Tag: 139009-66-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.

Step (iii) :TEA (53.4 ml, 0.383 mol) at 20 C. and then a solution of T3P in DCM (154 g, 0.242 mol) are run into a medium comprising DCM (500 ml), the (Z)-amino compound in hydrochloride form (50 g, 0.142 mol) and the doubly protected L-serine of formula (II) with PG=BOC (L-serine-N-BOC-acetonide ; 41.8 g, 0.170 mol). The medium is brought to reflux and then water (500 ml) is added. After separation by settling out and concentration, the methanolic hydrochloric acid (189.5 ml, 1.136 mol) and methanol (189.5 ml) are added. Water (300 ml) is added to the medium and the phases are then separated by settling out. Isopropyl acetate (650 ml) is added to the aqueous phase and then sodium hydroxide (115 ml, 1.150 mol) is run in at 20 C. The organic phase which has been separated by settling out and washed is concentrated under vacuum and then heated to 65 C. Methanol (35 ml) and then methanolic hydrochloric acid (47.4 ml, 0.142 mol) are added at this temperature. After cooling, and filtration, the product is isolated (49.6 g, 79.5%). The final product has a purity of 99.2%.

139009-66-8, 139009-66-8 (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid 6932187, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; SANOFI-AVENTIS; US2011/124899; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

139009-66-8, (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution ofcarboxylic acid (1 mmol), EDC (1.1 mmol) and HOBT (1.1 mmol) in CH2Cl2(20 mL) was stirred at room temperature the starting material disappeared. The reaction was monitored by TLC. Thesolvent was eliminated under reduced pressure, and the residue wasco-distilled three times with dry toluene to obtain benzotriazoleesters I and II. These compounds were dissolved in anhydrousTHF (5 mL) and stored under argon before the next reaction. Completelyanhydrous conditions were crucial for attaining good yields.

139009-66-8, The synthetic route of 139009-66-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Morales-Serna, Jose Antonio; Sauza, Alejandro; Padron De Jesus, Gabriela; Gavino, Ruben; Garcia De La Mora, Gustavo; Cardenas, Jorge; Tetrahedron Letters; vol. 54; 52; (2013); p. 7111 – 7114;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem