Heterocyclic Building Blocks-Oxazolidine

Category: oxazolidine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Construction of Thermoresponsive Microcapsules for the Controlled Release of Thidiazuron to Improve Defoliation Effects. Author is Feng, Xiantao; Zhu, Yingqiang; Liu, Zhiqing; Meng, Caiye; Yang, Lin; Han, Xiaoqiang; Yang, Jinfeng; Jia, Xin.

The successful defoliation of cotton leaves by using chem. defoliants is extremely important for the mech. harvest of cotton, which can greatly reduce the impurity content of cotton. However, the defoliation effect is seriously affected by temperature Cotton absorbs excessive defoliants at high temperatures, which causes the cotton leaves to be scorched without falling off. We have constructed a smart carrier system through thermoresponsive microcapsules, which can decrease the release of defoliants at high temperatures to avoid an excessive absorption of defoliants by plants so that the absorption of defoliant by the leaves has been maintained at an optimal level. A defoliant microcapsule (TDZ@PDA-g-PMEO2MA) was prepared by loading thidiazuron (TDZ, a widely used defoliant) in a carrier of polydopamine grafted with 2-(2-methoxyethoxy)ethyl methacrylate through a simple phys. adsorption process to study its defoliation effect, with a high loading ratio of 45.9%. The outer polymer brush of the microcapsules can collapse at a high temperature to reduce the release of TDZ, thereby preventing the scorched leaves caused by the excessive absorption of defoliants by cotton. Compared with the com. available TDZ formula (wettable powder), the cotton defoliation ratio is increased by 51.1%, which shows a better defoliation effect. Thermoresponsive microcapsules reduce the excessive absorption of defoliants by cotton by reducing the release of defoliants, which greatly enhances the defoliation effect of cotton at high temperatures The result provides a new idea for how to increase the defoliation ratio at a high temperature

There is still a lot of research devoted to this compound(SMILES：[Cu+2].[Br-].[Br-])Category: oxazolidine, and with the development of science, more effects of this compound(7789-45-9) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

COA of Formula: Br2Cu. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Durable superhydrophobic cotton fabrics prepared by surface-initiated electrochemically mediated ATRP of polyhedral vinylsilsesquioxane and subsequent fluorination via thiol-Michael addition reaction. Author is Li, Hui; Tang, Songsong; Zhou, Qingqing; Chen, Wei; Yang, Xixue; Xing, Tieling; Zhao, Yan; Chen, Guoqiang.

Fluorinated polyhedral oligomeric silsesquioxane (F-POSS) is one of the most popular candidates at present for superhydrophobic coating. Because of its ultralow surface energy, F-POSS has usually been dissolved with expensive fluoro-solvents, and the melting temperature of F-POSS is not high (122-140°C), which will cause its loss during use. So trying to polymerize/crosslink F-POSS mols. and/or directly graft F-POSS to substrate is important. In this work, we report the SI-eATRP grafting of methacryl POSS (MA-POSS) on cotton and the subsequent amine catalyzed thiol-methacrylate Michael addition reaction of poly(MA-POSS) with 1H, 1H, 2H, 2H-perfluorododecyl-1-thiol (PFDT) for the fabrication of a durable poly(MA-POSS)-PFDT coating. The cotton fabric coated with poly(MA-POSS) was nearly superhydrophobic after 4 h of SI-eATRP process under potentiostatic condition of -0.40 V. Although the water contact angle (WCA) was ∼148°, water droplets tended to adhere to the cotton fabric surface even when the fabric was turned upside down. After fluorination, WCA was increased to ∼160°, and water drops could slide off when the fabric was slightly tilted. The sliding angle (SA) was ∼10°. The as-prepared poly(MA-POSS)-PFDT coating was durable against repeated washing and phys. abrasion. After 30 accelerated washing cycles (equals to 150 home laundering cycles), the coated fabric still showed superhydrophobicity. After 800 abrasion cycles over sandpaper, the WCA was still as high as 149°. In addition, the coated fabric had self-healing ability and could restore its superhydrophobicity after plasma etching through heat treatment. After 10 cycles of plasma etching and heat-induced healing process, the WCA of the coated fabric kept at ∼154°. Such a durable superhydrophobic fabric coating may find applications in the development of functional clothing for a variety of purposes.

There is still a lot of research devoted to this compound(SMILES：[Cu+2].[Br-].[Br-])COA of Formula: Br2Cu, and with the development of science, more effects of this compound(7789-45-9) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of Cupric bromide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Spectral studies and quantum chemical ab initio calculations for Copper(II) complexes of two heterocyclic aroylhydrazones. Author is Sheeja, S. R.; Mangalam, Neema Ani; Sithambaresan, M.; Prathapachandra Kurup, M. R.; Kaya, Savas; Serdaroglu, Goncagul.

five copper(II) complexes of quinoline-2-carbaldehyde benzoylhydrazone and a copper(II) complex of 2-benzoylpyridine benzoylhydrazone were synthesized. From the elemental analyses, conductivity measurements and by the determination of magnetic moments, the complexes were formulated. The complexes were characterized by IR, electronic and EPR spectroscopy. From the trend in g values, considerable covalent character is expected to the metal-ligand bonds and also, square pyramidal geometry is suggested for five coordinated complexes. Half field signals observed in the EPR spectra of [Cu(QCB)N3]2·H2O and [Cu2(BPB)2(μ-SO4)], in solid state at 298 K and in frozen solution, confirm the dimeric structure for the complexes. The quantum chem. results obtained from the ab initio calculations for the aroylhydrazones and their Cu(II)- complexes were evaluated to explain the observed reactivity tendency of the compounds

There is still a lot of research devoted to this compound(SMILES：[Cu+2].[Br-].[Br-])Reference of Cupric bromide, and with the development of science, more effects of this compound(7789-45-9) can be discovered.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about On the Synthesis of 1,1-Diamino-2,2-dinitroethene (FOX-7) by Nitration of 4,6-Dihydroxy-2-methylpyrimidine. Author is Latypov, Nikolaj V.; Johansson, Martin; Holmgren, Erik; Sizova, Ekaterina V.; Sizov, Vladimir V.; Bellamy, Anthony J..

The synthesis of 1,1-diamino-2,2-dinitroethene (FOX-7) by nitration of 4,6-dihydroxy-2-methylpyrimidine and hydrolysis of the resulting intermediate 2-dinitromethylene-5,5-dinitropyrimidine-4,6-dione was studied. By varying the reaction parameters the optimal conditions for the synthesis of FOX-7 were identified and gave a >90% yield of the pure product. The optimized process allowed the spent acid to be recycled without loss of yield, with almost stoichiometric consumption of HNO3. The purity of the FOX-7 was determined by using a newly developed HPLC method.

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application of 1194-22-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Influence of some derivatives and isomers of uracil, cytosine, and isocytosine on the growth of transplantable tumors. Author is Aksamitnaya, I. A..

5-Hydroxy-4-methyluracil, 4,5-dihydrouracil, 6-thiouracil, 6-thio-4-methyluracil, 2-methyl-4,6-dihydroxypyrimidine, or 4-amino-6-hydroxypyrimidine at 100-200 mg./ml. suppressed tumor growth by 9-32%, while 6-thiothymine and Na 4-methyl-5-sulfoisocytosine stimulated tumor growth by 33 and 41%, resp., in mice implanted with sarcoma 180 cells. 4-Amino-6-hydroxypyrimidine inhibited and Na 4-methyl-5-sulfoisocytosine stimulated growth of Ehrlich ascites tumors in mice. Thymine, 4-methyluracil, 4-methyl-4,5-dihydrouracil, 4-methylisocytosine, and 4-methyl-5-aminoisocytosine did not affect tumor growth in mice.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Infrared spectra of derivatives of pyrimidine》. Authors are Short, L. N.; Thompson, H. W..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Name: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Graphs of the vibrational spectra between 2 and 25 μ are given for the following compounds suspended as solids in paraffin or perfluorokerosine, and for the deuterio derivatives of the starred compounds (deuteriated by treatment with D2O): pyrimidine, monosubstituted pyrimidines: 2-Cl-, 2-NH*2-, 5-NH2-2-OH-*, 4-OH-*, 2-SH-*; 2,4-disubstituted pyrimidines: Cl2-, (OEt)2, (OPh)2, 2-Cl-4-NH2-*, (OH)2-*, 2-OH-4-NH2-*, (NH2)2-(SH)2-*, 2-SH-4-NH2-, 2(-)SH-4-OH-*; 4,6-disubstituted pyrimidines: 4-NH2-6-Cl-*, 4-OH-6-Me-, (OH)2-, 4-OH-6NH2-*, (NH2)2-*, 2,4,6-trisubstituted pyrimidines: Cl3-, 2-Me-4,6-Cl2-, 2-NH2-4,6-Me*2-2-NH2-4,6-(OMe)2-, 2-NH2-4,6-Cl2-, 2-NH2-4-Me-6-OEt-*, 2-NH2-4-Me-6-Cl-*, 2,6-Cl2-4-NH2-, 2-Cl-4-NH2-6-Me-, 2,6-Me2-4-NH2-*, 2-Me-4-NH2-6-Cl-, 2-NHMe-4-Me-6-Cl-, 2,6-Me2-4-OH-, 2,4-(OH)2-6-Me-, 2-Me-4,6-(OH)2-, (OH)3-, 2-NH2-4-OH-6-Me-*, 2-NMe2-4-OH-6-Me-*, 2-NH2-4-OH-6-Cl-, 2-SMe-4-OH-6-NH2-, 2-Me-4-OH-6-NH2-*, (NH2)3-, 2,4-(OH)2-6-NH2-, 2-NH2-4,6-(OH)2-, 2,4-(NH2)2-6-OH, 2-OH-4,6-(NH2)2-, 2-SH-4-OH-6-Me-, 2-SH-4-OH-6-NH2-, 2-NH2-4-Me-6-CONH2-, 2-NH2-4-Me-6-CN-; also the 4-NH2-5-Ph-*, 2,4-(OH)2-5-NO2-, 4,6-(NH2)2-5-Br-, 2-Me-4,6-(OMe)2-5-NO2-, 2-Me-4,6-(OMe)2-5-NH2-, 2-SEt-4-OH-5-Et-6-Me-, 1,4-Me2-2-SMe-6-O-, 1,3-Me2-2,4-O2-, 2-NH2-3-Et-4-Me-6-O-, and 1-Et-2-NH2-4-Me-6-O- pyrimidine derivatives In the OH and NH2 pyrimidines with or without other substituents around the ring, the main regions connected with the possibility of tautomerism are at 6 μ and 3 μ. Since ambiguities occur in both these regions, exact frequency assignments are difficult to make. The spectra are highly characteristic with sharp bands and might be used for analysis and identification. The spectral evidence suggests a ketonic structure for simple 2-OH and 4-OH derivatives and probably a diketonic form for 2,4-(OH)2 derivatives In 4,6-dihydroxypyrimidine one CO and one OH group may be present. NH2-substituents are probably not tautomerized and have the character of an amido group. The electronic effects of different substituents may influence the tautomerism and the amount of H-bonding. These conclusions do not agree in some respects with those of Brownlie (C.A. 45, 2778d).

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Name: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Reaction of oxide radical ion (O·-) with substituted pyrimidines, published in 2002-06-30, which mentions a compound: 1194-22-5, mainly applied to reaction oxide radical substituted pyrimidine oxidizing radical electron transfer; pulse radiolysis reaction oxide radical substituted pyrimidine, Formula: C5H6N2O2.

Pulse radiolysis technique has been used to investigate the reaction of oxide radical ion (O·-) with 4,6-dihydroxy-2-Me pyrimidine (DHMP), 2,4-dimethyl-6-hydroxy pyrimidine (DMHP), 5,6-di-Me uracil (DMU) and 6-Me uracil (MU) in strongly alk. medium. The second-order rate constants for the reaction of O·- with these compounds are in the range 2-5 × 108 dm3 mol-1 s-1. The transient absorption spectra obtained with DHMP have two maxima at 290 and 370 nm and with DMHP have maxima at 310 and 470 nm. The transient spectrum from DMU is characterized by its absorption maxima at 310 and 520 nm and that of MU by its single maximum at 425 nm. The intermediate species were found to react with N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD) with high G(TMPD·+) values ranged between 3.9 × 10-7 mol J-1 and 4.8 × 10-7 mol J-1. These radicals undergo decay by second-order kinetics (2k/ε = 1.0-1.7 × 106 s-1). The reaction of O·- with the selected pyrimidines is proposed to proceed through a hydrogen abstraction from the Me group forming allyl type radicals. These are mainly oxidizing radicals and hence readily undergo electron transfer reactions with TMPD.

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Formula: C5H6N2O2, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives, the main research direction is nitroacetaminophen derivative regioselective synthesis green chem; acetaminophen hydroxyphenylacetamide hydroxyphenylpiperazinylethanone electrochem oxidation nitrite ion.Product Details of 67914-60-7.

A regioselective green synthesis of nitroacetaminophen derivatives e. g., I, was carried out by electrochem. oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochem. method for the synthesis of some nitroacetaminophen derivatives

There is still a lot of research devoted to this compound(SMILES：CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O)Product Details of 67914-60-7, and with the development of science, more effects of this compound(67914-60-7) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Calzaferri, Francesco; Narros-Fernandez, Paloma; de Pascual, Ricardo; de Diego, Antonio M. G.; Nicke, Annette; Egea, Javier; Garcia, Antonio G.; de los Rios, Cristobal researched the compound: 2,6-Dichloropurine( cas:5451-40-1 ).COA of Formula: C5H2Cl2N4.They published the article 《Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation》 about this compound( cas:5451-40-1 ) in Journal of Medicinal Chemistry. Keywords: purine preparation antiinflammatory activity mol docking pharmacokinetic study; xanthine preparation antiinflammatory activity mol docking pharmacokinetic study. We’ll tell you more about this compound (cas:5451-40-1).

In this work, novel blood-brain barrier (BBB)-permeable derivatives, e.g., I as potential P2X7 antagonists were designed and synthesized. They comprise purine or xanthine cores linked to an aryl group through different short spacers. Compounds were tested in YO-PRO-1 uptake assays and intracellular calcium dynamics in a human P2X7-expressing HEK293 cell line, two-electrode voltage-clamp in Xenopus laevis oocytes, and in interleukin 1β release assays in mouse peritoneal macrophages. BBB permeability was assessed by parallel artificial membrane permeability assays and P-glycoprotein ATPase activity. Dichloroarylpurinylethanones featured a certain P2X7 blockade, being compound (2-(6-chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)ethan-1-one) (I), named ITH15004, the most potent, selective, and BBB-permeable antagonist. Compound I can be considered as a first non-nucleotide purine hit for future drug optimizations.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Cupric bromide(SMILESS: [Cu+2].[Br-].[Br-],cas:7789-45-9) is researched.Formula: C14H11N3O2. The article 《Improving Hemocompatibility: How Can Smart Surfaces Direct Blood To Fight against Thrombi》 in relation to this compound, is published in ACS Applied Materials & Interfaces. Let’s take a look at the latest research on this compound (cas:7789-45-9).

Nature utilizes endothelium as a blood interface that perfectly controls hemostasis, preventing the uncontrolled formation of thrombi. The management of pos. and neg. feedback that finely tunes thrombosis and fibrinolysis is essential for human life, especially for patients who undergo extracorporeal circulation (ECC) after a severe respiratory or cardiac failure. The exposure of blood to a surface different from healthy endothelium inevitably initiates coagulation, drastically increasing the mortality rate by thromboembolic complications. In the present study, an ultrathin antifouling fibrinolytic coating capable of disintegrating thrombi in a self-regulated manner is reported. The coating system is composed of a polymer brush layer that can prevent any unspecific interaction with blood. The brushes are functionalized with a tissue plasminogen activator (tPA) to establish localized fibrinolysis that solely and exclusively is active when it is required. This interactive switching between the dormant and active state is realized through an amplification mechanism that increases (pos. feedback) or restores (neg. feedback) the activity of tPA depending on whether a thrombus is detected and captured or not. Thus, only a low surface d. of tPA is necessary to lyse real thrombi. Our work demonstrates the first report of a coating that self-regulates its fibrinolytic activity depending on the conditions of blood.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem