Heterocyclic Building Blocks-Oxazolidine

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Biological Significance of Imidazole-based Analogues in New Drug Development, the main research direction is review biol significance imidazole new drug development anticancer heterocyclic; Imidazole; analgesic and anti-inflammatory; anti-tubercular; anticancer; antiviral; heterocyclic.Safety of Oxazole.

A review. In the field of heterocyclic medicinal chem., especially five-membered ring structures containing a nitrogen atom, imidazole core is an imperative aromatic heterocycle which is usually present in naturally occurring products and synthetic bioactive mols. The occurrence of imidazole moiety in therapeutic compounds may be beneficial in terms of improving water-soluble properties due to its two nitrogen atoms which leads to the creation of hydrogen bonds. The imidazole nucleus has also been recognized as an important isostere of triazole, pyrazole, thiazole, tetrazole, oxazole, amide etc. for the purpose of designing and development of various biol. active mols. Moreover, imidazole core as an attractive binding site could interact with diverse cations and anions as well as biomols. through different reactions in the human biol. system thus displaying extensive biol. activities. This effort thoroughly provides a wide-ranging assessment in current drug discovery and developments of imidazolebased analogs in the entire series of synthetic medicinal chem. as antibacterial and antifungal, anticancer, anti-tubercular, analgesic and anti-inflammatory, anti-neuropathic, antihypertensive, anti-allergic, anti-parasitic, antiviral, antidepressant, anti-obesity and so on, altogether with their prospective approaches in diagnostic and pathol. field. It is expected that the present review will be supportive on behalf of new opinions in the search for rational strategies of more efficacious and less toxic medicinal agents and drugs containing imidazole core.

Different reactions of this compound(Oxazole)Safety of Oxazole require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 5451-40-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about The Direct Decarboxylative N-Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis.

A method for direct decarboxylative C-N coupling of carboxylic acids RC(O)OH (R = naphthalen-1-yl, 2-phenylpropan-2-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, etc.) with a range of nitrogen nucleophiles, e.g., 5-(4-bromophenyl)-2H-1,2,3,4-tetrazol-2-yl has been described. This platform employs visible-light-mediated photoredox catalysis and an iodine(III) reagent to generate carbocation intermediates directly from aliphatic carboxylic acids via a radical-polar crossover mechanism. A variety of C-N bond-containing products, e.g., I are constructed from a diverse array of nitrogen heterocycles, including pyrazoles, imidazoles, indazoles, and purine bases. Furthermore, sulfonamides, ureas, and carbamates can also be utilized as a nucleophile to generate a selection of N-alkylated products. Notably, a two-step approach to construct free amines directly from the carboxylic acids is accomplished using Cbz-protected amine as a nucleophile.

Different reactions of this compound(2,6-Dichloropurine)Recommanded Product: 5451-40-1 require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Hubbard, Troy D.; Liu, Qing; Murray, Iain A.; Dong, Fangcong; Miller, Charles; Smith, Philip B.; Gowda, Krishne; Lin, Jyh Ming; Amin, Shantu; Patterson, Andrew D.; Perdew, Gary H. published an article about the compound: 2,6-Dichloropurine( cas:5451-40-1,SMILESS:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2 ).Recommanded Product: 2,6-Dichloropurine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:5451-40-1) through the article.

The aryl hydrocarbon receptor (AHR) is a major regulator of immune function within the gastrointestinal tract. Resident microbiota are capable of influencing AHR-dependent signaling pathways via production of an array of bioactive mols. that act as AHR agonists, such as indole or indole-3-aldehyde. Bacteria produce a number of quinoline derivatives, of which some function as quorum-sensing mols. Thus, we screened relevant hydroxyquinoline derivatives for AHR activity using AHR responsive reporter cell lines. 2,8-Dihydroxyquinoline (2,8-DHQ) was identified as a species-specific AHR agonist that exhibits full AHR agonist activity in human cell lines, but only induces modest AHR activity in mouse cells. Addnl. dihydroxylated quinolines tested failed to activate the human AHR. Nanomolar concentrations of 2,8-DHQ significantly induced CYP1A1 expression and, upon cotreatment with cytokines, synergistically induced IL6 expression. Ligand binding competition studies subsequently confirmed 2,8-DHQ to be a human AHR ligand. Several dihydroxyquinolines were detected in human fecal samples, with concentrations of 2,8-DHQ ranging between 0 and 3.4 pmol/mg feces. Addnl., in mice the microbiota was necessary for the presence of DHQ in cecal contents. These results suggest that microbiota-derived 2,8-DHQ would contribute to AHR activation in the human gut, and thus participate in the protective and homeostatic effects observed with gastrointestinal AHR activation.

Different reactions of this compound(2,6-Dichloropurine)Recommanded Product: 2,6-Dichloropurine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1194-22-5, is researched, Molecular C5H6N2O2, about Photochemical transformations of 4,6-dihydroxypyrimidine and 2-methyl-4,6-dihydroxypyrimidine isolated in low-temperature Ar, Ne and H2 matrices, the main research direction is hydroxypyrmidine photoisomerization vibrational frequency UV IR spectra.SDS of cas: 1194-22-5.

Monomers of 4,6-dihydroxypyrimidine and 2-methyl-4,6-dihydroxypyrimidine were trapped from the gas phase into low-temperature Ar, Ne and normal-H2 matrixes. Dihydroxy and oxo-hydroxy tautomers were identified. The isolated monomers were exposed to UV (285 > λ > 270 nm) radiation. For the mols. isolated in Ar and Ne matrixes, such UV excitation led to conversion of the oxo-hydroxy tautomer into three products: the dihydroxy form, the Dewar isomer and the open-ring ketene. In solid-hydrogen matrixes, UV-induced oxo-hydroxy → dihydroxy hydrogen-atom-transfer conversion did not occur; the UV-excited oxo-hydroxy form of the investigated compounds transformed only to the Dewar and open-ring ketene products.

Different reactions of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)SDS of cas: 1194-22-5 require different conditions, so the reaction conditions are very important.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Oxazole( cas:288-42-6 ) is researched.Name: Oxazole.Qian, Lu; Tang, Xixia; Huang, Zhidao; Wang, Yulei; Liu, Guixia; Huang, Zheng published the article 《Chiral Iridium Complexes of Anionic NCP Pincer Ligand for Asymmetric Transfer Hydrogenation of 1,1-Diarylethenes with Ethanol》 about this compound( cas:288-42-6 ) in Organic Letters. Keywords: oxazolinylphosphinoxyphenyl iridium pincer complex preparation catalyst asym hydrogenation arylethene; crystal structure oxazolinylphosphinoxyphenyl iridium pincer complex bromophenylmethoxyphenylethane; mol structure oxazolinylphosphinoxyphenyl iridium pincer complex bromophenylmethoxyphenylethane. Let’s learn more about this compound (cas:288-42-6).

Chiral Ir complexes ligated by anionic oxazoline-bearing NCP-type pincer ligands were developed and applied to the asym. transfer hydrogenation (ATH) of diarylethenes using environmentally benign EtOH as the H donor. High enantioselectivities could be achieved for substrates bearing ortho-Me, ortho-Cl, or ortho-Br substituents on one of the aryl groups. The ATH of ortho-Br-substituted diarylethenes is particularly attractive due to the propensity of the C(aryl)-Br bond to undergo various new bond-forming events.

Different reactions of this compound(Oxazole)Name: Oxazole require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Assemblies of polyacrylonitrile-derived photoactive polymers as blue and green light photo-cocatalysts for Cu-catalyzed ATRP in water and organic solvents, published in 2021, which mentions a compound: 7789-45-9, Name is Cupric bromide, Molecular Br2Cu, Name: Cupric bromide.

Photoluminescent nanosized quasi-spherical polymeric assemblies prepared by the hydrothermal reaction of polyacrylonitrile (PAN), ht-PLPPAN, were demonstrated to have the ability to photo-induce atom transfer radical polymerization (ATRP) catalyzed by low, ppm concentrations of CuII complex with tris(2-pyridylmethyl)amine (TPMA). Such photo induced ATRP reactions of acrylate and methacrylate monomers were performed in water or organic solvents, using ht-PLPPAN as the photo-cocatalyst under blue or green light irradiation Mechanistic studies indicate that ht-PLPPAN helps to sustain the polymerization by facilitating the activation of alkyl bromide species by two modes: (1) green or blue light-driven photoreduction of the CuII catalyst to the activating CuI form, and (2) direct activation of dormant alkyl bromide species which occurs only under blue light. The photoreduction of the CuII complex by ht-PLPPAN was confirmed by linear sweep voltammetry performed under illumination. Anal. of the polymerization kinetics in aqueous media indicated even though CuI complexes comprised only 1-1.4% of all Cu species at equilibrium, they exhibited high activation rate constant and activated the alkyl bromide initiators five to six orders of magnitude faster than ht-PLPPAN.

The article 《Assemblies of polyacrylonitrile-derived photoactive polymers as blue and green light photo-cocatalysts for Cu-catalyzed ATRP in water and organic solvents》 also mentions many details about this compound(7789-45-9)Name: Cupric bromide, you can pay attention to it, because details determine success or failure

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

HPLC of Formula: 288-42-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles. Author is Lozano, Cedric; Ramirez, Cristian; Sin, Ny; Viart, Helene M.-F.; Prusiner, Stanley B.; Paras, Nick A.; Conrad, Jay.

In the literature, C-N coupling methods for the reaction of iodo-oxazole with 2-pyridinone were found to be low yielding. C-N coupling using silver benzoate additives with CuI catalysts and 4,7-dimethoxy-1,10-phenanthroline ligands has been developed to afford synthetically useful yields of the desired heterobicycle product. The reaction conditions are applied to the coupling of a range of iodo-heterocycles with 2-pyridinone. The coupling of a variety of NH-containing heterocycles with 4-iodo-oxazole is also demonstrated. The use of 2-, 4-, or 5-iodo-oxazole allows for the coupling of pyridinone to each oxazole position.

The article 《Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles》 also mentions many details about this compound(288-42-6)HPLC of Formula: 288-42-6, you can pay attention to it, because details determine success or failure

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Formula: C12H16N2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Synthesis of 6-[4-(4-Propoxyphenyl)piperazin-1-yl]-9H-purine Derivatives as Antimycobacterial and Antifungal Agents: In Vitro Evaluation and In Silico Study.

A series of novel alkyl substituted purines were synthesized. 6-[4-(4-Propoxyphenyl)piperazin-1-yl]-9H-purine was used as the key starting material, which was synthesized via a multistep protocol and finally subjected for N-alkylation with various alkyl halides with an aim to get prospective antimicrobial agents. The structures of the novel compounds were established by substantiating them through spectral techniques like 1H-NMR, 13C-NMR, FT-IR and EI-MS. They were explored for antitubercular activity against Mycobacterium tuberculosis H37RV. Furthermore, they were checked for their antimicrobial activity concerning bacterial and fungal strains. The title compounds exhibited considerable antimicrobial activity without any significant toxicity. In silico studies depicted their good binding profile against Mycobacterium tuberculosis enoyl reductase (InhA; PDB ID: 4TZK) and Candida albicans dihydrofolate reductase (PDB ID: 1AI9). The title compounds obeyed Lipinski’s parameters and have exhibited good drug-like properties.

The article 《Synthesis of 6-[4-(4-Propoxyphenyl)piperazin-1-yl]-9H-purine Derivatives as Antimycobacterial and Antifungal Agents: In Vitro Evaluation and In Silico Study》 also mentions many details about this compound(67914-60-7)Formula: C12H16N2O2, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

SDS of cas: 5451-40-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Three-in-one: information encryption, anti-counterfeiting and LD-tracking of multifunctional purine derivatives. Author is Wang, Hao-Yuan; Yu, Kang-Kang; Tan, Chong-Yun; Li, Kun; Liu, Yan-Hong; Shi, Lei; Lu, Kai; Yu, Xiao-Qi.

It is still a challenge to develop new intelligent multifunctional fluorescence reagents with high brightness, high optical stability, and high contrast fluorescence based on small mols. In this study, by building push-pull electronic structures and adjusting the number of carbazole groups and the length of the alkyl chain, a series of multifunctional mols. based on a purine-core has been successfully synthesized and achieved the improvement of the fluorescence quantum yield. Furthermore, the relationship between the structure and optical properties of these purine derivatives has been investigated from multiple perspectives. Moreover, the most promising mol. (CPPC) exhibits high fluorescence quantum yield, high brightness, high optical stability, and high contrast fluorescence, and it has been successfully applied in information encryption, anti-counterfeiting and LD-tracking of living cells. The present study offers a novel and efficient approach to develop multifunctional fluorescence materials with high performance based on purine.

The article 《Three-in-one: information encryption, anti-counterfeiting and LD-tracking of multifunctional purine derivatives》 also mentions many details about this compound(5451-40-1)SDS of cas: 5451-40-1, you can pay attention to it, because details determine success or failure

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H2Cl2N4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Nucleobase derivatives induce in-source decay of oligonucleotides as new matrix-assisted laser desorption/ionization matrices.

Rationale : For quality control of oligonucleotide therapeutics, accurate and efficient structural characterization using mass spectrometry techniques, such as liquid chromatog./mass spectrometry (LC/MS) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), is essential. In MALDI MS anal., matrix selection is critical and a new matrix could enable more efficient and rapid structural anal. Methods : We hypothesized that nucleobase derivatives could act as matrixes more efficiently than the currently used matrixes for oligonucleotides because of structural similarity, which leads to close contact with the analyte. To evaluate their suitability as matrixes, 16 nucleobase derivatives were selected and tested as matrix candidates for oligonucleotide anal. Results : Six of the 16 nucleobase derivatives acted as matrixes for oligonucleotides. Particularly, 6-thioguanine (TG) performed well and induced clear in-source decay fragmentation. When TG or 2-amino-6-chloropurine was used as the matrix, oligonucleotides were ionized, and mainly the w and d fragment ions were observed Conclusions : Herein we demonstrate that a 10-mer RNA or DNA sequence can be successfully characterized using TG as matrix and suggest the possibility of using nucleobase derivatives as novel matrixes in oligonucleotide sequencing.

The article 《Nucleobase derivatives induce in-source decay of oligonucleotides as new matrix-assisted laser desorption/ionization matrices》 also mentions many details about this compound(5451-40-1)Computed Properties of C5H2Cl2N4, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem