Heterocyclic Building Blocks-Oxazolidine

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80-65-9

[Example 1] 4-fluoro-N-(2-oxo-oxazolidin-3-yl)benzamide (Compound 1) 0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25ml three-necked flask, 10ml water was added, and 0.92g (5.9mmol) 4-fluorobenzoyl chloride was added slowly dropwise at room temperature, the reactiong system was stirred overnight. White precipitate was precipitated, filtrated under vacuum, and recrystallized in ethanol to get white solid (Compound 1) 0.61g, with a yield of 56%. 1H-NMR(400MHz,DMSO)deltappm:10.87(1H,s),7.97(2H,t,J=4.0Hz,J=4.0Hz),7.40 (2H,t,J=8.0Hz,J=12.0Hz),4.46(2H,t,J=8.0Hz,J=8.0Hz), 3.79(2H,t,J=8.0Hz,J=8.0Hz); EI-MS(m/z):225.1[M+H]+; m.p.189-192C.

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
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95530-58-8,95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The R type EvansAuxiliary base addedTo 250 ml of dry reaction flask,70 ml of anhydrous THF dissolved,Cooled to -78 C,And then slowly adding n-BuLi (18.5 ml, 46.3 mmol)After 30 min reaction,(E) -2-methyl-2-butenoyl chloride (5.0 g, 42.5 mmol) was added and reacted for 30 min. The temperature was raised to 0 C and the reaction was continued for 15 min.20ml saturated ammonium chloride quenching reaction, separationThe organic phase was extracted with ethyl acetate (20 ml x 3). The organic phases were combined, washed with saturated brine (40 ml), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure.The residue was subjected to column chromatography (elution conditions, petroleum ether: ethyl acetate = 10: 1) to give the product as a white solid, 7.7 g, 94% yield;

The synthetic route of 95530-58-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Lei Xinsheng; Lin Guoqiang; Zhao Qun; Xu Qianqian; Shan Guangsheng; (20 pag.)CN104418707; (2017); B;,
Oxazolidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.

6.2 Synthesis of tert-butyl (4S)-2,2-dimethyl-4-(morpholin-4-ylcarbonyl)- 1,3- oxazolidine-3-carboxylate a62.; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (740 mg, 3.86 mmol, 1.1 eq) and 1-hydroxybenzotriazole hydrate (522 mg, 3.86 mmol, 1.1 eq) are added to a cold solution (00C) of (4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1 ,3-oxazolidine-4-carboxylic acid a61 (860 mg, 3.50 mmol, 1 eq) and morpholine (336 mul, 3.86 mmol, 1.1 eq) in N1N- dimethylformamide (30 ml). The mixture is stirred at room temperature for 6 hours and concentrated to dryness. The residue is dissolved in a 0.5 N aqueous solution of hydrochloric acid and extracted three times with dichloromethane. The combined organic phases are washed with a saturated solution of sodium hydrogenocarbonate, dried over magnesium sulfate and concentrated under vacuum to afford 991 mg of tert-butyl (4S)-2,2- dimethyl-4-(morpholin-4-ylcarbonyl)-1 ,3-oxazolidine-3-carboxylate a62 as a yellow solid. Yield: 90 %. LC-MS (MH+): 315., 139009-66-8

The synthetic route of 139009-66-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB PHARMA S.A.; WO2008/128919; (2008); A2;,
Oxazolidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.,452339-73-0

Sodium hydride (60% oil dispersion, 1.26 g) was added to a stirred, cooled (ice-bath) solution of (5R)-5- (4H-1, 3-benzodioxin-6-yl)-2-oxazolidinone (5.47 g) in dry DMF (50 ML) under nitrogen and the mixture was stirred for 15 min at 5 C. A solution of 6-bromohexyl 4- (3-IODOPHENYL) BUTYL ether (10.7 g) in DMF (30 ml) was then added dropwise over 10 min. The mixture was stirred for 2 h at ambient temperature, then poured into aqueous solution of ammonium chloride and extracted into ethyl acetate. The combined extracts were washed with water, dried (NA2SO4) and evaporated. The residue was purified on a biotage cartridge (90 g) eluting with ether-hexane (3: 2) to give the title compound (9.8 g). LCMS RT= 4.20 min.

452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/39762; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25 ml three-necked flask, 10ml 1,2-dimethoxyethane was added, and 1.2g (5.9mmol) n-butyl isocyanate was slowly added dropwise, and then after 30 mins, white solid was precipitated, and the mixture was heated under refluxing for 15 mins, filtrated under vacuum, and recrystallized in isopropanol, to get 0.61g white solid (Compound 15), with a yield of 62%. 1H-NMR(400MHz,DMSO)deltappm:8.01(1H,s),6.69(1H,s),4.30(2H,t,J=8.0Hz,J=8.0Hz ),3.59(2H,t,J=8.0Hz,J=8.0Hz),3.00(2H,m),1.37(2H,m),1.25(2H,m),0.87(3H,m);EI-MS( m/z): 202.2[M+H]+; m.p. 98-100C.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

497-25-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.

General procedure: In a two-neck round-bottom flask equipped with a stir-bar, CuCl2 (0.2 equiv), oxazolidin-2-one (5.0 equiv), Na2CO3 or Cs2CO3 (2.0 equiv) and molecular sieve (4) were combined. The reaction flask was purged with oxygen for 15 min. A solution of pyridine (2.0 equiv) in dry toluene (0.2 M) was added to the reaction flask via a syringe at room temperature. Two balloons filled with oxygen were connected to the reaction flask via a needle. The flask was placed in an oil-bath and heated to 70 C. A solution of alkyne (1.0 equiv) in dry toluene was added over 4 h using a syringe pump. After the addition was completed, the reaction mixture was stirred at 70 C for 8 h and then cooled to room temperature. The crude mixture was concentrated under vacuum and the residue was purified by flash chromatography on silica gel.

The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lingua, Hugo; Vibert, Francois; Mouysset, Dominique; Siri, Didier; Bertrand, Michele P.; Feray, Laurence; Tetrahedron; vol. 73; 25; (2017); p. 3415 – 3422;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147959-19-1,(S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

n-BuLi (2 M in hexane, 1.7 mL, 3.45 mmol, 1.5 eqv.) was added to a stirred suspension of methyltriphenylphosphonium bromide (1.23 g, 3.45 mmol, 1.5 eqv.) in dry THF (10 mL) under argon at 0 C dropwise over 5 min, and the resulting solution was allowed to stir for 20 min at 0 C. A solution of the aldehyde 4 (560 mg, 2.30 mmol) in THF (5 mL) was then added dropwise over 5 min with stirring at the same temperature. After 20 min, the solution was allowed to come to room temperature and stirred for another 4 h. The reaction mixture was quenched by addition of aq NH4Cl solution (3 mL) and then extracted with ethyl acetate (2 x 50 mL). The combined organic extract was washed successively with H2O (40 mL) and brine solution (40 mL) and then dried over MgSO4. It was then filtered, and the filtrate was concentrated under reduced pressure to leave the crude product which was purified by column chromatography over silica gel (EtOAc-PE, 1:19) to give the olefin 1b as a colourless liquid (410 mg, 74 %)., 147959-19-1

147959-19-1 (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate 10586317, aoxazolidine compound, is more and more widely used in various.

Reference£º
Article; Chattopadhyay, Shital K.; Kundu, Indranil; Synthetic Communications; vol. 44; 14; (2014); p. 2112 – 2120;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 6 (0.100 g, 0.433 mmol), appropriate substituted phenol (0.649 mmol) and PPh3 (0.182 g,0.693 mmol) in anhydrous toluene (5 mL) was added DIAD(0.14 mL, 0.693 mmol) at 80 C. After 3 h, EtOAc (40 mL)was added to the resulting solution. The organic layer was washed with 0.5 M aqueous NaOH (40 mL) and water (2 X40 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash silica gel column chromatography eluting with Hexanes/EtOAc (9:1) or (95:5) to afford compounds 7a-s., 108149-63-9

The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Andrade, Saulo F.; Campos, Edmar F.S.; Teixeira, Claudia S.; Bandeira, Cristiano C.; Lavorato, Stefania N.; Romeiro, Nelilma C.; Bertollo, Caryne M.; Oliveira, Monica C.; Souza-Fagundes, Elaine M.; Alves, Ricardo J.; Medicinal Chemistry; vol. 10; 6; (2014); p. 609 – 618;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

A solution of tert-butyl (4R)-4-(hydroxymethyl)-2-methyl-1,3-oxazolidine-3-carboxylate (9.38 g, 43.17 mmol, 1.00 equiv), Cs2CO3 (28.1 g, 86.24 mmol, 2.00 equiv), and methyl prop-2-enoate (18.6 g, 216.05 mmol, 5.00 equiv) in ACN (80 mL) was stirred for 3 h at room temperature. The solids were filtered out and the residue was concentrated under vacuum to afford 9.92 g of the title compound as a crude yellow oil LCMS (ESI, m/z): 318.18 [M+H]+

108149-63-9, 108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Ribon Therapeutics Inc.; Vasbinder, Melissa Marie; Schenkel, Laurie B.; Swinger, Kerren Kalai; Kuntz, Kevin Wayne; (410 pag.)US2019/330194; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 1 A mixture of (E)-4-[2-[5-methyl-2-(3-methylphenyl)-4-oxazolyl]ethoxy]cinnamaldehyde (1.20 g), 2,4-oxazolidinedione (0.525 g), piperidine (0.09 g) and ethanol (20 ml) was heated for 5 hours under reflux. The reaction mixture was poured into water, which was acidified with 2N HCl, followed by extraction with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4) and, then, concentrated. The concentrate was purified by means of a silica gel column chromatography. From the fractions eluted with chloroform-methanol (50:1) was obtained 5-[4-[2-[5-methyl-2-(3-methylphenyl)-4-oxazolyl]ethoxy]cinnamylidene]-2,4-oxazolidinedione (0.51 g, 34%). Recrystallization from dichloromethane-methanol gave pale yellow prisms, m.p.213-214 C.

2346-26-1, 2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5665748; (1997); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem