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Quantitative online NMR spectroscopy was used for studying the species distribution in solutions of carbon dioxide in aqueous monoethanolamine (MEA) and diethanolamine (DEA). The mass fraction of the amine in the unloaded solution was 0.2 and 0.3 g/g, respectively, the carbon dioxide loading was up to 1.1 mo lC O2 / mo lamine, temperatures were between 293 and 353 K. A special apparatus was designed that allows preparing the mixtures gravimetrically and applying pressures up to 25 bar to keep the carbon dioxide in solution. It was coupled to a 400 MHz NMR spectrometer by heated capillaries. By using both 1H and 13C NMR spectroscopy quantitative information on the concentrations of the following species were obtained: amine, carbamate, bicarbonate, and carbon dioxide. Due to the fast proton transfer between molecular and protonated amine, only the sum of their concentrations can be determined. Furthermore, a byproduct, 2-oxazolidone, was observed and quantified. The experimental data were used for developing a thermodynamic model of the studied electrolyte solutions based on the extended Pitzer GE-model. In the model development, also vapor-liquid equilibrium data from the literature were included. The model gives reliable results both for the species distribution and the vapor-liquid equilibrium of the studied mixtures.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H353NO – PubChem

 

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A highly efficient copper(i)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with benzo[b]thiophene 1,1-dioxides as the dipolarophiles was developed, providing elegant access to novel chiral tricyclic pyrrolidine-fused benzo[b]thiophene 1,1-dioxide derivatives in good to excellent yields (up to 99%) with excellent diastereo- and enantioselectivities (up to >25:1 dr, up to 99% ee). Furthermore, the cycloadducts could be conveniently converted to synthetically important tricyclic pyrrolidine-fused benzo[b]thiophene and tetracyclic oxazolidin-2-one derivatives via simple transformations.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H483NO – PubChem

 

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A study was conducted to evaluate the mechanical properties of low density fiberboard produced with combinations of two fibers soybean straw (Glycine max), and wheat straw (Triticum aestivum) and two resins methylene diphenyl diisocyanate (MDI) and epoxidized sucrose soyate (ESS) resin as binders. ESS is a high performance, soybean oil based epoxy that has shown promise as a highly biobased adhesive. Six formulations of panels were produced using various combinations of straw and resin binder. Mechanical testing of sample boards was conducted using ASTM standard D1037-12. Test results showed that type of resin did not influence soy straw or wheat straw board’s stiffness and strength properties but had a major impact on water resistance, screw withdrawal strength and internal bond strength. The study demonstrated the potential of ESS as a novel binder for fiberboard system if a suitable crosslinker and catalyst is utilized. It also showed that increasing ESS content over 50% in a MDI blend lowered the performance characteristics of boards. However, analytical testing of the resin systems showed limited reactivity between ESS soyate and MDI, indicating other compatible resin chemistries should be explored for achieving superior board properties. Overall, a resin blend with 25?50% ESS in MDI appears favorable for low density fiberboards. ESS can be a promising bio-based resin as it has the potential to meet California Air and Resources Board (CARB) standards while providing acceptable properties as an adhesive.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1009NO – PubChem

 

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Trimethylsylil trichloroacetate (1) is a convenient reagent for the silylation of phenols, carboxylic acids, mercaptans, amides, acetylenes, and beta-keto esters, while the reaction of 1 with aldehydes and ketones affords silylated trichloromethyl carbinols (5).

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Oxazolidine – Wikipedia,
Oxazolidine | C3H930NO – PubChem

 

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The chemical reactivity of radical cations derived from N,O-ketene acetals has been examined and compared with the reactivity of radical cations derived from both ketene dithioacetals and enol ethers. Synthetically, the N,O-ketene acetal radical cations lead to more efficient cyclization reactions than either the ketene dithioacetal or enol ether derived radical cations. Cyclic voltammetry experiments using allylsilane trapping groups show that the efficiency of these cyclizations is not due to the N,O-ketene acetal radical cations being more reactive but rather more stable to decomposition. Finally, cyclizations using chiral oxizolidinones were examined.

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Oxazolidine – Wikipedia,
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A 1,5-naphthyridine derivative represented by Formula [1] (in which R1, R2, R3, R4 and R5 represent a hydrogen atom, -L-Z (in which Z represents a non-aromatic heterocyclic group or the like; and L represents a single bond or the like), or the like, R6 represents -L-Z or the like, R7 and R8 represent a hydrogen atom or the like, and Q represents an oxygen atom or the like), or a salt thereof has an excellent inhibitory activity with respect to the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway, and is useful for treatments such as prophylactic treatments and therapeutic treatments of diseases in which the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway are involved.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H99NO – PubChem

 

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A new bifunctional fluorescent label, BRos, was synthesised in order to monitor protein dynamics using fluorescence microscopy, and the photophysical properties were compared with those of bifunctionalised rhodamine, BRho. In a labelling experiment with a model peptide of troponin C, which regulates muscle contraction and relaxation, it was found that BRos was bound to the peptide through two linkages and provided a homogeneous compound, whereas BRho gave a pair of diastereomers having different physical properties in NMR and HPLC analyses. This journal is The Royal Society of Chemistry.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H610NO – PubChem

 

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Compounds represented by the general formula (I): wherein each symbol is as defined in the description [with the proviso that 9-chloro-7-(1,1-dimethylethyl)-2,3,4,5-tetrahydro-1,4-benz-oxazepine and N-[[(5S)-2-oxo-3-(2,3,4,5-tetrahydro-1,4-benz-oxazepin-7-yl)-5-oxazolidinyl]methyl]acetamide are excluded], salts of the same, and prodrugs thereof have selective activation effect on serotonin 5-HT2C receptor and are useful as preventive and therapeutic agents for lower urinary tract diseases, obesity, and/or pelvic organ prolapse.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H221NO – PubChem

 

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Asymmetric alkylation reactions using non-cross-linked polystyrene-supported 2-imidazolidinone chiral auxiliary derived from L-phenyl alanine

The non-cross-linked polystyrene (NCPS)-supported 2-imidazolidinone chiral auxiliary, based on a new anchoring strategy, afforded excellent diastereocontrol and yield in asymmetric alkylation reactions. The cleavage of this soluble, polymer-supported chiral auxiliary 8 produced highly optical pure carboxylic acids and strong polymer recovery.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H676NO – PubChem

 

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Synthetic stitching with silicon: Geminal alkylation-hydroxylation of alkynyl carbonyl compounds

A new strategy for the synthesis of beta-carbonyl-substituted tertiary alcohols from alpha,beta-alkynyl ketones and esters has been demonstrated. A silicon tether is used to internally deliver an alkyl group, which, combined with a C-Si to C-O transformation, can regio- and diastereoselectively “stitch” together geminal C-C and C-O bonds at the beta-position of an electron-withdrawing group. Regioselective alkyne hydrosilylation by a trans addition process provides clean access to trisubstituted vinylsilanes. Subsequent one-pot fluoride-induced C-C bond formation and oxidation of the resulting tertiary silane, a type of silane not normally reactive to such conditions, affords the desired products. The utility of neighboring ketone and carboxylate groups in promoting the oxidation of these highly hindered tertiary alcohols, an observation that may affect synthetic design of routes depending on such oxidations, is demonstrated. Good diastereoselection (>10:1) is observed for substrates bearing gamma-alkoxy stereocenters. Copyright

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1071NO – PubChem