Heterocyclic Building Blocks-Oxazolidine

On November 30, 2014, Valeev, Ruslan F.; Bikzhanov, Radmir F.; Miftakhov, Mansur S. published an article.Formula: C8H15NO2 The title of the article was Synthesis of the C6-C21 fragment of epothilone analogues. And the article contained the following:

(2S,4E,6Z,9S,10E)-9-[tert-Butyl(diphenyl)silyloxymethyl]-2,6,10-trimethyl-11-(2-methylthiazol-4-yl)undeca-4,6,10-trien-1-ol I, a key precursor for epothilone analogs, was prepared by multi-step synthesis using the Julia-Kocienski olefination at the key step. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Formula: C8H15NO2

The Article related to epothilone fragment preparation julia kocienski olefination, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 31, 2019, Zhu, Jidong; Cao, Hengyi; Sun, Lin published a patent.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Preparation of aminopyrimidine derivatives useful for the treatment of diseases associated with IDH mutation. And the patent contained the following:

The invention relates to aminopyrimidine derivatives of formula I, method for their preparation and their use for preventing and treating a disease associated with IDH mutation. Compounds of formula I, wherein A1 is a bond, CH2, CR2O, CR=CH, O, S, etc.; A2 to A10 are independently CR2, CHR, NR, O, S, etc.; B1 to B3 are independently CR and N; dotted bond is absent or double bond; R is H, halo, CN, (un)substituted C1-4alkyl, etc.; R4 and R6 are independently H, D, Me, Et, CF3, etc.; R1, R2, R3 and R5 are independently H, OH, halo, CN, etc.; D is (CH2)0-3, and their stereoisomers, racemates, pharmaceutically acceptable salts, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their isocitrate dehydrogenase 1 (IDH1) inhibitory activity. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to aminopyrimidine derivative preparation treatment cancer idh mutation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On November 5, 2010, Ohtani, Takashi; Tsukamoto, Shinya; Kanda, Hiroshi; Misawa, Kensuke; Urakawa, Yoshifumi; Fujimaki, Takahiro; Imoto, Masaya; Takahashi, Yoshikazu; Takahashi, Daisuke; Toshima, Kazunobu published an article.Application of 168297-86-7 The title of the article was Total Synthesis of Incednam, the Aglycon of Incednine. And the article contained the following:

The first total synthesis of incednam I (R = H), the aglycon of the macrolactam antibiotic incednine I (R = II), is described. Incednine has been reported to exhibit significant inhibitory activity against the antiapoptotic oncoproteins Bcl-2 and Bcl-xL. The synthesis of I (R = H) commenced with the preparation of the C1-C13 subunit III and the C14-C23 subunit IV. The construction of the novel 24-membered macrocycle was achieved by the application of a Stille coupling between III and IV, followed by macrolactamization. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application of 168297-86-7

The Article related to incednam incednine aglycon preparation stille coupling macrolactamization, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Application of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On July 24, 2014, Basarab, Gregory Steven; Gowravaram, Madhusudhan Reddy; Hauck, Sheila Irene; Zhou, Fei published a patent.Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the patent was Preparation of spiro[oxazino[4,3-a]isoxazolo[4,5-g]quinoline-pyrimidine]trione compounds and methods for treating bacterial infections. And the patent contained the following:

Compounds of formula I, pharmaceutically acceptable salts thereof, and uses of the compounds of formula I for treating bacterial infections are disclosed. Compounds of formula I wherein X is F and Cl; R1 is H, (un)substituted Ph, CN, tetrahydropyranyl, etc.; R2 is H, CN, pyridinyl and (un)substituted C1-3 alkyl; R3 is H and C1-3 alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by spirocyclization of (2R)-1-[[5-(1,3-Dioxolan-2-yl)-6,7-difluoro-1,2-benzoxazol-3-yl]amino]propan-2-ol with barbituric acid. The invention compounds were evaluated for their DNA gyrase inhibitory activity (data given). The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to spirooxazinoisoxazoloquinoline pyrimidinetrione preparation treatment bacterial infection, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cardillo, Giuliana; Orena, Mario; Sandri, Sergio; Tomasini, Claudia published an article in 1987, the title of the article was An efficient synthesis of (R)-(+)- and (S)-(-)-propranolol from resolved 5-(iodomethyl)oxazolidin-2-ones.Product Details of 97859-49-9 And the article contains the following content:

Oxazolidinones I and II were prepared by cyclization of (S)-PhCHMeNHCH2CH:CH2.HBr with iodine and Amberlyst A 26 in the CO3- form. I and II were converted in 8 steps to (S)-(-)- and (R)-(+)-propranolol, resp. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Product Details of 97859-49-9

The Article related to propranolol diastereomer, oxazolidinone iodomethyl preparation resolution, iodomethyloxazolidinone diastereomer preparation conversion propranolol, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Product Details of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 6, 2017, Sagawa, Naoya; Moriya, Hiroki; Hosokawa, Seijiro published an article.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Syn Selective Vinylogous Mukaiyama Aldol Reaction Using Z,E-Vinylketene N,O-Acetal with Acetals. And the article contained the following:

Stereoselective vinylogous Mukaiyama aldol reactions using the Z,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary, derived from (E)-3-pentenoic acid and L-valine, have been achieved. The reaction proceeded smoothly to give a syn adduct in high stereoselectivity. Since the products possess structures including δ-alkoxy-γ-methyl-α,β-unsaturated imide, this reaction would be applicable to synthesize polyketides in a short procedure. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to stereoselective vinylogous mukaiyama aldol vinylketene silyl acetal chiral auxiliary, alkoxy methyl unsaturated imide synthesis, polyketide synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 17, 2005, Kinoshita, Hironori; Takahashi, Natsuko; Iwamura, Tatsunori; Watanabe, Shin-ichi; Kataoka, Tadashi; Muraoka, Osamu; Tanabe, Genzoh published an article.Electric Literature of 168297-86-7 The title of the article was Synthesis of 3-sulfanylpropanols containing three consecutive stereocenters via tandem Michael-aldol reaction of enoyl thioamides with acetals as key reaction. And the article contained the following:

(2S,3S,1’R)-2-(α-Methoxybenzyl)-3-phenyl-3-sulfanylpropionamides were diastereoselectively prepared by the reaction of N-cinnamoyl-4S-isopropyl-5,5-dimethyloxazolidinethione with acetals in the presence of SnCl4. The absolute configuration of the three newly created contiguous stereocenters was determined by the x-ray anal. of the disulfide [orthorhombic, space group P212121, a 20.404(4), b 23.153(3), c 11.679(3) Å, V 5517(1) Å3, Z 4]. The amides were transformed into propanols by the reductive removal of the oxazolidinone moiety. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7

The Article related to sulfanylpropanol asym synthesis, enoyl thioamide acetal tandem stereoselective michael aldol, oxazolidinyloxopropyl disulfide preparation mol crystal structure, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Electric Literature of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 31, 1998, Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Polywka, Mario E. C.; Prasad, R. Shyam; Sanganee, Hitesh J. published an article.Recommanded Product: 168297-86-7 The title of the article was A practical procedure for the multigram synthesis of the SuperQuat chiral auxiliaries. And the article contained the following:

An efficient and simple synthesis of oxazolidin-2-one SuperQuat chiral auxiliaries is described which provides rapid access to multigram quantities of the auxiliaries. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to oxazolidinone superquat chiral auxiliary preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On March 12, 2014, Lv, Binhua; Li, Chengwei published a patent.Application of 97859-49-9 The title of the patent was Preparation of substituted oxazolidinone compounds as factor Xα inhibitors. And the patent contained the following:

The present invention relates to substituted oxazolidinone compounds I [wherein R1 = 5-(un)substituted 2-thienyl or 4-(un)substituted Ph; R2 = 3-oxo-4-morpholinyl, 2-oxo-1-piperidinyl, etc.; R3 and R4 = independently H, D, F, Cl, OH, CN, etc.; R5 and R6 = independently H, D, F, Cl, OH, etc.; with proviso], pharmaceutically acceptable salts, crystal forms, hydrates, or solvates thereof as factor Xα inhibitors for treating and/or preventing thromboembolic diseases. For example, II was prepared in a multi-step synthesis. The title compounds showed inhibitory activity with IC50 < 50 nM against human blood-coagulation factor Xα. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Application of 97859-49-9

The Article related to preparation oxazolidinone factor xa inhibitor treatment thromboembolic disease human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Application of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On February 27, 2014, Lv, Binhua; Li, Chengwei; Cao, Benwen published a patent.Electric Literature of 97859-49-9 The title of the patent was Preparation of substituted oxazolidinone compounds as factor Xα inhibitors. And the patent contained the following:

The present invention relates to substituted oxazolidinone compounds I [wherein R1 = 5-(un)substituted 2-thienyl or 4-(un)substituted Ph; R2 = 3-oxo-4-morpholinyl, 2-oxo-1-piperidinyl, etc.; R3 and R4 = independently H, D, F, Cl, OH, CN, etc.; R5 and R6 = independently H, D, F, Cl, OH, etc.; with proviso], pharmaceutically acceptable salts, crystal forms, hydrates, or solvates thereof as factor Xα inhibitors for treating and/or preventing thromboembolic diseases. For example, II was prepared in a multi-step synthesis, which showed inhibitory activity with IC50 of 0.002 nM against human blood-coagulation factor Xα. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Electric Literature of 97859-49-9

The Article related to preparation oxazolidinone factor xa inhibitor treatment thromboembolic disease human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Electric Literature of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem