Awesome Chemistry Experiments For Oxazolidin-2-one

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BISPHOSPHONATE COMPOUNDS

Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H83NO – PubChem

 

Top Picks: new discover of 102029-44-7

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CERTAIN MACROCYCLIC LACTAM DERIVATIVES

The invention relates to macrocyclic lactam derivatives of formula I STR1 wherein R is hydrogen or acyl; m is an integer from 4 to 9 inclusive; n is 1 or 2; p is zero, 1 or 2; X is–CONH–or–NHCO–; Y is S, O or CH 2 ; R 1 is–COOH; or R 1 is STR2 in which R 2 is hydrogen, lower alkyl, aryl-lower alkyl, amino-lower alkyl, hydroxy-lower alkyl, acyloxy-lower alkyl, lower alkoxy-lower alkyl, mercapto-lower alkyl, lower alkyl-(thio, sulfinyl or sulfonyl)-lower alkyl, or carboxy-lower alkyl, R 3 is hydrogen or lower alkyl, and q is zero or an integer from 1 to 5 inclusive; or R 1 is STR3 in which R 4 is hydrogen, lower alkyl, lower alkoxy, hydroxy or acyloxy, and r is 1 or 2; or R 1 is STR4 in which s is 1 or 2; or R 1 is STR5 in which R 5 and R 6 independently represent hydrogen, lower alkyl, C 5-or C 6-cycloalkyl, (hydroxy-, acyloxy or lower alkoxy-) lower alkyl, carbocyclic or heterocyclic monocyclic aryl, or (hydroxy-, acyloxy-or alkoxy-) lower alkyloxy-lower alkyl; or R 5 and R 6 together with the nitrogen to which they are attached represent pyrrolidino, piperidino, morpholino, piperazino or N-alkylpiperazino; and macrocyclic sulfur and oxygen containing lactam ring isomers in which a CH 2 group of (CH 2) m in formula I is replaced by O or S, and Y represents CH 2 ; and pharmaceutically acceptable prodrug esters of any above said compound with a free carboxyl group; and pharmaceutically acceptable salts of any said compounds with a free acid or basic salt forming group; pharmaceutical compositions comprising said compounds; methods for the preparation of said compounds and for the preparation of intermediates; and methods of treating disorders in mammals which are responsive to the inhibition of neutral endopeptidases by administration of said compounds to mammals in need of such treatment.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1640NO – PubChem

 

Archives for Chemistry Experiments of (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one

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PROCESS FOR SYNTHESIZING A CETP INHIBITOR

An efficient process is disclosed for producing a compound that is an inhibitor of CETP. The next to last step of the process is the coupling of an oxazolidinone derivative and a triphenyl compound to provide the methyl ester of a compound which is hydrolyzed to the active CETP inhibitor. (1)

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2772NO – PubChem

 

More research is needed about (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one

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Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

3,5-Diaryl-4,5-dihydropyrazoles were discovered to be potent KSP inhibitors with excellent in vivo potency. These enzyme inhibitors possess desirable physical properties that can be readily modified by incorporation of a weakly basic amine. Careful adjustment of amine basicity was essential for preserving cellular potency in a multidrug resistant cell line while maintaining good aqueous solubility.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2152NO – PubChem

 

Discovery of Oxazolidin-2-one

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Process for the production of optically active 4-aryl-2-pyrrolidinones

Stereoselective process for the production of (4R)- or (4S)-4-aryl-2-pyrrolidinones as well as intermediate products and the stereoselective process for the production of the optically active intermediate compounds.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H171NO – PubChem

 

Extracurricular laboratory:new discovery of 102029-44-7

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 102029-44-7, name is (R)-4-Benzyl-2-oxazolidinone, introducing its new discovery. Computed Properties of C10H11NO2

Enantioselective multicomponent synthesis of fused 6-5 bicyclic 2-butenolides by a cascade heterobicyclisation process

The successive coupling of an alkoxy(aryl/heteroaryl)carbene complex of chromium with either a ketone or an imide lithium enolate and then a 3-substituted (H, TMS, PhCH2, PhCH2CH2, Me) propargylic organomagnesium reagent has afforded novel hydroxy-substituted bicyclic [4.3.0]-gamma-alkylidene-2-butenolides with three modular points that has allowed the efficient introduction of molecular complexity, including a homopropargylic alcohol core. The selective formation of these five- or six-component heterobicyclisation products is the result of the regioselective integration of the Grignard reagent as a propargyl fragment followed by a cascade CO/alkyne/CO insertion, ketene trapping and elimination sequence. By using lithium enolates of chiral N-acetyl-2-oxazolidinones and the corresponding propargylic organocerium reagents, both enantiomers of these bicyclic heterocycles were efficiently prepared with very high enantiomeric purity. Architecturally, these fused bicyclic butenolides are characterised by a highly unsaturated and oxygenated core and they exhibit strong blue fluorescence in solution.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2036NO – PubChem

 

The Absolute Best Science Experiment for 497-25-6

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The direct reductive amination of electron-deficient amines with aldehydes: The unique reactivity of the Re2O7 catalyst

An unprecedented direct reductive amination of electron-deficient amines such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, Ar2PO-, etc. protected amines with aldehydes is achieved using the Re2O 7 catalyst and silanes as the hydride source. Excellent regioselective mono-alkylation and chemoselective reductive-amination were observed.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H468NO – PubChem

 

Brief introduction of 95715-86-9

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Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae

(Chemical Equation Presented) Two new serinolipid derivatives, shishididemniols A (1) and B (2), were isolated as antibacterial constituents of a tunicate of the family Didemnidae. The structure of 1 was elucidated by interpretation of spectral data and the application of the modified Mosher method to 1 and its suitable degradation products. Compound 2 was the chlorohydrin of 1. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2527NO – PubChem

 

Can You Really Do Chemisty Experiments About 16251-45-9

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Stereoselective synthesis of pamamycin-607

A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of beta-alkoxyvinyl ketone intermediates and a beta-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a beta-alkoxymethacrylate intermediate.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2168NO – PubChem

 

Some scientific research about (S)-tert-Butyl 4-(methoxy(methyl)carbamoyl)-2,2-dimethyloxazolidine-3-carboxylate

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POLYSACCHARIDE ANTIGEN-GLYCOLIPID CONJUGATE VACCINES

no abstract published

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2661NO – PubChem