Heterocyclic Building Blocks-Oxazolidine

13590-42-6, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At -25 & lt; 0 & gt; C,2.5 g (10.0 mmol) of Intermediate II was dissolved in 30 mL of dry tetrahydrofuran,1.3 eq of methyl chloroformate was added dropwise,1.5 eq of N-methylmorpholine (NMM) was dissolved in 5 mL of tetrahydrofuran and added dropwise to the reaction system over 15 minutes,Stirred at -25 & lt; 0 & gt; C for 1 h,Then warmed to room temperature and stirred overnight.The reaction system was allowed to cool to -25 C,Was acidified with a 4.0 M solution of HCl dioxane,Until the pH of the solution is close to 3.The reaction solution was allowed to warm to room temperature.Under nitrogen protection,The reaction solution was passed through a dry 521 type diatomaceous earth (3.0 g) and treated with tetrahydrofuran as a mobile phase (2 x 5.0 mL)The N-methylmorpholine (NMM) hydrochloride precipitate was removed by filtration.After the filtrate was concentrated,Using TBME / THF / hexanes as solvent,The crystals were recrystallized overnight at -20 C.The solid was collected and stored in a vacuum drier (88% yield).

13590-42-6, As the paragraph descriping shows that 13590-42-6 is playing an increasingly important role.

Reference£º
Patent; Guizhou University; Liu Xiongli; Tian Minyi; Yao Zhen; Liu Xiongwei; Zhang Min; Zhou Ying; Feng Tingting; Yu Zhangbiao; (6 pag.)CN107129501; (2017); A;,
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147959-19-1, (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: (5)-tert-butyl 4-((S)-2-hydroxypropyl)-2,2-dimethyloxazolidine-3 -carboxylateTo a solution of (5)-tert-butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate (2.15 g,8.84 mmol) in dry THF (20 mL) at 18C was added 3M methylmagnesium bromide (4.42 ml,13.26 mmol) in a schlenk tube. The mixture was stirred for 16 h. TLC showed the reaction wascomplete. The mixture was diluted with sat. NH4C1 solution (40 mL) and extracted with EtOAc (70 mL x 3). The combined organic layers were washed with water (40 mL) and brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified with combi flash (flash colunm silica-CS (40 g) PE/EtOAc= 100:1 5: 1) to give the title compound. MS (ESI) m/z 260.1 (M+H).

147959-19-1, The synthetic route of 147959-19-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIM, Yeon-Hee; GUO, Zhuyan; ALI, Amjad; EDMONDSON, Scott, D.; LIU, Weiguo; GALLO-ETIENNE, Gioconda, V.; WU, Heping; GAO, Ying-Duo; STAMFORD, Andrew, M.; YU, Younong; KEVIN, Nancy, J.; ANAND, Rajan; SHA, Deyou; NEELAMKAVIL, Santhosh, F.; HUSSAIN, Zahid; KUMAR, Puneet; MONINGKA, Remond; DUFFY, Joseph, L.; XU, Jiayi; JIANG, Yu; SONE, Hiroki; CHAKRABARTI, Anjan; (183 pag.)WO2015/164308; (2015); A1;,
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2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 29 (E)-4-[2-(5-Methyl-2-phenyl-4-oxazolyl)vinyl]cinnamaldehyde and 2,4oxazolidinedione were reacted in the same manner as in Reference Example 28 to yield (E,E)-5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)vinyl]cinnamylidene]2,4-oxazolidinedione, which was then recrystallized from chloroform-methanol to yield yellow needles having a melting point of 274-275 C., 2346-26-1

2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5614544; (1997); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

General procedure: Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 39 (0.100g, 0.433mmol), appropriate substituted phenol (0.649mmol) and PPh3 (0.182g, 0.693mmol) in anhydrous toluene (5mL) was added DIAD (0.14mL, 0.693mmol) at 80C. After 3h, EtOAc (40mL) was added to the resulting solution. The organic layer was washed with 0.5M aqueous NaOH (40mL) and water (2¡Á40mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash silica gel column chromatography eluting with Hexanes/EtOAc (9:1) or (95:5).

108149-63-9, 108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Andrade, Saulo F.; Oliveira, Barbara G.; Pereira, Larissa C.; Ramos, Jonas P.; Joaquim, Angelica R.; Steppe, Martin; Souza-Fagundes, Elaine M.; Alves, Ricardo J.; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 13 – 25;,
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695-53-4, 5,5-Dimethyloxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,695-53-4

(a) A mixture of 1 (0.10 g, 0.77 mmol), 2 (0.10 g, 0.77 mmol), anhydrous NiCl2 (0.1 g, 0.8 mmol), urea (0.09 g, 1.55 mmol), and a catalytic amount of MOA was stirred in quinoline (5 mL) at 250 C under argon for 30 min. After cooling to room temperature, the reaction mixture was diluted with 50% ethanol (50 mL). The resulting precipitate was filtered, and washed successively with hot water and hot 50% ethanol until the washings were colorless. The crude residue was transferred to a Soxhlet apparatus, and was extracted with toluene. The toluene solution was concentrated to approximately 5 mL under a reduced pressure, which was purified by silica gel column chromatography using toluene as eluent. The blue fraction was collected to give 6 mg of 3 (4.2%) after evaporation of the solvent. MASS (MALDI) (m/z): 553 (M++1). Anal Calcd for C29H18N8O1Ni: C, 62.96; H, 3.28; N, 20.26. Found: C, 62.69; H, 3.51; N, 19.95.

As the paragraph descriping shows that 695-53-4 is playing an increasingly important role.

Reference£º
Article; Dudkin, Semyon V.; Makarova, Elena A.; Fukuda, Takamitsu; Kobayashi, Nagao; Lukyanets, Evgeny A.; Tetrahedron Letters; vol. 52; 23; (2011); p. 2994 – 2996;,
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875444-08-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.875444-08-9,(4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

Oxazolidinone 9 (81 mg, 0.257 mmol) was placed in a 5 mL vial, which was purged with nitrogen, and then dissolved in DMF (900 mu, 849.60 mg). The solution was cooled to -20C. NaHMDS (129 mu, 0.257 mmol) was added slowly to maintain the reaction temperature at less than -15C. The mixture was aged for 5 minutes, and then the pyridyl chloride 8 (90 mg, 0.257 mmol) was added as a solution in DMF (900 mu). The reaction was warmed to room temperature slowly. The reaction was complete after 2h at ambient temperature. The reaction was quenched with MTBE and water. The layers were separated. The organic layer was washed with water, then dried with MgSC^, and the solvent was removed by evaporation. Compound 10 (150 mg) was obtained, which could be used directly in the next step.

As the paragraph descriping shows that 875444-08-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; THOMPSON, Christopher, F.; SWEIS, Ramzi, F.; WO2011/28395; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.

80-65-9, EXAMPLE I 3-[(4-Chromanylidene)amino]-2-oxazolidinone A 62-g (0.61 mole) portion of 3-amino-2-oxazolidinone was charged in a 500-ml, 3-necked flask equipped with a thermometer, stirrer and reflux condenser, and treated successively with 92 ml of H2 O, 8 ml of 10% HCl and 42 g (0.28 mole) of 4-chromanone in 200 ml ethanol. The reaction mixture was refluxed for 36 hr, stripped in vacuo to one-half volume and cooled in the refrigerator overnight. The slurry was filtered and the white crystalline solid washed with 50 ml of isopropanol then 200 ml of ether and dried. M.p. 105-108. Yield: 44 g (68%). The filtrate was extracted with 250 ml of CHCl3, and the CHCl3 extract dried over MgSO4, filtered, and stripped in vacuo.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Patent; Morton-Norwich Products, Inc.; US4093627; (1978); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

(3) 500 mg (1.2 mmol) of Compound IV was dissolved in 10 ml of methanol,Add 247 mg (2.4 mmol) of the furazolidone metabolite AOZ,After reacting at 60 C for 1.5 h or more, the reaction is completed and cooled to room temperature.Filtration, the furazolidone metabolite hapten V-AOZ 475mg,The mass spectrum of V-AOZ is shown in Figure 2.

The synthetic route of 80-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dayuan Oasis Food Security Technology Co., Ltd.; Guangdong Dayuan Food Medicine Security Co., Ltd.; Guangzhou Dayuan Food Security Co., Ltd.; Li Bin; Shi Song; Xie Junping; Jiang Linfeng; Ling Jialiang; Shi Linhua; Ren Jiyu; (19 pag.)CN108530373; (2018); A;,
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695-53-4, 5,5-Dimethyloxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,695-53-4

Example 124(3R*,4R*)-N-[3,5-bis(trifluoromethyl)benzyl]-1-[2-(5,5-dimethyl-2,4-dioxo-1,3-oxazolidin-3-yl)ethyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride(step 1)To a solution of 5,5-dimethyl-1,3-oxazolidine-2,4-dione (500 mg) in DMF (10 mL) was added NaH (186 mg) at room temperature, and the mixture was stirred for 5 min. 1-Bromo-2-chloroethane (430 muL) was further added, and the mixture was stirred at room temperature for 4 days. The reaction mixture was concentrated under reduced pressure, and ethyl acetate was added to the residue. The organic layer was washed with aqueous citric acid solution and water and dried, and the solvent was evaporated under reduced pressure to give crude 3-(2-chloroethyl)-5,5-dimethyl-1,3-oxazolidine-2,4-dione as a colorless oil.

The synthetic route of 695-53-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shirai, Junya; Morimoto, Shinji; Sugiyama, Hideyuki; Sakauchi, Nobuki; Yoshikawa, Takeshi; US2008/275085; (2008); A1;,
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