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Copper-catalyzed intermolecular dehydrogenative amidation/amination of quinoline N-oxides with lactams/cyclamines

C-H, N-H dehydrogenative coupling of quinoline N-oxides with lactams/cyclamines has been achieved in the presence of the Cu(OAc)2 catalyst to give good to excellent yields. This study provides a new strategy for the construction of a 2-aminoquinoline skeleton via direct functionalization of aryl C-H bonds.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H736NO – PubChem

 

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Application of 497-25-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Article£¬once mentioned of 497-25-6

Role of aqueous methyldiethanolamine (MDEA) as solvent in natural gas sweetening unit and process contaminants with probable reaction pathway

Aqueous methyldiethanolamine (MDEA) is used as a solvent in natural gas sweetening unit, whose quality deteriorates while absorbing H2S/CO2 causing corrosion and foaming in the process. Total process contaminants of lean MDEA obtained from GASCO Company (Habshan, Abu Dhabi) were determined using different instruments. The major hydrocarbons found in inlet natural gas was analyzed using gas chromatography mass spectrometry (GC-MS). Heat stable salt (HSS) anions and metal ions were detected using ion chromatograph (IC) and inductively coupled plasma optical emission spectrometry (ICP-OES). Liquid chromatography mass spectrometry (LC-MS) and direct sample analysis time of flight (AxION 2TOF) analysis were carried out to determine and major organic degraded products present in lean MDEA solvent. The UV-VIS spectrophotometer also justified the presence of total organic acid anions. Acetate and propionate were found to be present in higher amounts of 2806 and 1614 ppm, respectively. Substantial amount of metal ions were also detected using ICP-OES with maximum level of heavy metal ions of lead and iron of 1.009 and 0.967 ppm, respectively. Large numbers of organic degraded products such as diethanolamine followed by methylethanolamine, N,N-bis(2-hydroxyethyl) glycine (bicine) etc. were identified using LC-MS and AxION 2TOF analyses; which are considered to be major organic thermally degraded products. Thermal degradation experiment was compared with H2S and in presence of both H2S/CO2 to obtain same compounds with varying concentration. On the basis of MDEA degradation as reported by previous researchers and from the analyzed lean MDEA samples, probable reaction pathways have been proposed.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H880NO – PubChem

 

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New progress in azole compounds as antimicrobial agents

The increasing incidence of microbial resistance and newly emerging pathogens have become a serious challenge for public health. More and more efforts have been directed to the development of new antimicrobial agents with distinct mechanisms from the well-known classes of clinical drugs. The extensive clinical utilization of azole-based medicinal drugs has evoked numerous attentions, and their researches and developments have been a quite rapid developing and active highlight topic with an infinite space. Consideration of our researches on azole compounds and other literature in recent three years, this review scientifically reviewed the new progress of azole derivatives as antibacterial, antifungal, antitubercular and antiviral agents, including mono-nitrogen azoles (oxazoles, thiazoles and carbazoles), bis-nitrogen azoles (imidazoles, pyrazoles and benzimidazoles) and tri-nitrogen azoles (triazoles and benzotriazoles) as well as tetrazole derivatives. It was hoped that this review would be helpful for the design and development of highly efficient azole derivatives with high bioactivity and low toxicity.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1196NO – PubChem

 

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Reference of 497-25-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a article£¬once mentioned of 497-25-6

Analogs of 3,4,5 trimethoxybenzamide: synthesis and effects on CNS

A series of new heterocyclic derivatives of 3,4,5 trimethoxybenzamide was synthesized and tested for C.N.S. depressant activity. The oxazolidino and imidazolino derivatives (VI c) and (VI g) were subjected to more detailed pharmacological evaluation in comparison with trimetozine, and proved to be particularly active on conditioned and aggressive behavior of rodents.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H899NO – PubChem

 

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Reference of 497-25-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 497-25-6, molcular formula is C3H5NO2, introducing its new discovery.

Diaminotetrafluoroethoxybenzenes

Tetrafluoroethoxybenzenes, and their acid addition salts, of the general formula: STR1 in which R1 may represent hydrogen or an alkyl having from 1 to 4 carbon atoms and R2, R3 and R4 represent one or more of the same or different substituents selected from hydrogen, an alkyl having 1 to 4 carbon atoms or mono- or dihydroxylalkyls having 1 to 4 carbon atoms, provided that the amino groups are situated relative to one another in an ortho- or meta- position and R1, R2, R3 and R4 do not simultaneously represent hydrogen when the amino groups are arranged in a 2,4- position. The compounds of the invention, along with 2,4-diaminotetrafluoroethoxybenzene, are useful as coupler components in oxidative hair coloring agents. A process for making the compounds, as well as a separate process for making the mono-N-beta-hydroxylethyl compounds, is provided.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H149NO – PubChem

 

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A novel and efficient (NHC)CuI (NHC = N-heterocyclic carbene) catalyst for the oxidative carbonylation of amino compounds

Oxidative carbonylation of amino compounds to prepare corresponding 2-oxazolidinones, ureas, and carbamates selectively in the presence of (NHC)CuI without any additives was firstly achieved in good yields and selectivities.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1214NO – PubChem

 

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Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones

Histone ubiquitination affects the structure and function of nucleosomes through tightly regulated dynamic reversible processes. The efficient preparation of ubiquitinated histones and their analogs is important for biochemical and biophysical studies on histone ubiquitination. Here, we report the CAACU (cysteine-aminoethylation assisted chemical ubiquitination) strategy for the efficient synthesis of ubiquitinated histone analogs. The key step in the CAACU strategy is the installation of an N-alkylated 2-bromoethylamine derivative into a recombinant histone through cysteine aminoethylation, followed by native chemical ligation assisted by Seitz’s auxiliary to produce mono- and diubiquitin (Ub) and small ubiquitin-like modifier (SUMO) modified histone analogs. This approach enables the rapid production of modified histones from recombinant proteins at about 1.5-6 mg/L expression. The thioether-containing isopeptide bonds in the products are chemically stable and bear only one atomic substitution in the structure, compared to their native counterparts. The ubiquitinated histone analogs prepared by CAACU can be readily reconstituted into nucleosomes and selectively recognized by relevant interacting proteins. The thioether-containing isopeptide bonds can also be recognized and hydrolyzed by deubiquitinases (DUBs). Cryo-electron microscopy (cryo-EM) of the nucleosome containing H2BKC34Ub indicated that the obtained CAACU histones were of good quality for structural studies. Collectively, this work exemplifies the utility of the CAACU strategy for the simple and efficient production of homogeneous ubiquitinated and SUMOylated histones for biochemical and biophysical studies.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H441NO – PubChem

 

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Method for treating glaucoma IIB

Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, 1wherein J is oxygen, sulfur, or N?Rd.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H75NO – PubChem

 

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Ag@SnO2@ZnO core-shell nanocomposites assisted solar-photocatalysis downregulates multidrug resistance in Bacillus sp.: A catalytic approach to impede antibiotic resistance

In the present study, we report the solar-photocatalytic disinfection (SPCD) of a multidrug resistant (MDR) bacterium, Bacillus sp. CBEL-1 using Ag@SnO2@ZnO core-shell nanocomposites (NCs) as catalyst. Complete disinfection was observed within 210 min with a catalyst concentration of 500 mg/L when subjected to NCs mediated PCD under solar irradiation. H2O2 was found to be the key reactive oxygen species (ROS) involved in SPCD of targeted bacteria. Increase in production of 4-HNE along with change in fatty acid profile of bacteria after SPCD induced oxidative stress indicates the compromisation of bacterial cell membrane. Irreversible change in antibiotic resistance profile of the target bacteria was notice after SPCD, without recovery even after 96 h post disinfection experiments. Traditional disinfectants and UV-250 nm were found to have marginal impact on the resistance profile of the bacteria compared to that of SPCD. Disinfection achieved using the NCs were also validated for real water samples.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H472NO – PubChem

 

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Process for producing oxazolidin-2-one derivative

An industrial process for preparing an oxazolidin-2-one derivative represented by the following general formula (3) wherein R1, R2, R3 and R4 are hydrogen atom, straight, branched or cyclic alkyl group, straight or branched alkyl group substituted by alkoxy, substituted amino or alkylthio, substituted or unsubstituted aralkyl group, or substituted or unsubstituted aryl group, and R5 is are hydrogen atom, straight, branched or cyclic alkyl group, substituted or unsubstituted aralkyl group, or substituted or unsubstituted aromatic ring,which is characterized in reacting a 1,3-dioxolan-2-one derivative and a carbamate derivative or an urea derivative in the presence of a fluoride salt.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H143NO – PubChem