for their antimicrobial activity. Antimicrobial susceptibility and cellular physiology were evaluated using the microbroth dilution assay and the flow cytometry method. As a result, it was determined that compound 16 displayed better antimicrobial activity than chloramphenicol against Gram-positive bacteria, especially Staphylococcus aureus. In order to understand the mechanism of effect of the compounds on the cell membrane, fluorescence microscopy was used. Cell membrane damage of the Gram positive bacteria treated with compound 16 was observed as a result of intense staining with propidium iodide. In addition, genotoxicity, cytotoxicity, and absorption, distribution, metabolism, and excretion (ADME) parameters of compound 16 were examined and it was found as non-mutagenic and non-cytotoxic at the concentration at which it showed antimicrobial activity. According to the calculated ADME parameters and drug likeness scores, the compounds can be good drug candidates, especially compound 16.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2226NO – PubChem

 

Application of 497-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Patent£¬once mentioned of 497-25-6

RADIOLABELED COMPOUNDS AND THEIR USE AS RADIOTRACERS FOR QUANTITATIVE IMAGING OF PHOSPHODIESTERASE (PDE10A) IN MAMMALS

The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of PDE10A in mammals. The compound of the present invention is represented by the formula (I): wherein each symbols are as defined in the specification.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H232NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C3H5NO2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2

FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS

A series of substituted pyrazolo[1,5-alpha][1,3,5]triazine and pyrazolo[1,5-alpha]-pyrimidine derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, ontological, nociceptive or ophthalmic conditions. Formula (I)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C3H5NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 497-25-6, in my other articles.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H10NO – PubChem

 

Electric Literature of 497-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Patent£¬once mentioned of 497-25-6

OXAZOLIDINONE COMPOUNDS AND THEIR USES IN PHARMACEUTICALS

The invention relates to the field of blood coagulation, more specifically it relates to novel oxazolidinone compounds or a pharmaceutically acceptable salt thereof, and their uses in the manufacture of medicaments for treating thromboembolic disorders or inhibiting factor Xa.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H263NO – PubChem

 

Reference of 497-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Article£¬once mentioned of 497-25-6

Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

A direct catalytic method is described for the alpha,beta-desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic conditions. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups, showing reactivity complementary to that of prior desaturation methods. Lactams with various ring sizes and substituents at different positions all reacted smoothly. The synthetic utility of this method is demonstrated in a concise synthesis of Rolipram. In addition, linear amides also prove to be competent substrates, and the phthaloyl-protected product serves as a convenient precursor to access various conjugated carboxylic acid derivatives. Strong bases are avoided in this desaturation approach, and the key is to merge soft enolization with a Pd-catalyzed oxidation process.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H424NO – PubChem