Heterocyclic Building Blocks-Oxazolidine

95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

95530-58-8, General procedure: Pivaloyl chloride (0.684 mL, 5.69 mmol) was added, over 30 min, into a mixture of compound 6 (2.117 g, 5.42 mmol) and triethylamine (0.907 mL, 6.51 mmol) in dry tetrahydrofuran (50 mL) at -78 C. Sequentially, the resulting solution was stirred at 0 C for 30 min and recooled to -78 C. A -78 C solution of lithium (R)-4-isopropyl-2-oxooxazolidin-3-ide (prepared from (R)-4-isopropyloxazolidin-2-one (0.770 g, 5.96 mmol) and nBuLi (3.73 mL 1.6 M/hexane, 5.96 mmol) in THF at -78 C) was transferred through a cannula to the mixture above. Then the resulting mixture was warmed to room temperature. After another 30 min stirring, the reaction was quenched with a saturated NH4Cl aqueous (100 mL), and then extracted with ethyl acetate (100 mL). Organic layer was washed with brine and dried over anhydrous Na2SO4. The organic solution was concentrated and the residue was over silica gel column eluting with petroleum ether/ethyl acetate (2:1) to give compound (R)-7 (2.268 g, 83.4%) as a yellow oil; 1H NMR (300 MHz, CDCl3) delta 7.99-7.96 (m, 2H, ArH), 7.50 (s, 1H, ArH), 7.43-7.40 (m, 3H, ArH), 7.36 (d, 1H, ArH, J = 8.7 Hz), 7.16 (d, 1H, ArH, J = 8.7 Hz), 4.43-4.38 (m, 1H, CH), 4.27-4.16 (m, 2H, CH2), 3.36-3.17 (m, 2H, CH2), 3.07 (t, 2H, CH2, J = 6.8 Hz), 2.96 (t, 2H, CH2, J = 7.4 Hz), 2.63 (t, 2H, CH2, J = 7.2 Hz), 2.37-2.22 (m, 2H, CH2), 2.30 (s, 3H, CH3), 0.89 (d, 3H, CH3, J = 7.5 Hz), 0.82 (d, 3H, CH3, J = 6.9 Hz); HRMS-ESI+: C29H31N3O5 calcd [M + H]+ 502.2342, found 502.2359.

95530-58-8 (R)-4-Isopropyloxazolidin-2-one 641505, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Wei; Liu, Wenlu; Jiang, Xizhen; Jiang, Faqin; Zhuang, Hao; Fu, Lei; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 3639 – 3650;,
Oxazolidine – Wikipedia
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497-25-6, Oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,497-25-6

General procedure: In a 250 cm3 two-neck round-bottom flask equipped with astir-bar, CuCl2(0.2 equiv.), nitrogen nucleophile (5 equiv.),and Na2CO3(2 equiv.) were combined. The reaction flask was purged with oxygen gas. A solution of pyridine(2 equiv.) in dry toluene (0.06 M) was added to the reactionflask and stirred at 70 C. After 0.5 h, a solution ofthe respective alkyne (1.0 equiv.) in dry toluene (0.033 M)was added to the flask over 4 h using a syringe pump. Afteraddition of alkyne/toluene solution, the reaction mixture wasallowed to stir at 70 C overnight. After cooling to r.t., thecrude mixture was concentrated under reduced pressure. Theresidue was purified by column chromatography on silicagel.

As the paragraph descriping shows that 497-25-6 is playing an increasingly important role.

Reference£º
Article; Brutiu, Bogdan R.; Bubeneck, Wilhelm Andrei; Cvetkovic, Olivera; Li, Jing; Maulide, Nuno; Monatshefte fur Chemie; vol. 150; 1; (2019); p. 3 – 10;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-83-1,5,5-Dimethyloxazolidin-2-one,as a common compound, the synthetic route is as follows.,1121-83-1

To a solution of 6-(6-fluoro-4-iodo-2-pyridyl)-5-methyl-2-pyrimidin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine (the product of step 1 in Example 96, 100 mg, 223 muiotaetaomicron) in dioxane (3mL) was added 5,5-dimethyloxazolidin-2-one (51.4 mg, 446 muiotaetaomicron), cesium carbonate (145 mg, 446 muiotaetaomicron), Xantphos (25.8 mg, 44.6 muiotaetaomicron) and Pd(OAc)2(5.01 mg, 22.3 muiotaetaomicron). The reaction mixture was heated at 100 C with stirring for 20 hrs under Ar. After being cooled to rt, the resulting mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by prep-HPLC to give 3-[2-Fluoro-6-(5-methyl-2-pyrimidin-2-yl-7,8-dihydro-5H-pyrido [4,3-d]pyrimidin-6-yl)-4-pyridyl]-5,5-dimethyl-oxazolidin-2-one (8 mg) as a light yellow solid. 1H NMR (400MHz, DMSO-<) delta ppm: 8.99 (d, 2H), 8.95 (s, 1H), 7.64 (t, 1H), 6.72 (s, 6.70 (s, 1H), 5.71-5.66 (m, 1H), 4.51 - 4.40 (m, 1H), 3.93 (s, 2H), 3.56 - 3.44 (m, 1H), 3.12 - 2.97 (m, 2H), 1.53 (d, 3H), 1.49 (d, 6H). MS obsd (ESI) [(M+H)+]: 436. As the paragraph descriping shows that 1121-83-1 is playing an increasingly important role. Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; HAN, Xingchun; JIANG, Min; WANG, Jianhua; WANG, Yongguang; YANG, Song; (211 pag.)WO2018/1952; (2018); A1;,
Oxazolidine – Wikipedia
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80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

80-65-9, General procedure: Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%.

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.

80-65-9, General procedure: Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%.

The synthetic route of 80-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.

Isobutyl chloroformate (2.51 g; 2.40 mL; 18.36 mmol) and triethylamine (2.25 g; 3.10 mL; 22.24 mmol) were added to a cold (0 C) solution of aminoacetal 2c from the previous step (?3.35 g; 14.27 mmol) in dichloromethane (11 mL) under an argon atmosphere. The reaction mixture was vigorously stirred for 30 min at 0 C, then ethanethiol (2.01 g; 2.40 mL; 32.41 mmol) and triethylamine (2.25 g; 3.10 mL; 22.24 mmol) were added. The resulting solution was stirred for 30 min at 0 C and 45 min at rt. The reaction mixture was diluted with dichloromethane (25 mL), washed with water (40 mL) and brine (30 mL), dried over anhydrous MgSO4, concentrated under reduced pressure and purified by distillation under reduced pressure (bp 110 C/0.3 mmHg) to give 2.19 g (53% over three steps) of thioester 5, as white crystals.

139009-66-8, The synthetic route of 139009-66-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Trajkovic, Milos; Ferjancic, Zorana; Saicic, Radomir N.; Tetrahedron Asymmetry; vol. 23; 8; (2012); p. 602 – 604;,
Oxazolidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

A solution of 3 g (11.90 mmol) of 1-(4-bromobutyl)-1H-indole, prepared in stage 2.1., of 2.41 g (23.80 mmol) of 1,3-oxazolidin-2,4-dione (J. Med. Chem., 1991, 34, 1538-1544) and of 2.74 g (23.80 mmol) of 1,1,3,3-tetramethylguanidine in 30 ml of tetrahydrofuran is brought to reflux for 14 hours under an inert atmosphere. The mixture is concentrated under reduced pressure. The residue is taken up in ethyl acetate and water, the aqueous phase is separated and extracted twice with ethyl acetate, and the combined organic phases are washed with a saturated aqueous sodium chloride solution and dried over sodium sulphate. After evaporation of the solvent, the residue obtained is purified by chromatography on silica gel, elution being carried out with a 10/90 and then 20/80 mixture of ethyl acetate and of cyclohexane. 2 g of product are obtained in the form of a white solid., 2346-26-1

The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI-AVENTIS; US2007/21426; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95530-58-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95530-58-8,(R)-4-Isopropyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

caproyl chloride is reacted with the Evans valine-derived oxazolidinone, (R)-4-isopropyloxazolidin-2-one, and n-butylLi (Step a). The resulting adduct (2) is reacted by aldol condensation with a chiral aldehyde derived from (S)-(-)-lactic acid (3) in the presence of dibutyl-BOTf and triethylamine (Step b). The 4-hydroxyl group of the resulting adduct (4) is protected as a t-butyldimethylsilyl ether (using TBS chloride and DIEA), followed by peroxide-mediated hydrolysis (using hydrogen peroxide and lithium hydroxide) of the chiral auxiliary to yield the differentially protected dihydroxy pentanoic acid (5) (Steps c and d). Differential protection of the two secondary alcohols allows for the incorporation of various carboxylic acids at the 3 position of the lactone. The carboxylic acid is coupled to N-FMOC-L-threonine benzyl ester with BOP-chloride and DMAP (Step e). Removal of the two benzyl protecting groups with H2 and Pd/O will yield the dilactone seco-acid (6) (Step f). Lactonization occurs using a BOP-Cl mediated ester-forming reaction with DMAP (Step g). Diethylamine is used to remove the FMOC protecting group to yield the dilactone (7) (Step h). N-formyl-3-amine salicylic acid is coupled to the dilactone using standard carbodiimide chemistry (Step i). In particular, the dilactone is combined with N-formyl-3-aminosalicylic acid using EDCl and HOBT, followed by treatment with TBAF. The final elaboration of the derivatized antimycin A3 structure is accomplished by fluoride-mediated removal of the silyl protecting group and coupling of the desired acid chloride (e.g., isobutyryl chloride and DIEA) (Steps j and k).

As the paragraph descriping shows that 95530-58-8 is playing an increasingly important role.

Reference£º
Patent; Fred Hutchinson Cancer Research Center; US2005/239873; (2005); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

WORKING EXAMPLE 15 In substantially the same manner as in Working Example 11, (E,E)-5-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]-2,4-pentadien-1-al was condensed with 2,4-oxazolidinedione. The condensate was subjected to catalytic hydrogenation to yield 5-[5-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]pentyl]-2,4-oxazolidinedione. The product was recrystallized from dichloromethane-ether to give colorless prisms, m.p.114-115 C., 2346-26-1

As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5932601; (1999); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

80-65-9, (b) 0.5 g (2.0 mmol) of Compound II was dissolved in 10 ml of methanol, 0.24 g (2.4 mmol) of Furazolidone metabolites AOZ, at 60 ~ 70 reaction 2h, the reaction was completed, cooled to room temperature, filtered to give 0.32g furazolidone metabolite haptens. The structural formula III of the hapten and the synthetic route thereof are shown in FIG. 1.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Runkun Biological Technology Co., Ltd.; Hu Rui; Li Bin; (14 pag.)CN106866568; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem