Heterocyclic Building Blocks-Oxazolidine

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: Design, synthesis, and microbiological evaluation, the main research direction is benzothiazine ketoconazole analog preparation antifungal QSAR.HPLC of Formula: 67914-60-7.

As a part of a program to develop novel antifungal agents, new compounds which incorporate the 1,4-benzothiazine moiety into the structure of ketoconazole (KTZ) were prepared These compounds were computationally investigated to assess whether the 1,4-benzothiazine moiety was a suitable bioisosteric replacement for the 2,4-dichlorophenyl group of KTZ in order to obtain a more potent inhibition of CYP51 enzyme of Candida albicans. Results of preliminary microbiol. studies show that the racemic cis-7 analog has a good in vivo activity, comparable to that of KTZ, but the best activity was observed in the racemic trans-7 analog.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70-23-5, is researched, Molecular C5H7BrO3, about Green production and antioxidant activity study of new pyrrolo[2,1-a]isoquinolines, the main research direction is phthaldehyde primary amine bromoalkane acetylene carboxylate four component reaction; pyrroloisoquinoline preparation antioxidant green chem; chromenoindolizine preparation; pyranopyrroloisoquinoline preparation.Category: oxazolidine.

In current research, pyrrolo[2,1-a]isoquinolines, compounds I [R1 = CN; R2 = CO2Et, 4-BrC6H4, etc.; R3 = H, CO2Me, CO2Et; R4 = Me, Et; X1 = H, Me, MeO; X2 = H, Me] were synthesized via a new process of four-component reaction of phthalaldehyde or its derivatives, primary amines, alkyl bromides, activated acetylenic compounds and potassium fluoride/Clinoptilolite nanoparticles (KF/CP NPs) under solvent-free conditions at room temperature Also, Diels-Alder reactions took place in the reaction of synthesized pyrrolo[2,1-a]isoquinoline derivatives, activated acetylenic compounds and triphenylphosphine in the presence of KF/CP NPs under solvent-free conditions at room temperature As well, antioxidation property of some prepared pyrrolo[2,1-a]isoquinolines were investigated by employing trapping of diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment Among investigated compounds, compounds I [R1 = CN, R2 = 4-MeC6H4, R3 = CO2Me, R4 = Me, X1 = H, X2 = Me] have good results relative to BHT and TBHQ as standard antioxidant. Reported method has good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In these reactions, KF/Clinoptilolite nanoparticles show a satisfactory recyclable activity.

Compounds in my other articles are similar to this one(Ethyl 3-bromo-2-oxopropanoate)Category: oxazolidine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Efficient factors on the hydrolysis reaction rate of some para-aminophenol derivatives in acidic pHs. Author is Beiginejad, Hadi; Nematollahi, Davood; Varmaghani, Fahimeh; Bayat, Mehdi.

Electrochem. oxidation of some p-aminophenol derivatives (1-5) in acidic solutions was studied both exptl. and theor. to provide insight into the influence of some factors on the hydrolysis reaction rate. The result of this work shows that the electrogenerated p-quinoneimines participate in the hydrolysis reaction and are converted to the p-benzoquinone. The hydrolysis reaction rate strongly depends on the structure of the p-aminophenols and solution’s pH. The observed homogeneous rate constants of hydrolysis (kobshyd) of p-quinoneimines were determined using digital simulation technique. The effect of different parameters such as: change of Gibbs free energy (ΔG) of the electrochem. oxidation of para-aminophenol derivatives (1-5), charge of reaction site, N-C4 bond order (Wiberg Bond Indexes, WBIs) and the nature of substituted group, on the hydrolysis rate constant were also studied. All calculations were performed using D. Functional Theory (DFT) both BP86 and B3LYP levels of theory and 6-311G (p,d) basis set. The N-C4 bond order and charge on the reaction site play significant roles in hydrolysis reaction’s rate.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organic Process Research & Development called The development of a commercial manufacturing route to 2-fluoroadenine, the key unnatural nucleobase of islatravir, Author is Hong, Cynthia M.; Xu, Yingju; Chung, John Y. L.; Schultz, Danielle M.; Weisel, Mark; Varsolona, Richard J.; Zhong, Yong-Li; Purohit, Akasha K.; He, Cyndi Q.; Gauthier, Donald R. Jr.; Humphrey, Guy R.; Maloney, Kevin M.; Levesque, Francois; Wang, Zhixun; Whittaker, Aaron M.; Sirota, Eric; McMullen, Jonathan P., which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, Application In Synthesis of 2,6-Dichloropurine.

Synthesis of a key fragment of islatravir (MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and pre-exposure prophylaxis (PrEP) against HIV infection was discussed. The fragment, the unnatural nucleobase 2-fluoroadenine, was incorporated into MK-8591 via a biocatalytic aldol-glycosylation cascade, which imposed stringent requirements for its synthesis and isolation. Presented herein was the development work leading to a practical, scalable route from guanine, featuring a dual fluorination approach to a novel 9-THP-2,6-difluoropurine intermediate that enables a mild, highly selective, direct amination. This one-pot fluorination/amination sequence utilized a direct isolation to deliver high purity 9-THP-2-fluoroadenine, which features ideal properties with respect to reactivity, solubility, and crystallinity. An acid-catalyzed liberation of 2-fluoroadenine in aqueous buffer delivers the appropriate purity profile to facilitate the enzymic cascade to access MK-8591.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Soleimani-Amiri, Somayeh; Shafaei, Faezeh; Varasteh Moradi, Ali; Gholami-Orimi, Fathali; Rostami, Zohreh published the article 《A Novel Synthesis and Antioxidant Evaluation of Functionalized [1,3]-Oxazoles Using Fe3O4-Magnetic Nanoparticles》. Keywords: cyclopenta oxazole thione green preparation radical trapping ferric reduction; oxazole thione preparation bromo ketone isothiocyanate cyclization; magnetic iron oxide nanoparticle catalyst preparation.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Synthetic Route of C5H7BrO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

In this research, green procedure was employed for biosynthesis of magnetic nanoparticles of iron oxide (Fe3O4-MNPs) by reduction of ferric chloride solution with Orange peel water extract Also, dihydro-2H-cyclopenta[d][1,3]oxazoles I (R = CO2Et, 4-MeOC6H4, 4-MeC6H4, 4-BrC6H4; R1 = t-Bu, 4-MeOC6H4, 4-O2NC6H4; R2 = Me, Et; R3 = CO2Et, 4-MeOC6H4, 4-MeC6H4) were generated through multi-component reaction of 1,3-oxazole-2(3H)-thione, dialkyl acetylenedicarboxylates, α-haloketones, and Fe3O4-MNPs as catalyst at ambient temperature in good yield. Initially, 1,3-oxazole-2(3H)-thione derivatives as one of the precursors are produced through the reaction of alkyl bromides, isothiocyanate, sodium hydride, and Fe3O4-MNPs as catalyst water at ambient temperature in 83-95% yields. Also, diphenyl-picrylhydrazine radical trapping and ferric reduction activity potential assays are used for evaluation of antioxidant activity of some synthesized compounds Among investigated compounds, I (R = CO2Et; R1 = 4-O2NC6H4; R2 = Me; R3 = 4-MeOC6H4) has good power for radical trapping activity and I (R = 4-MeOC6H4; R1 = t-Bu; R2 = Me; R3 = 4-MeC6H4) has good reduction power to butylated hydroxytoluene and 2-tert-butylhydroquinone.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Promising 2,6,9-trisubstituted purine derivatives for anticancer compounds: synthesis, 3D-QSAR, and preliminary biological assays, the main research direction is trisubstituted purine regioselective preparation SAR QSAR antitumor apoptosis human; 3D-QSAR; apoptosis; cancer; cell cycle; cytotoxicity; purine derivatives.Reference of 2,6-Dichloropurine.

Two series of 2,6,9-trisubstituted purine derivatives I [R1 = Et, n-Bu, n-hexyl, etc.; R2 = cyclopentyl, cyclohexyl, cycloheptanyl, etc.] and II [R3 = 4-CF3OC6H4, 4-phenyl-piperidin-1-yl, 4-phenyl-piperazin-1-yl, 4-(4-chlorophenyl)piperazin-1-yl, etc.; R4 = Cl, 5-(nitropyridin-2-yl)piperazin-1-yl, 4-(pyrazin-2-yl)piperazin-1-yl, etc.; R5 = n-pentyl, n-hexyl, cyclopentyl] were synthesized and evaluated for their prospective role as antitumor compounds Compounds I and II were tested for their in vitro cell toxicity on seven cancer cells lines and one non-neoplastic cell line. Structural requirements for antitumor activity on two different cancer cell lines were analyzed with SAR and 3D-QSAR. The 3D-QSAR models showed that steric properties could better explain the cytotoxicity of compounds than electronic properties (70% and 30% of contribution, resp.). From this anal., conclusion was that arylpiperazinyl system connected at position 6 of the purine ring was beneficial for cytotoxic activity, while the use of bulky systems at position C-2 of the purine was not favorable. Compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] was found to be an effective potential agent when compared with a currently marketed drug, cisplatin, in four out of the seven cancer cell lines tested. Compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] showed the highest potency, unprecedented selectivity and complied with all the Lipinski rules. Finally, it was demonstrated that compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] induced apoptosis and caused cell cycle arrest at the S-phase on HL-60 cells.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Quality Control of Cupric bromide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Regenerative magnetic nanoparticle-supported ATRP ligand for bottlebrush copolymer preparation. Author is Jing, Jingyun; Shi, Congling.

A facile method is proposed to prepare functionalized Fe3O4@Me6TREN nanoparticles (NPs) for atom transfer radical polymerization (ATRP). The Me6TREN moieties on NPs surface can bind copper, thus making them effective nano ligands for ATRP reactions to synthesize bottlebrush copolymers. After polymerization, purification of the polymer achieved only by a magnet, is much simpler than traditional ATRP process. No column chromatog. is required. Furthermore, Fe3O4@Me6TREN NPs can thus be regenerated via separating copper from NPs surface by ligand exchange with EDTA-Na2. Such a versatile nano ligand is of great worth to promote the industrial application of ATRP at a large scale and low cost.

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Oxazolidine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Single-chain folding and self-assembling of amphiphilic polyethyleneglycol-modified fluorinated styrene homopolymers in water solution》. Authors are Guazzelli, Elisa; Masotti, Elena; Calosi, Matteo; Kriechbaum, Manfred; Uhlig, Frank; Galli, Giancarlo; Martinelli, Elisa.The article about the compound:Cupric bromidecas:7789-45-9,SMILESS:[Cu+2].[Br-].[Br-]).COA of Formula: Br2Cu. Through the article, more information about this compound (cas:7789-45-9) is conveyed.

Amphiphilic tetrafluorostyrene monomers (EFSn) carrying in the para position a polyethyleneglycol (PEG) chain with varied lengths (n = 3-13) were synthesized and polymerized by ARGET-ATRP to obtain the corresponding amphiphilic homopolymers pEFSn-x with controlled and tailored polymerization degrees (x = 8-135). All polymers presented a reversible thermoresponsive LCST-type behavior, in water/methanol mixture when n ≤ 4 or in pure water when n ≥ 8, with a cloud point (Cp) temperature in the range 30-40°C strictly dependent on the length of the PEG side chain. Combined small angle X-scattering (SAXS) and dynamic light scattering (DLS) measurements were used to study the self-assembly behavior in water of the water-soluble amphiphilic homopolymers. SAXS confirmed the formation of compact-sized and spherical single-chain self-folded nanostructures below Cp, that generally presented small hydrodynamic diameters (Dh ≤ 11 nm) as proven by DLS anal. Above Cp, much larger multi-chain aggregates were formed (Dh ≥ 800 nm), that reversibly turned back to collapsed nanostructures on cooling below the Cp temperature By contrast, the polymers were not able to self-assemble in THF or DMF solutions, in which they adopted conventional random coil conformations.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

HPLC of Formula: 67914-60-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates. Author is Jiang, Xiong-Jie; Huang, Jian-Dong; Zhu, Yu-Jiao; Tang, Fen-Xiang; Ng, Dennis K. P.; Sun, Jian-Cheng.

Two novel axially substituted phthalocyanines, namely bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon (IV) (1) and its N-methylated derivative 2, have been synthesized. The dicationic phthalocyanine 2 is non-aggregated in water and exhibits good photophys. properties. The non-covalent BSA conjugates of these compounds have also been prepared Compound 2 and the conjugate 2-BSA show extremely high photodynamic activities toward B16 melanoma cancer cell lines. The corresponding 50% growth-inhibitory (IC50) ratios are 33 and 38 nM, resp.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 151509-01-2, is researched, SMILESS is O=C(OC)C1=C(CN)N=CC=C1.[H]Cl, Molecular C8H11ClN2O2Journal, Journal of Heterocyclic Chemistry called Synthesis of a new 1,4-dihydropyridine containing the imidazo[1,5-a]pyridine nucleus, Author is Fos, Empar; Bosca, Francisco; Mauleon, David; Carganico, Germano, the main research direction is imidazopyridinyl dihydropyridine preparation calcium channel blocker; antithrombotic imidazopyridinyl dihydropyridine preparation; pyridine imidazopyridinyl preparation; nifedipine imidazopyridinyl analog preparation.Electric Literature of C8H11ClN2O2.

The preparation of the new dihydropyridine di-Et 1,4-dihydro-4-(imidazo[1,5-a]pyridin-8-yl)-2,6-dimethylpyridine-3,5-dicarboxylate (I) is described. After many attempts to prepare the key intermediate aldehyde II by different approaches, this compound was obtained in good yields from Me 2-cyano-3-pyridinecarboxylate. A 3-step procedure involving reduction to the amine, formylation with concomitant cyclization and reduction of the ester group was used. I had activity as calcium antagonist but it was devoid of activity as thromboxane inhibitor.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem