Heterocyclic Building Blocks-Oxazolidine

152305-23-2, (S)-4-(4-Aminobenzyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(S)-4-(4-Aminobenzyl)-l,3-oxazolidin-2-one (IX) (100 g) was charged in water (400 ml, 4.0 volumes) and cone. HCl (200 ml, 2.0 volumes) was added at 25-30¡ãC. The solution was cooled to 5 to -10¡ãC and a solution of sodium nitrite (54 g, 1.5 equivalents) in water (400 ml, 4.0 volumes) was added whilst maintaining the temperature below -5¡ãC. After completion of the addition, the reaction mixture was stirred for 3 hours resulting in the formation of the diazonium chloride (XV) in solution.

152305-23-2, As the paragraph descriping shows that 152305-23-2 is playing an increasingly important role.

Reference£º
Patent; GENERICS [UK] LIMITED; MYLAN DEVELOPMENT CENTRE PRIVATE LIMITED; WO2009/44211; (2009); A1;,
Oxazolidine – Wikipedia
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108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

108149-63-9, Serinol derivative 5 (65 mg, 0.28 mmol) was dissolved in dry DMSO (3 mL) and treated with NaH (5 mg, 60% dispersion in mineral oil, 0.21 mmol) and mesylate 39 (100 mg, 0.14 mmol) was added sequentially. The reaction immediately changed color from nearly colorless to orange red. The reaction was stirred at room temperature for 16 h, and was then quenched by the ice and diluted with ethyl acetate. The two layers were separated and the aqueous layer extracted with ethyl acetate (5 15 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo. Purification by flash column chromatography (70:30 petroleum ether/EtOAc) yielded the serinol ether 40 (105 mg, 65%) as colorless oil:

The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Das, Shyamsundar; Induvadana, Boddeti; Ramana; Tetrahedron; vol. 69; 7; (2013); p. 1881 – 1896;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95715-86-9, Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

95715-86-9, In stageA harvesting (R) -2,2- dimethyl – oxazolidine-3,4-dicarboxylic acid 3-t- butyl ester 4-methyl ester (11.4g, 44.0mmol) was dissolved in dichloromethane (100mL), added at -78 Diisopropyl aluminum hydride (1.5M in toluene, 66mL). The temperature was raised to room temperature and stirred for 18 hours. After completion of the reaction, methanol (20 mL) and sodium hydroxide (1N, 200mL) was slowly added to the organic solution is then extracted with methylene chloride, dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure and the residue was separated by column chromatography the title compound were harvested (9.7g, 95%).

The synthetic route of 95715-86-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Life Sciences Ltd.; Park, Heui Sul; Koo, Sun Young; Kim, Hyoung Jin; Lee, Sung Bae; Kwak, Hyo Shin; Artemov, V.; Kim, Soon Ha; (34 pag.)CN105636956; (2016); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

131685-53-5, (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a tetrahydrofuran solution (12.0 mL) containing (S) -4-benzyl-3-propionyloxazolidin-2-one (a1) (1.12 g, 4.81 mmol) was added sodium bis (trimethylsilyl ) Amide in tetrahydrofuran (1.0 M, 9.6 mL, 9.61 mmol) was added dropwise. After stirring the reaction mixture at -78 C. for 15 minutes, a solution of (2E, 4E) -1-bromohexa-2,4-diene (b1) (1.55 g, 9.61 mmol) and tetrabutylammonium iodide (177 mg, 0.481 mmol) was added, the temperature was raised to room temperature, and the mixture was stirred for 1 hour. Saturated ammonium chloride aqueous solution was added to the reaction system at 0 C. to stop the reaction, ethyl acetate was added and the organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain a crude product. The resulting crude product was purified by column chromatography to give (S) -3 – ((R, 4E, 6E) -2-methylocta-4,6-dienoyl) -4- benzyloxazolidin- (1.31 g, 87%).

131685-53-5, The synthetic route of 131685-53-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOKYO UNIVERSITY OF SCIENCE FOUNDATION; JAPANESE FOUNDATION FOR CANCER RESEARCH; SHIINA, ISAMU; YAMORI, TAKAO; (60 pag.)JP6143266; (2017); B2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

NaH (265 mg, 6.63 mmol) was added to a yellow solution of (S)-1-Boc-2,2-dimethyl-4-hydroxymethyloxazolidine (AstaTech Inc., Bristol, Pa.) (1 g, 4.19 mmol) in THF (10 ml). Then the mixture was stirred for 15 min at ambient temperature. The Methyliodid (323 muL, 5.19 mmol) was added to the yellow suspension and the mixture was stirred for 2 h 30 at rt. Then water was added to quench the reaction. The solvent was removed. The residue was purified by flash chromatography (DCM/MeOH: 5%?10% MeOH) to give the title compound (1.013 g, 94%). ESI-MS: 246.1 [M+H]+ (LC-MS 1); 1H NMR (400 MHz, ) delta ppm 1.48 (s, 9H) 1.53 (br. s., 6H) 3.30 (m, 1H) 3.36 (s, 3H) 3.41-3.63 (m, 2H) 3.88-4.00 (m, 2H)

108149-63-9, 108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; NOVARTIS AG; CARAVATTI, Giorgio; FAIRHURST, Robin Alec; FURET, Pascal; STAUFFER, Frederic; SEILER, Frank Hans; MCCARTHY, Clive; RUEEGER, Heinrich; US2013/225574; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

147959-19-1, (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

With key building block 6 in hand, its nitroaldol (Henry) reaction with nitromethane was examined (Table 1). LiAlH418- TBAF19- as well as t-BuOK20-catalyzed Henry reactions led to nitro alcohols 12 and 13 with low diastereoselectivity, reflecting that the existing stereogenic center is too far away from the newly created one to exert appreciable asymmetric induction (Table 1, entries 1-3).21 An obvious way of resolving this problem was the introduction of additional chiral information, i.e. application of a chiral catalyst. In fact double stereodifferentiation using Shibasaki’s well established heterobimetallic (,S)-BINOL catalyst 1422 (5 mol%, THF, -40 C, 3 d) led to 12 with high diastereoselectivity albeit in low yield (Table 1, entry 4).Recently, other highly efficient chiral catalysts for asymmetric Henry reactions have been developed. Thus, Corey23 and Maruoka24 have utilized chiral quaternary ammonium fluorides as catalysts while Trost25 has presented a dinuclear zinc catalyst. Salen-cobalt(II) complexes have been used by Yamada whereas J¡ãrgensen and Evans have introduced bis(oxazoline)-coprhoer(II) complexes. The latter seemed to be the catalysts of choice, at least for aliphatic aldehydes, with respect to attainable yields and degree of stereoselectivity. EPO Table 1. Diastereoselective Henry Reaction of Aldehyde 6 with Nitromethaneyield ratio0 entry catalyst conditions(%)a 12:131 LiAlH4 THF, rt 53 56:442 TBAF THF, rt 33 43:573 r-BuOK t- 72 23:77BuOH/THF,00C4 14 THF, -40 C 45 98:25 {Cu[(+> EtOH, rt 87 92:815]} (OAc)26 (CuK-)- EtOH, rt 85 9:9115]}(OAc)27 {Cu[(+> EtOH, rt 94 97:316]}(OAc)28 (Cu[(-)- EtOH, rt 91 8:9216I)(OAc)2a isolated yield b determined by HPLC analysis of crude reaction mixtures EPO Indeed application of Evans’ bis(oxazoline) copper(II) acetate-based catalysts {Cu[(+)- 15]}(OAc)2 and in particular {Cu[(+)-16]}(OAc)2 (5 mol%, EtOH, rt, 5 d) gave the desired nitro alcohol 12 both with high diastereoselectivity and in high yield (Table 1 , entries 5 and 7). Finally, to obtain selectively diastereomer 13, aldehyde 6 was reacted with nitromethane in the presence of the enantiomeric catalysts {Cu[(-)-15]}(OAc)2 and {Cu[(-)-16]} (OAc)2 respectively. In these cases slightly lower stereoselectivities and yields were observed reflecting a mismatched pairing (Table 1, entries 6 and 8)., 147959-19-1

The synthetic route of 147959-19-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN; WO2006/94770; (2006); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem