Heterocyclic Building Blocks-Oxazolidine

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Oxazole( cas:288-42-6 ) is researched.COA of Formula: C3H3NO.Cao, Zhu; Zhang, Huihui; Wu, Xinxin; Li, Yahong; Zhu, Chen published the article 《Radical heteroarylation of unactivated remote C(sp3)-H bonds via intramolecular heteroaryl migration》 about this compound( cas:288-42-6 ) in Organic Chemistry Frontiers. Keywords: heteroarenyl alkanol regioselective radical heteroarylation; heteroaryl alkanone preparation. Let’s learn more about this compound (cas:288-42-6).

The radical-mediated heteroarylation of unactivated remote C(sp3)-H bonds via intramol. heteroaryl migration is achieved, leading to a variety of heteroaryl-substituted aliphatic ketones. A library of O-/S-/N-containing heteroaryls such as benzofuryl, benzothiazolyl, benzothienyl, benzoxazolyl, oxazolyl and thiazolyl are amenable to the migration approach. The heteroaryl migration was triggered by an azido radical-mediated hydrogen atom abstraction from unactivated aliphatic C(sp3)-H bonds. The transformation features mild C-C bond cleavage, good selectivity for tertiary C(sp3)-H bonds and broad functional group compatibility.

《Radical heteroarylation of unactivated remote C(sp3)-H bonds via intramolecular heteroaryl migration》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Oxazole)COA of Formula: C3H3NO.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione. Author is Kushtaev, Aleksandr A.; Yudin, Nikolai V.; Zbarskii, Vitol’d L.; Zhilin, Viktor F..

The nitration kinetics of 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methoxy-2-methyl-imidazolidone-4,5-dione was investigated. The hydrolysis kinetics of 2-(dinitro-methylene)-5,5- dinitro-pyrimidine-4,6(1 H,3H,5H)-dione and 2-(dinitro-methylene)-imidazolidone-4,5-dione has been studied. These results can be used for 1,1-diamino-2,2-dinitro-ethene technol. creation.

《Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H7BClNO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Pyridin-3-ylboronic acid hydrochloride, is researched, Molecular C5H7BClNO2, CAS is 265664-63-9, about Pyridinium boronic acid salts in crystal synthesis. Author is Kara, Hulya; Adams, Christopher J.; Orpen, A. Guy; Podesta, Thomas J..

Salts of pyridinioboronic acids, [HNC5H4B(OH)2-4]2[M(S2C2O2)2]·2H2O (M = Cu 1, Ni 2, Pd 3, Pt 4), [HNC5H4B(OH)2-4]2[Pt(O2C2O2)2] (5); [HNC5H4B(OH)2-3]2 [M(S2C2O2)2] (M = Cu 6, Ni 7, Pd 8, Pt 9) and [HNC5H4B(OH)2-3]2[Pt(O2C2O2)2] (10) were prepared and characterized by x-ray diffraction methods. Salts 2, 3 and 4 are isostructural and isomorphous and contain H-bonded supermols. [pyridinium]2[M(S2C2O2)2] linked by BOH···OB and B(OH)-H2O H bonds into a three-dimensional network. Anhydrous salt 5 has a different structure in which the ions are linked by R(2,2)8 B(OH)2···carboxylate and pyridinium···carboxylate interactions to form a planar H-bonded ribbon. Salts 6, 7, 8 and 10 are all isostructural and isomorphous and contain H-bonded supermols. [pyridinium]2[M(S2C2O2)2] linked by B(OH)2···carboxylate synthons to form a stepped chain. These chains pack in layers superimposed so as to afford short metal···metal contacts of length 3.6-4 Å between layers. The structure of 5 is isomorphous with that of salts 6-8 and 10 but with a different pattern of NH H bonding as a result of the different isomer of pyridinioboronic acid present.

《Pyridinium boronic acid salts in crystal synthesis》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridin-3-ylboronic acid hydrochloride)Computed Properties of C5H7BClNO2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of Ethyl 3-bromo-2-oxopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Comparative evaluation of the inhibitory potential of synthetic N-heterocycles, Cu/Fe3O4@SiO2 nanocomposites and some natural products against non-resistant and antibiotic-resistant Acinetobacter baumannii. Author is Mardaneh, Jalal; Beyzaei, Hamid; Hashemi, Seyed Hadi; Ghasemi, Behzad; Rahdar, Abbas.

Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii. Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values. Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024μg ml-1) and MBCs (128-2048μg ml-1). Among synthetic chems. and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathol. effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.

Different reactions of this compound(Ethyl 3-bromo-2-oxopropanoate)Reference of Ethyl 3-bromo-2-oxopropanoate require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,6-Dichloropurine(SMILESS: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2,cas:5451-40-1) is researched.Related Products of 1194-22-5. The article 《System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:5451-40-1).

The worldwide circulation of different viruses coupled with the increased frequency and diversity of new outbreaks, strongly highlight the need for new antiviral drugs to quickly react against potential pandemic pathogens. Broad-spectrum antiviral agents (BSAAs) represent the ideal option for a prompt response against multiple viruses, new and re-emerging. Starting from previously identified anti-flavivirus hits, we report herein the identification of promising BSAAs by submitting the multi-target 2,6-diaminopurine chemotype to a system-oriented optimization based on phenotypic screening on cell cultures infected with different viruses. Among the synthesized compounds, 6i showed low micromolar potency against Dengue, Zika, West Nile and Influenza A viruses (IC50 = 0.5-5.3μM) with high selectivity index. Interestingly, 6i also inhibited SARS-CoV-2 replication in different cell lines, with higher potency on Calu-3 cells that better mimic the SARS-CoV-2 infection in vivo (IC50 = 0.5μM, SI = 240). The multi-target effect of 6i on flavivirus replication was also analyzed in whole cell studies (in vitro selection and immunofluorescence) and against isolated host/viral targets.

Different reactions of this compound(2,6-Dichloropurine)Reference of 2,6-Dichloropurine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Conference, Kratk. Tezisy – Vses. Soveshch. Probl. Mekh. Geteroliticheskikh Reakts. called Reaction of 4,6-dioxopyrimidines with sodium bisulfite, Author is Kheifets, G. M., which mentions a compound: 1194-22-5, SMILESS is CC1=NC(=CC(N1)=O)O, Molecular C5H6N2O2, Product Details of 1194-22-5.

4,6-Dioxopyrimidines form bisulfite adducts at the 2 position, but the equilibrium is shifted strongly toward the adduct only when no substituent is present at the 2 or 5 position. The rate of the forward reaction of the unsubstituted compound proceeds through a maximum as the pH is varied from 2 to 7. The rate-determining steps for the forward and reverse reactions of the different dioxopyrimidines are discussed.

Different reactions of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Product Details of 1194-22-5 require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis, structure, and properties of oligo-tridentate ligands; covalently assembled precursors of coordination arrays.Category: oxazolidine.

Oligo-tridentate ligands based on alternating pyridines and pyrimidines, e.g., I (R = H, Ph, 9-anthryl, R’ = H, Me, CH2Br) and II (R = H, Me, Ph), were synthesized by Stille-type carbon-carbon bond-forming reactions. The terpyridine-like sites are designed to coalign upon metal complexation, giving rise to organized and rigidly spaced metal ions. Peripheral functionalization of the basic bis-tridentate framework was explored. The heterocycles in the ligands are in an all-trans conformation about the interannular bonds as indicated by comparison of their 1H NMR spectra. An x-ray crystal structure anal. of the nonchiral tris-tridentate ligand II (R = H) reveals a helical structure in the solid state. The seven heterocycles form a helical structure with resulting overlap of the terminal pyridines. Their centroid-to-centroid distance is 4.523 Å with 38.8° between the planes. NMR investigations support a helical conformation in solution as well. Electrochem. and UV absorption measurements indicate that the LUMO resides on the pyrimidine moiety of the ligands.

Different reactions of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Category: oxazolidine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Quality Control of Oxazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Evaluation of Mongolian compound library for potential antimalarial and anti-Toxoplasma agents. Author is Banzragchgarav, Orkhon; Ariefta, Nanang R.; Murata, Toshihiro; Myagmarsuren, Punsantsogvoo; Battsetseg, Badgar; Battur, Banzragch; Batkhuu, Javzan; Nishikawa, Yoshifumi.

179 Compounds in a Mongolian compound library were investigated for their inhibitory effect on the in vitro growth of Plasmodium falciparum and Toxoplasma gondii. Among these compounds, brachangobinan A at a half-maximal inhibition concentration (IC50) of 2.62μM and a selectivity index (SI) of 27.91; 2-(2-hydroxy-5-O-methylphenyl)-5-(2,5-dihydroxyphenyl)oxazole (IC50 3.58μM and SI 24.66); chrysosplenetin (IC50 3.78μM and SI 15.26); 4,11-di-O-galloylbergenin (IC50 3.87μM and SI 13.38); and 2-(2,5-dihydroxyphenyl)-5-(2-hydroxyphenyl)oxazole (IC50 6.94μM and SI 11.48) were identified as potential inhibitors of P. falciparum multiplication. Addnl., tricin (IC50 12.94μM and SI > 23.40) was identified as a potential inhibitor of T. gondii multiplication. Our findings represent a good starting point for developing novel antimalarial and anti-Toxoplasma therapeutics from Mongolian compounds

Different reactions of this compound(Oxazole)Quality Control of Oxazole require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about One-pot electrochemical synthesis of highly symmetric and conjugated coumarin derivative, the main research direction is hydroxyphenyl piperazinyl ethanone hydroxy dimethylcoumarin one pot electrochem oxidation; dihydroxy phenylene bishydroxy dimethylchromenone preparation.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

A facile and one pot electrochem. synthesis of disubstituted hydroquinone generated from the electrochem. oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of 4-hydroxy-6,7-dimethylcoumarin was reported. The results revealed that p-quinone imine derived from oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone participated in Michael addition reactions with 4-hydroxy-6,7-dimethylcoumarin and followed by a hydrolysis reaction attain to the highly sym. and conjugated coumarin derivative A new product in good yield was derived based on controlled potential electrochem. oxidation at carbon electrode in a divided cell.

Different reactions of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors, published in 2014, which mentions a compound: 67914-60-7, Name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, Molecular C12H16N2O2, Related Products of 67914-60-7.

The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and PB2, is a promising target for the development of new antiviral drugs. A large library of benzofurazan compounds was synthesized and assayed against influenza virus A/WSN/33 (H1N1). Most of the new derivatives were found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1. Docking studies were also performed to elucidate the binding mode of benzofurazans within the PB1 binding site in PA and to identify amino acids involved in their mechanism of action. The predicted binding pose is fully consistent with the biol. data and lays the foundation for the rational development of more effective PA-PB1 inhibitors.

Different reactions of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Related Products of 67914-60-7 require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem