Heterocyclic Building Blocks-Oxazolidine

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Amani, Amene; Khazalpour, Sadegh; Nematollahi, Davood researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.They published the article 《Electrochemical oxidation of 4-(piperazin-1-yl)phenols in the presence of indole derivatives: The unique regioselectivity in the synthesis of highly conjugated bisindolyl-p-quinone derivatives》 about this compound( cas:67914-60-7 ) in Journal of Electroanalytical Chemistry. Keywords: electrooxidation piperazinylphenol indole derivative regioselectivity electrosynthesis conjugated bisindolyl quinone. We’ll tell you more about this compound (cas:67914-60-7).

The electrochem. oxidation of 4-(piperazin-1-yl)phenols were studied in the presence of indole derivatives as nucleophiles in H2O/MeCN mixture by cyclic voltammetry and controlled-potential coulometry. The reaction mechanism is believed to be oxidation of 4-(piperazin-1-yl)phenols, Michael addition reaction, oxidation of the formed adduct, another Michael addition reaction, oxidation of new adduct and hydrolysis (ECECEC). Bisindolyl-p-quinones were synthesized through the regioselective addition of indoles to electrochem. generated quinone imines in good yields at C electrode in a divided cell.

The article 《Electrochemical oxidation of 4-(piperazin-1-yl)phenols in the presence of indole derivatives: The unique regioselectivity in the synthesis of highly conjugated bisindolyl-p-quinone derivatives》 also mentions many details about this compound(67914-60-7)Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Cocrystal structure, thermal behavior, and DFT calculations between FOX-7 and 1,10-Phenanthroline. Author is Li, Keyao; Ren, Xiangwen; Fu, Shuqin; Zhu, Jiaping.

Cocrystal of FOX-7 (1,1-diamino-2,2-dinitroethene) and Phen (1,10-Phenanthroline) has been synthesized and characterized by X-ray crystallog. The single crystal results show that FOX-7 and its cocrystal were crystallized in the monoclinic space groups P21/n and P21/c, resp. Thermal stability of FOX-7 and FOX-7·Phen were studied by DSC, the first exothermic peak temperatures (TP) of FOX-7 and FOX-7·Phen occurs at 223.2 and 232.7 °C, resp.; indicating that FOX-7·Phen is more stable than FOX-7. Thermokinetic parameters such as the activation energy Ea and pre-exponential factor A were 321.4 kJ mol-1 and 1.166 x 1033 s-1, resp. DFT studies including geometry optimization, HOMO-LUMO anal., Mulliken charge and UV-visible spectral data were also calculated by DFT-B3LYP/6-31 + G** level.

The article 《Cocrystal structure, thermal behavior, and DFT calculations between FOX-7 and 1,10-Phenanthroline》 also mentions many details about this compound(1194-22-5)Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of Ethyl 3-bromo-2-oxopropanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines. Author is Reddy, Ramesh B.; Dudhe, Premansh; Chelvam, Venkatesh.

In the last two decades, tubulysins have emerged as alternatives to microtubule depolymerizing agents such as colchicine and vinblastine, which are well-established anticancer agents. However, the complex structure of tubulysins has always posed a challenge for synthetic chemists to scale up the production of these compounds We report a new strategy for the practical gram-scale synthesis of a (4R)-4-[( tert-butoxycarbonyl)amino]-5-methylhexanoic acid through regioselective cleavage of a chiral aziridine ring with a vinyl Grignard reagent to afford tert-Bu [(1R)-1-isopropylbut-3-en-1-yl]carbamate, which was subjected to regioselective hydroboration-oxidation with 9-BBN. The resulting (4R)-4-[( tert-butoxycarbonyl)amino]-5-methylhexanoic acid was successfully transformed into the deacetoxytubuvaline fragment of pretubulysin or its highly lipophilic methyl-substituted thiazole and oxazole analogs for incorporation into pretubulysins. Increasing the lipophilicity of tubulysin or pretubulysin mols. should enhance their cell permeability and cytotoxicity in cancer cell lines.

The article 《Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines》 also mentions many details about this compound(70-23-5)Safety of Ethyl 3-bromo-2-oxopropanoate, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about New process for synthesis of 1-acetyl-4-(4-hydroxyphenyl)piperazine. Author is Zheng, Chun-zhi; Zhang, Guo-hua; Jiang, Da-feng.

The synthesis of the target compound was achieved (37.5% overall yield) by a sequence involving a chlorination, cyclization and acylation using bis(2-chloroethyl)amine hydrochloride and aminophenol as reactants. The product thus obtained [i.e., 1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone] was confirmed by IR, 1H-NMR.

After consulting a lot of data, we found that this compound(67914-60-7)Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Infrared spectra of the biological molecule 4,6-dihydroxy-2-methylpyrimidine, the main research direction is IR spectra hydroxymethylpyrimidine; pyrimidine derivative IR spectra.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

The IR absorption spectra of 4,6-dihydroxy-2-methylpyrimidine were recorded spectrophotometrically in the region 250-4000 cm-1 using KBr and Nujol mull techniques. The spectra were analyzed assuming C2v point group symmetry for the mol. The assignments were proposed and discussed and the tautomeric behavior of the mol. was also discussed.

After consulting a lot of data, we found that this compound(1194-22-5)Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Precise Control of Both Dispersity and Molecular Weight Distribution Shape by Polymer Blending, published in 2021-08-23, which mentions a compound: 7789-45-9, Name is Cupric bromide, Molecular Br2Cu, HPLC of Formula: 7789-45-9.

The breadth and the shape of mol. weight distributions can significantly influence fundamental polymer properties that are critical for various applications. However, current approaches require the extensive synthesis of multiple polymers, are limited in dispersity precision and are typically incapable of simultaneously controlling both the dispersity and the shape of mol. weight distributions. Here we report a simplified approach, whereby on mixing two polymers (one of high D and one of low D), any intermediate dispersity value can be obtained (e.g. from 1.08 to 1.84). Unrivalled precision is achieved, with dispersity values obtained to even the nearest 0.01 (e.g. 1.37→1.38→1.39→1.40→1.41→1.42→1.43→1.44→1.45), while maintaining fairly monomodal mol. weight distributions. This approach was also employed to control the shape of mol. weight distributions and to obtain diblock copolymers with high dispersity accuracy. The straightforward nature of our methodol. alongside its compatibility with a wide range of polymerization protocols (e.g. ATRP, RAFT), significantly expands the toolbox of tailored polymeric materials and makes them accessible to all researchers.

After consulting a lot of data, we found that this compound(7789-45-9)HPLC of Formula: 7789-45-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of Cupric bromide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Studying anion-dependent paradoxically fluorescent Cu(II) complexes bearing a pyridine-decorated tetradentate half-salamo-like ligand. Author is Han, Xiu-Juan; Li, Ruo-Yu; Yue, Yong-Ning; Zhang, Yang; Dong, Wen-Kui.

A new pyridine-decorated half-salamo-like ligand (HL) was designed and synthesized by a one-pot method. Based on this ligand, the single crystals of three anion-dependent Cu(II) complexes [Cu(L)Cl]·CH3OH (1), [Cu(L)Br] (2) and [Cu(L)(NO3)] (3) have been cultivated successfully and the structural features were determined by single crystal x-ray diffraction analyses. The results showed that the complexes 1, 2 and 3 have homologous mononuclear structures, in which the five-coordinated Cu(II) atom is not only surrounded by the N3O cavity of the ligand (L)- unit, but also coordinated with Cl-, Br- and NO-3 as auxiliary coordination, resp. The ligand HL and the complexes 1, 2 and 3 were characterized via elemental analyses, IR and UV-Vis spectroscopy. The short-range interactions of the complexes 1, 2 and 3 were investigated by Hirshfeld surfaces analyses. Furthermore, DFT calculations were investigated in the complexes 1, 2 and 3. Paradoxically, the fluorescence intensities of these Cu(II) complexes are significantly increased compared to the ligand.

After consulting a lot of data, we found that this compound(7789-45-9)Safety of Cupric bromide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

COA of Formula: C5H7BrO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Fragment-Based Ligand Discovery Using Protein-Observed 19F NMR: A Second Semester Organic Chemistry CURE Project. Author is Bur, Scott K.; Pomerantz, William C. K.; Bade, Morgan L.; Gee, Clifford T..

Curriculum-based undergraduate research experiences (CUREs) have been shown to increase student retention in STEM fields and are starting to become more widely adopted in chem. curricula. Here we describe a 10-wk CURE that is suitable for a second-semester organic chem. laboratory course. Students synthesize small mols. and use protein-observed 19F (PrOF) NMR to assess the small mol.’s binding affinity to a target protein. The research project introduced students to multistep organic synthesis, structure-activity relationship studies, quant. biophys. measurements (measuring Kd from PrOF NMR experiments), and scientific literacy. Docking experiments could be added to help students understand how changes in a ligand structure may affect binding to a protein. Assessment using the CURE survey indicates self-perceived skill gains from the course that exceed gains measured in a traditional and an inquiry-based laboratory experience. Given the speed of the binding experiment and the alignment of the synthetic methods with a second-semester organic chem. laboratory course, a PrOF NMR fragment-based ligand discovery lab can be readily implemented in the undergraduate chem. curriculum.

After consulting a lot of data, we found that this compound(70-23-5)COA of Formula: C5H7BrO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Related Products of 1194-22-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Pyrazine chemistry. Part 9. Oxygenation of pyrazines and pyrimidines. Author is Markham, Janet L.; Sammes, Peter G..

Irradiation of pyrazines I (R = CH2Ph, Me) and pyrimidines II (R = EtO, Me) in the presence of O and sensitizer gave the resp. endo peroxides III and IV in high yield. Mild NaBH4 reduction of III (R = Me) gave a mixture of cis and trans diols V whereas treatment with acid gave the parent pyrazine.

After consulting a lot of data, we found that this compound(1194-22-5)Related Products of 1194-22-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Discovery of selective and nonpeptidic cathepsin S inhibitors. Author is Irie, Osamu; Ehara, Takeru; Iwasaki, Atsuko; Yokokawa, Fumiaki; Sakaki, Junichi; Hirao, Hajime; Kanazawa, Takanori; Teno, Naoki; Horiuchi, Miyuki; Umemura, Ichiro; Gunji, Hiroki; Masuya, Keiichi; Hitomi, Yuko; Iwasaki, Genji; Nonomura, Kazuhiko; Tanabe, Keiko; Fukaya, Hiroaki; Kosaka, Takatoshi; Snell, Christopher R.; Hallett, Allan.

Nonpeptidic, selective, and potent cathepsin S inhibitors were derived from an inhouse pyrrolopyrimidine cathepsin K inhibitor by modification of the P2 and P3 moieties. The pyrrolopyrimidine-based inhibitors show nanomolar inhibition of cathepsin S with over 100-fold selectivity against other cysteine proteases, including cathepsin K and L. Some of the inhibitors showed cellular activities in mouse splenocytes as well as oral bioavailabilities in rats.

After consulting a lot of data, we found that this compound(67914-60-7)Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem