Heterocyclic Building Blocks-Oxazolidine

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part II – Synthesis of [(S)-l-(3-chloro-benzenesulfonyl)-3-(2,4-dioxo-oxazolidin-3- ylmethyl)-2,3-dihydro-lH-p ester [0335] To a solution of (91 mg, 0.2 mmol ) [(i?)-l-(3-chloro-benzenesulfonyl)-3- hydroxymethyl-2,3-dihydro-lH-pyrido[2,3-b][l,4]oxazin-7-yl]-carbamic acid tert-butyl ester), oxazolidine-2,4-dione (20 mg, 0.20 mmol), triphenylphosphine (78.6 mg, 0.30 mmol) in THF (2 mL) was added diisopropylazodicarboxylate (60.6 mg, 0.30 mmol) and the mixture was stirred for 12 hours at room temperature. The solvent was removed under reduced pressure and the residue was purified by silica gel chromatography eluting with a gradient of hexane:ethyl acetate (5: 1 to 1 : 1) to afford the title compound (ESI) m/z 539.1.

2346-26-1, As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine; WO2013/169704; (2013); A2;,
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108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

108149-63-9, General procedure: To a stirred solution of 6 (0.100 g, 0.433 mmol), appropriate substituted phenol (0.649 mmol) and PPh3 (0.182 g,0.693 mmol) in anhydrous toluene (5 mL) was added DIAD(0.14 mL, 0.693 mmol) at 80 C. After 3 h, EtOAc (40 mL)was added to the resulting solution. The organic layer was washed with 0.5 M aqueous NaOH (40 mL) and water (2 X40 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash silica gel column chromatography eluting with Hexanes/EtOAc (9:1) or (95:5) to afford compounds 7a-s.

As the paragraph descriping shows that 108149-63-9 is playing an increasingly important role.

Reference£º
Article; Andrade, Saulo F.; Campos, Edmar F.S.; Teixeira, Claudia S.; Bandeira, Cristiano C.; Lavorato, Stefania N.; Romeiro, Nelilma C.; Bertollo, Caryne M.; Oliveira, Monica C.; Souza-Fagundes, Elaine M.; Alves, Ricardo J.; Medicinal Chemistry; vol. 10; 6; (2014); p. 609 – 618;,
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Oxazolidine | C3H7NO – PubChem

108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (R)-4-Hydroxymethyl-2,2-dimethyl-oxazolidine-3 -carboxylic acid tert-butylester (0.66 g, 2.86 mmol) and DMF was added NaH (14 mg, 2 equiv.). After 5 mm., 1-Bromo-4-fluorobenzene 99% (0.31 ml, 2.86 mmol) was added. The mixture was then warmed to 80 C. After 16 h, the flask was cooled and to it added water and extracted with EtAOc. The organic layers are washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. Flash column chromatography was carried out using Hexanes – EtOAc to isolate tert-butyl (R)-4-((4-bromophenoxy)methyl)-2,2-dimethyloxazolidine-3 -carboxylate. [M+ 11 = 387.3., 108149-63-9

The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
Oxazolidine – Wikipedia
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2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

WORKING EXAMPLE 14 In substantially the same manner as in Working Example 11, 3-isopropoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)cinnamaldehyde was condensed with 2,4-oxazolidinedione. The condensate was subjected to catalytic hydrogenation to yield 5-[3-[3-isopropoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione, which was recrystallized from ethyl acetate-hexane to give colorless needles, m.p.120-121 C., 2346-26-1

2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5932601; (1999); A;,
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16251-45-9, (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2a (4S,5R)-3-(Bromoacetyl)-4-methyl-5-phenyloxazolidin-2-one Production is carried out analogously to Example 1a) starting from (4S,5R)-4-methyl-5-phenyloxazolidin-2-one. The coverage of NMR is identical to 1a)., 16251-45-9

The synthetic route of 16251-45-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KLAR, ULRICH; SCHWEDE, WOLFGANG; SKUBALLA, WERNER; BUCHMANN, BERND; US2003/144523; (2003); A1;,
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131685-53-5, (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(76a) (S)-4-Benzyl-3-[(2R,4E)-6-benzyloxy-2-methylhex-4-enoyl]oxazolidin-2-one 164 ml of a solution of sodium bis(trimethylsilyl)amide in n-hexane (1.03 mol/l) (169 mmol) was added to a solution of 32.9 g of (S)-4-benzyl-3-propionyloxazolidin-2-one (141 mmol) in tetrahydrofuran (330 ml) under a nitrogen atmosphere and at -78C over 45 minutes, and the mixture was stirred at the same temperature for 30 minutes. Then, a solution of 35.5 g of [(E)-4-bromobut-2-enyloxymethyl]benzene obtained in Reference Example 4 (148 mmol) in tetrahydrofuran (80 ml) was added to the solution over 30 minutes, and the mixture was stirred at the same temperature for 30 minutes. Thereafter, the mixture was raised to -40C and further stirred for four hours. 100 ml of a saturated ammonium chloride aqueous solution was added to the reaction mixture, and the mixture was further stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure and diluted with 500 ml of water, followed by extraction with ethyl acetate. Then, the organic layer was washed with water and brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (elution solvent: n-hexane/ethyl acetate = 7/1 – 2/1) to obtain 37.9 g of the title compound (yield: 69%). Colorless liquid. 1H NMR spectrum (CDCl3, 400 MHz), delta: 7.40-7.14 (m, 10H), 5.75 (dt, 1H, J = 15.6 Hz, 6.3 Hz), 5.69 (dt, 1H, J = 15.6 Hz, 5.4 Hz), 4.71-4.63 (m, 1H), 4.49 (s, 2H), 4.22-4.11 (m, 2H), 3.98 (d, 2H, J = 5.5 Hz), 3.92-3.81 (m, 1H), 3.28 (dd, 1H, J = 13.3 Hz, 3.1 Hz), 2.67 (dd, 1H, J = 13.3 Hz, 10.2 Hz), 2.58-2.49 (m, 1H), 2.30-2.21 (m, 1H) 1.19 (d, 3H, J = 6.7 Hz).

131685-53-5, The synthetic route of 131685-53-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2036896; (2009); A1;,
Oxazolidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95715-86-9,Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate,as a common compound, the synthetic route is as follows.,95715-86-9

A solution of LiOH (0.046 g, 1.928 mmol) in water (2 mL) was added to a solution of (S)-3-tert-butyl 4-methyl 2,2-dimethyloxazolidine-3,4-dicarboxylate (0.5 g, 1.928 mmol) in THF (6 mL). The resulting mixture was stirred at rt for 48 h, acidified to pH 4 with a 1 N aqueous solution of hydrochloric acid and extracted three times with ethyl acetate. The combined organic phases were dried (MgSO4), filtered and concentrated under vacuum to afford Cap L-25 (0.2 g) as a yellow oil. Used without further purification.1H NMR (400 MHz, DMSO-d6, mixture of rotomers) delta 12.72 (br. s., 1H), 4.33-4.23 (m, 1H), 4.18-4.09 (m, 1H), 3.93 (dt, J=9.0, 3.3 Hz, 1H), 1.56-1.51 (m, 3H), 1.42 (s, 7H), 1.39-1.33 (m, 6H);13C NMR (101 MHz, DMSO-d6, mixture of rotomers) delta 172.32-171.83 (m), 150.7, 93.76-93.42 (m), 79.66-79.01 (m), 65.94-65.54 (m), 58.79-58.57 (m), 28.05-27.74 (m, 3C), 24.93-24.75 (m), 24.16-23.99 (m).

95715-86-9 Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate 688220, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Hewawasam, Piyasena; Lopez, Omar D.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Kadow, John F.; Meanwell, Nicholas A.; Gupta, Samayamuthula Venkata Satya Arun Kumar; Kumar, Indasi J. Gopi; Ponugupati, Suresh Kumar; Belema, Makonen; US2015/23913; (2015); A1;,
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108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,3-Dichloro-A/’-(5-chloro-3-methoxypyrazmyl)-A^-[[2-(trimethylsilyl)ethoxy]methyl]-benzenesulfonamide (0.25g) and (4108149-63-9

108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; ASTRAZENECA AB; WO2004/108692; (2004); A1;,
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80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80-65-9

Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%. 1H NMR (400 MHz, DMSO-d6) delta 10.16 (s, 1H), 7.07 (t,J 12 Hz, 2H), 6.92 (d, J 12 Hz, 2H), 4.36 (t, J 8.0 Hz, 2H), 3.93 (t,J 8.0 Hz, 2H), 3.63 (t, J 8.0 Hz, 2H), 2.26 (t, J 8.0 Hz, 2H), 1.97-1.86 (m, 2H); 13C NMR (DMSO-d6): delta 171.81, 158.02, 157.65, 129.72,124.48, 116.62, 68.15, 62.06, 46.36, 33.34, 28.78, 25.46, 25.02. HRMS(ESI) m/z: calcd. for C13H15FN2O4 [M + H]: 283.1094, found:283.1088.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131685-53-5,(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.

To a solution of (+)-(S)-4-benzyl-3-propyl-2-oxazolidinone (3.00 g, 12.9 mmol) in DCM (70.0 mL) was added 1.0 M dibutylboron triflate in DCM (14.2 mL, 14.2 mmol) and Et3N (2.69 mL, 19.3 mmol) at -78 oC, and then stirring was continued for 30 min at -40 oC. To the reaction mixture cooled to -78 oC was added a solution of 4-benzyloxy-3-methoxybenzaldehyde (3.40 g, 14.2 mmol) in DCM (60.0 mL). After stirring for 11 h, the reaction was quenched by addition of phosphoric buffer (15.4 mL), methanol (51.5 mL), and 30% H2O2 (15.4 mL) at 0 oC. The mixture was stirred for 1 h. The aqueous layer was extracted with DCM and the combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (hexane:AcOEt = 2:1) to afford 5 (4.88 g, 80%, 98% de) as colorless solid: 1H NMR (400 MHz, CDCl3) delta 7.40-7.43 (2H, m), 7.24-7.35 (6H, m), 7.17-7.19 (2H, m), 6.92 (1H, d, J = 1.7 Hz), 6.83 (1H, d, J = 8.0 Hz), 6.80 (1H, dd, J = 8.0, 1.7 Hz), 5.14 (2H, s), 4.97 (1H, d, J = 4.7 Hz), 4.49 (1H, dddd, J = 9.6, 8.4, 3.4, 2.4 Hz), 4.11 (1H, qd, J = 6.8, 4.7 Hz), 4.08 (1H, dd, J = 9.0, 2.4 Hz), 3.94 (1H, dd, J = 9.0, 8.4 Hz), 3.86 (3H, s), 3.22 (1H, dd, J = 13.3, 3.4 Hz), 2.74 (1H, dd, J = 13.3, 9.6 Hz), 1.25 (3H, d, J = 6.8 Hz); 13C NMR (100 MHz, CDCl3) delta 176.5, 152.9, 149.5, 147.4, 137.1, 135.0, 134.5, 129.4, 129.0, 128.5, 127.8, 127.4, 127.3, 118.3, 113.5, 109.7, 74.0, 70.9, 66.1, 56.0, 55.3, 44.6, 37.8, 11.4; IR (ATR) 3509, 1775, 1695 cm-1; EIMS (rel. int.) m/z 475 [M]+(1), 91 (100); HREIMS calcd 475.1995 for C28H29O6N, found 475.1979; [alpha]D20 +58.9 (c 1.00, CHCl3); m.p. 117.0 oC., 131685-53-5

As the paragraph descriping shows that 131685-53-5 is playing an increasingly important role.

Reference£º
Article; Harada, Kenichi; Horiuchi, Hiroki; Tanabe, Kazuma; Carter, Rich G.; Esumi, Tomoyuki; Kubo, Miwa; Hioki, Hideaki; Fukuyama, Yoshiyasu; Tetrahedron Letters; vol. 52; 23; (2011); p. 3005 – 3008;,
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