Heterocyclic Building Blocks-Oxazolidine

497-25-6, In an article, published in an article,authors is Boto, Alicia, once mentioned the application of 497-25-6, Name is Oxazolidin-2-one,molecular formula is C3H5NO2, is a conventional compound. this article was the specific content is as follows.

Synthesis of unnatural amino acids from serine derivatives by beta-fragmentation of primary alkoxyl radicals

(Chemical Equation Presented) The fragmentation of primary alkoxyl radicals has been scarcely used in synthesis since other competing processes (such as oxidation or hydrogen abstraction) usually predominate. However, when serine derivatives were used as substrates, the scission took place in excellent yields. Tandem scission-allylation, -alkylation, or -arylation reactions were subsequently developed. This one-pot methodology was applied to the synthesis of unnatural amino acids, which are useful synthetic blocks or amino acid surrogates in peptidomimetics.

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102029-44-7, An article , which mentions 102029-44-7, molecular formula is C10H11NO2. The compound – (R)-4-Benzyl-2-oxazolidinone played an important role in people’s production and life.

Insights into long-range structural effects on the stereochemistry of aldol condensations: A practical total synthesis of desoxyepothilone F

A processable total synthesis of a potent antitumor agent, desoxyepothilone F (dEpoF, 21-hydroxy-12,13-desoxyepothilone B, 21-hydroxyepothilone D), has been accomplished. The route is highly convergent. The new technology has also been applied to a total synthesis of 12,13-desoxyepothilone (dEpoB). The crucial point of departure from previous syntheses of dEpoB and dEpoF involves presentation of the C1-C11 sector for Suzuki coupling with C3 in reduced form. Hitherto, the required S stereochemistry at C3 had been implemented via reduction of a keto function after Suzuki coupling. Whereas that chemistry worked quite well in a synthesis of dEpoB, it was not transferable to a high-yielding synthesis of dEpoF. The reduction of the keto group at C3 via a Noyori protocol after Suzuki coupling had proved to be very difficult. In our current approach, two consecutive aldol reactions are used to fashion the acyl sector. In the first aldol condensation, C6 becomes attached to C7. Following protection at C7, a two-carbon acetate equivalent is used to join C2 and C3 with very high asymmetric induction at C3. Only after this center has been implemented is the Suzuki reaction conducted. This major advance allowed us to synthesize dEpoF in a straightforward fashion. These findings found ready application in the total synthesis of dEpoB. Another part of the study involved analysis of the factors associated with aldol condensations joining C6 to C7. In the work described herein, the consequences of the status of C3 in promoting the C6-C7 aldol coupling are probed in detail. Dramatic stereochemical long-range effects uncovered during the study are described, and a working model to explain these effects has emerged.

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In an article, published in an article,authors is Birman, Vladimir B., once mentioned the application of 160695-26-1, Name is (R)-4-Phenyl-3-propionyloxazolidin-2-one,molecular formula is C12H13NO3, is a conventional compound. this article was the specific content is as follows. 160695-26-1

Kinetic resolution of 2-oxazolidinones via catalytic, enantioselective N-acylation

Kinetic resolution of racemic 2-oxazolidinones via catalytic, enantioselective N-acylation has been achieved for the first time and with outstanding selectivities. Copyright

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189028-93-1, An article , which mentions 189028-93-1, molecular formula is C20H18FNO4. The compound – (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione played an important role in people’s production and life.

Biocatalysis as useful tool in asymmetric synthesis: An assessment of recently granted patents(2014-2019)

The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This paper analyses the intellectual property activities of the last five years (2014-2019) with a specific focus on biocatalysis applied to asymmetric synthesis. Furthermore, to reflect the inventive and innovative steps, only patents that were granted during that period are considered. Patent searches using several keywords (e.g., enzyme names) have been conducted by using several patent engine servers (e.g., Espacenet, SciFinder, Google Patents), with focus on granted patents during the period 2014-2019. Around 200 granted patents have been identified, covering all enzyme types. The inventive pattern focuses on the protection of novel protein sequences, as well as on new substrates. In some other cases, combined processes, multi-step enzymatic reactions, as well as process conditions are the innovative basis. Both industries and academic groups are active in patenting. As a conclusion of this survey, we can assert that biocatalysis is increasingly recognized as a useful tool for asymmetric synthesis and being considered as an innovative option to build IP and protect synthetic routes.

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16251-45-9, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 16251-45-9

USE OF THIA OXO COMPOUNDS FOR LOWERING APO C3

Methods are disclosed to reduce apolipoprotein C-III (apoC-III) mRNA or protein in a subject in need thereof, comprising administering a pharmaceutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein R1 and R2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C1-C6 alkyl groups, with the proviso that R1 and R2 are not both hydrogen.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, 108149-65-1, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 108149-65-1, Name is (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate, molecular formula is C11H21NO4. In a Article, authors is Ramana£¬once mentioned of 108149-65-1

A formal synthesis of (+)-didemniserinolipid B employing a Pd-mediated 6-endo selective alkynediol cycloisomerization

Herein, we describe a concise assembly of central 6,8-dioxabicyclo[3,2,1]octane core of didemniserinolipid by employing a Pd-mediated alkynediol cycloisomerization and a formal total synthesis of didemniserinolipid B.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, 1676-86-4, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1676-86-4, Name is (S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate, molecular formula is C15H18N2O5. In a Article, authors is Ren, Qi-Zhi£¬once mentioned of 1676-86-4

Phase-transfer of porphyrins by polypeptide-containing hyperbranched polymers and a novel iron(iii) porphyrin biomimetic catalyst

Water-soluble porphyrins can be phase transferred by the hyperbranched multiarm copolymer PEI-PZLys; good catalytic activities and recyclabilities were observed for oxidation catalyzed by the encapsulated porphyrins. The Royal Society of Chemistry 2009.

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 16251-45-9, molcular formula is C10H11NO2, introducing its new discovery. 16251-45-9

SUBSTITUTED PYRAZOLO-PYRIDINAMINES

The present invention relates to substituted pyrazolopyridine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

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147959-19-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 147959-19-1, Name is (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate,introducing its new discovery.

Synthesis of sphingosine analogues: Stereoselective synthesis of 3- deoxysphingosine and cis-isomers

Both enantiomers of 3-deoxysphingosine as well as their cis-isomers were synthesized stereoselectively from L- and D-serine.

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Because a catalyst decreases the height of the energy barrier, 173604-33-6, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.173604-33-6, Name is (R)-4-Benzhydryloxazolidin-2-one, molecular formula is C16H15NO2. In a article£¬once mentioned of 173604-33-6

First stereoselective inverse demand [4 + 2] cycloaddition reactions of novel chiral allenamides with heterodienes. Preparation of highly functionalized 2-arylpyranyl heterocycles

matrix presented The first stereoselective inverse demand [4 + 2] cycloaddition reactions of chiral allenamides with heterodienes are described here. These reactions lead to stereoselective synthesis of highly functionalized pyranyl heterocycles. A mechanistic model is also proposed here based on the stereochemical assignment and comparisons of stereoselectivities obtained from various chiral allenamides. ? 1999 NSF-REU Summer Undergraduate Research Participant from Florida A & M University.

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