With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9
To a screw-cap vial containing 3-aminooxazolidin-2-one (0.05 g) suspended in CH2CI2 (12 mL) cooled to 0 C. Then triethylamine (0.14 mL) was introduced followed by 2-fluoro-4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]benzoyl chloride (0.15 g) in one portion. The reaction contents were then poured into a separatory funnel and diluted with CH2CI2 and water. The organic layer was separated and thenwashed with 1 N HCI, 1 N NaOH, and brine. The solvent was removed under reduced pressure and the crude residue was purified by flash chromatography over silica gel (heptane:ethyl acetate gradient) togive the title compound as a white solid (mp: 186- 189C). 1H NMR (400 MHz, CDCI3): oe 8.60 (d, 1H),8.32 (d, 1H), 8.10 (d, 1H), 7.97 (d, 1H), 4.55 (t, 2H), 4.00 (t, 2H). LC/MS retention time = 0.85 minutes,361 (M+H)
80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; STIERLI, Daniel; HOFFMAN, Thomas, James; BOU HAMDAN, Farhan; (82 pag.)WO2017/157962; (2017); A1;,
Oxazolidine – Wikipedia
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