Chemistry is an experimental science, Category: oxazolidines, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, belongs to oxazolidines compound. In a document, author is Sundermann, Tom.
Convergent and enantioselective syntheses of cytosolic phospholipase A(2)alpha inhibiting N-(1-indazol-1-ylpropan-2-yl) carbamates
Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is an important enzyme of the inflammation cascade. Therefore, inhibitors of cPLA(2)alpha are assumed to be promising drug candidates for the treatment of inflammatory disorders. Recently we have found that indole-5-carboxylic acid with a 3-(4-octylphenoxy)-2-(phenoxycarbonylamino) propyl substituent in position 1 is an inhibitor of cPLA(2)alpha. We have now synthesized a corresponding derivative with the indole heterocycle replaced by an indazole (4) employing an analogous reaction sequence as for the synthesis of the indole derivative. Besides, a more convergent synthesis for 4 was established using an aziridine as central intermediate. Furthermore, a chiral-pool based enantioselective synthesis was developed for the synthesis of (R)- and (S)-4. Starting compound for both enantiomers was the (R)-serine derived oxazolidine (R)-25. Compound 4 proved to be a moderate inhibitor of cPLA(2)alpha, with the S-enantiomer being twice as active as the R-enantiomer. The racemate 4 and the enantiomers (R)-and (S)-4 showed a high in vitro metabolic stability in rat liver S9 fractions.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Category: oxazolidines.
Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem