Heterocyclic Building Blocks-Oxazolidine

108149-65-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 108149-65-1, Name is (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate, molecular formula is C11H21NO4. In a Article, authors is Nagaoka, Hikaru£¬once mentioned of 108149-65-1

Docking model of the nicotinic acetylcholine receptor and nitromethylene neonicotinoid derivatives with a longer chiral substituent and their biological activities

In the present study, nitromethylene neonicotinoid derivatives possessing substituents that contain a sulfur atom, oxygen atom or aromatic ring at position 5 on the imidazolidine ring were synthesized to evaluate their affinity for the nicotinic acetylcholine receptor (nAChR) and their insecticidal activity against adult female houseflies. Comparing the receptor affinity of the alkylated derivative with the receptor affinity of compounds possessing either ether or thioether groups revealed that conversion of the carbon atom to a sulfur atom did not influence the receptor affinity, whereas conversion to an oxygen atom was disadvantageous for the receptor affinity. The receptor affinity of compounds possessing a benzyl or phenyl group was lower than that of the unsubstituted compound. Analysis of the three-dimensional quantitative structure-activity relationship using comparative molecular field analysis demonstrated that steric hindrance of the receptor should exist around the C3 of an n-butyl group attached at position 5 on the imidazolidine ring. A docking study of the nAChR-ligand model suggested that the ligand-binding region expands as the length of the substituent increases by brushing against the amino acids that form the binding region. The insecticidal activity of the compounds was positively correlated with the receptor affinity by considering log P and the number of heteroatoms, including sulfur and oxygen atoms, in the substituents, suggesting that the insecticidal activity is influenced by the receptor affinity, hydrophobicity, and metabolic stability of the compounds.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 108149-65-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108149-65-1, in my other articles.

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Oxazolidine | C3H2310NO – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 497-25-6, Name is Oxazolidin-2-one. In a document type is Article, introducing its new discovery., 497-25-6

Multicomponent Strategy for the Synthesis of Prostaglandin E2 Methyl Ester under Anion Relay Chelation Control

(Chemical Equation Presented). Starting with four components, the enantioselective synthesis of prostaglandin E2 methyl ester has been achieved through a highly stereoselective heteroatom-directed conjugate addition reaction and cyclopentanone ring cyclization as the key steps. This asymmetric strategy includes (i) an asymmetric Reformatsky reaction; (ii) conjugate addition of a chiral vinyllithium reagent; (iii) cyclization to form a sulfonylated cyclopentanone in one-pot; followed by (iv) allylation of the side chain. Four carbon-carbon bond-forming processes and three stereogenic centers were established, with the steps from (ii) to (iii) being achieved in a one-pot process.

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108149-65-1, An article , which mentions 108149-65-1, molecular formula is C11H21NO4. The compound – (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate played an important role in people’s production and life.

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics

Several acyclic hydroxy-methylthio-amines with 3-5 carbon atoms were prepared and coupled via a methylene link to 9-deazaadenine. The products were tested for inhibition against human MTAP and Escherichia coli and Neisseria meningitidis MTANs and gave Ki values as low as 0.23 nM. These results were compared to those obtained with 1st and 2nd generation inhibitors (1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-d-ribitol (MT-Immucillin-A, 3) and (3R,4S)-1-[9-deazaadenin-9-yl)methyl]3-hydroxy-4- methylthiomethylpyrrolidine (MT-DADMe-Immucillin-A, 4). The best inhibitors were found to exhibit binding affinities of approximately 2- to 4-fold those of 3 but were significantly weaker than 4. Cleavage of the 2,3 carbon-carbon bond in MT-Immucillin-A (3) gave an acyclic product (79) with a 21,500 fold loss of activity against E. coli MTAN. In another case, N-methylation of a side chain secondary amine resulted in a 250-fold loss of activity against the same enzyme [(¡À)-65 vs (¡À)-68]. The inhibition results were also contrasted with those acyclic derivatives previously prepared as inhibitors for a related enzyme, purine nucleoside phosphorylase (PNP), where some inhibitors in the latter case were found to be more potent than their cyclic counterparts.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2294NO – PubChem

 

497-25-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Article, authors is Pereira, Elisabeth Rodrigues£¬once mentioned of 497-25-6

Syntheses and antimicrobial activities of five-membered ring heterocycles coupled to indole moieties

Indole-substituted oxazolidinones, oxazolones, pyrrolidinone, imidazolidinone and imidazolones were synthesized. Their inhibitory potencies towards protein kinase C and protein kinase A were determined and their in vitro activities against Streptomyces chartreusis, Streptomyces griseus, Bacillus cereus, Candida albicans and Escherichia coli were examined. The inhibition of Streptomyces sporulation observed for some of them could not be linked to in vitro protein kinase C inhibition. All proved inactive against C. albicans but three of them exhibited a marked activity towards E. coli. This effect extends to other Gram-negative bacteria.

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Oxazolidine | C3H892NO – PubChem

 

102029-44-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a Article, authors is Sharma, Rishi£¬once mentioned of 102029-44-7

Controlled-deactivation cannabinergic ligands

We report an approach for obtaining novel cannabinoid analogues with controllable deactivation and improved druggability. Our design involves the incorporation of a metabolically labile ester group at the 2?-position on a series of (-)-Delta8-THC analogues. We have sought to introduce benzylic substituents alpha to the ester group which affect the half-lives of deactivation through enzymatic activity while enhancing the affinities and efficacies of individual ligands for the CB1 and CB2 receptors. The 1?-(S)-methyl, 1?-gem-dimethyl, and 1?-cyclobutyl analogues exhibit remarkably high affinities for both CB receptors. The novel ligands are susceptible to enzymatic hydrolysis by plasma esterases in a controllable manner, while their metabolites are inactive at the CB receptors. In further in vitro and in vivo experiments key analogues were shown to be potent CB1 receptor agonists and to exhibit CB1-mediated hypothermic and analgesic effects.

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7517-99-9, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 7517-99-9

HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION THEREOF

The present disclosure relates to compounds of Formula I, or their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.

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497-25-6, In an article, published in an article,authors is Chahen, Ludovic, once mentioned the application of 497-25-6, Name is Oxazolidin-2-one,molecular formula is C3H5NO2, is a conventional compound. this article was the specific content is as follows.

Comprehensive monitoring of MEA degradation in a post-combustion CO2 capture pilot plant with identification of novel degradation products in gaseous effluents

A pilot plant campaign was performed to study MEA degradation in CO2 capture conditions and anticipate potential degradation products emissions to the atmosphere in industrial case. Aqueous 30% wt MEA was cycled between absorption and regeneration steps during 1700 h in the presence of a synthetic flue gas containing 81% of N2, 14% of CO2, 5% of O2, 97 ppm of NO, 9 ppm of SO2 and 5 ppm of NO2. Specific methods (sampling, sample conditioning and analysis) were developed to improve degradation products identification and to provide a quantification of targeted compounds in liquid phase and above all in absorber and stripper gas effluents. Especially, trace elements were detected in liquid phase thanks to Head Space-Solid Phase MicroExtraction (HS-SPME) and liquid-liquid extraction with ChemElut cartridges and in gas phase thanks to adsorbent tubes of different type: Sep-Pak for aldehydes and ketones, Orbo 60 for N-nitrosodimethylamine, Tenax and active charcoal for non-specific adsorption. 32 degradation products were identified in liquid phase and 38 in gas phase, 17 of which for the first time, especially derivatives of pyridine and oxazolidine, 1H-pyrrole and a new nitrosamine, the N-nitroso-2-methyl-oxazolidine.

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444335-16-4, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 444335-16-4

9,9,10,10-TETRAFLUORO-9,10-DIHYDROPHENANTHRENE HEPATITIS C VIRUS INHIBITOR AND APPLICATION THEREOF

The present invention belongs to the field of chemical pharmaceuticals, and specifically relates to compounds represented by formula I having a 9,9,10,10-tetrafluoro-9,10-dihydrophenanthrene structure and being able to inhibit hepatitis C virus activity, or a pharmaceutically acceptable salt, isomer, solvate, crystal or prodrug of said compounds, a pharmaceutical composition containing said compounds, and an application of said compounds or composition in the preparation of a drug. The compounds of the present invention have a good HCV inhibitory effect.

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Oxazolidine | C3H2683NO – PubChem

 

497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. 497-25-6In an article, authors is Akkarachalanont, Phattara, once mentioned the new application about 497-25-6.

New reactive extraction based reclaiming technique for amines used in carbon dioxide capture process from industrial flue gases

A new reclaiming technique based on reactive extraction for removal of heat stable salts (HSS) from monoethanolamine (MEA) used in carbon dioxide (CO2) capture process has been developed. The extraction process was based on the use of tri-n-octylamine (TOA), Aliquat 336, OH- modified Aliquat 336, a two-step extraction (modified Aliquat followed by TOA), and mixed extractant (modified Aliquat and TOA) in 1-octanol diluent. The best parameters were 69% OH- modified Aliquat, two-step extraction, and mixed extractant (modified Aliquat and TOA) and under optimum extraction conditions were able to improve the extraction efficiency of the original Aliquat and TOA to over 90%. The two-step extraction and mixed extractant were also capable of managing Cl- contamination in MEA solution. Extraction was found to be independent of temperature whereas efficiency reduced with increase of CO2 loading. Therefore, it is recommended to apply this extraction technique to the lean MEA stream after the rich/lean heat exchanger either with or without cooling. Regeneration of used extractant (OH Aliquat) was implemented and optimized with the use of 4 kmol/m3 NaOH. In addition to HSS removal, the new extraction technique was also able to remove major nonionic degradation products also by up to 90%.

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Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2, 497-25-6, In a Article, authors is Niemi, Teemu£¬once mentioned of 497-25-6

Direct assembly of 2-oxazolidinones by chemical fixation of carbon dioxide

The reaction of beta- and gamma-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations. The reaction of beta- and gamma-haloamines with carbon dioxide to give pharmaceutically relevant cyclic urethanes was found to proceed efficiently in the presence of a base and in the absence of catalyst (see figure). After optimization of reaction conditions, the system was expanded to a variety of haloamines, even at a multigram scale. The reaction was further studied in silico by DFT calculations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.497-25-6. In my other articles, you can also check out more blogs about 497-25-6

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