Properties and Exciting Facts About (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one

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875444-08-9, Name is (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Computed Properties of C12H9F6NO2In an article, once mentioned the new application about 875444-08-9.

Type (I) method for the preparation of compounds, which comprises: 1) by 2-chloro-5-trifluoromethyl-aniline (II) with (4-fluoro-5-isopropyl-2-methoxyphenyl) borate reaction (III), to obtain 2 – (4-fluoro-5-isopropyl-2-methoxyphenyl) – 5-trifluoromethyl-aniline (formula IV); 2) with the compound represented by formula (IV) tert-butyl nitrite, reaction of acetaldehyde and alkali, to obtain 2 – (4-fluoro-5-isopropyl-2-methoxyphenyl) – 5-trifluoromethyl-benzyl alcohol by (formula V); 3) represented by formula (V) compound is reacted with halogenated reagent, then added in the reaction mixture (4S, 5R) – 5 – [3,5-bis (trifluoromethyl) phenyl] – 4-methyl -1,3-oxazolidine-2-one (VI) for the reaction, obtains the type (I) of (4S, 5R) – 5 – [3,5-bis (trifluoromethyl) phenyl] – 3 – {[ 4 the […] -fluoro -5 the […] -isopropyl -2 the […] -methoxy-4 – (trifluoromethyl) biphenyl-2-yl] methyl} – 4-methyl -1,3-oxazolidine-2-one (in other words ansai qu Pi ). (by machine translation)

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2769NO – PubChem