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Decomposition of nitrosamines in aqueous monoethanolamine (MEA) and diethanolamine (DEA) solutions with UV-radiation

CO2 capture based on chemical absorption using amine solutions is considered to be the most feasible way to remove CO2 from low pressure sources. However, amines, when exposed to nitrous oxides, may form nitrosamines which are known to be carcinogenic. In this work the destruction of two nitrosamines, NDELA (nitrosodiethanolamine) and NDMA (nitroso-dimethylamine), with UV-light is studied in a batch reactor at room temperature and at 45C. Additionally, the effect of UV-light on the degradation of MEA is investigated.The results from this project clearly show that the rates of UV-induced decay of NDMA and NDELA are different. Additionally the efficiency of UV-light for decomposition of NDMA and NDELA depends on the type of solution. In dilute amine solutions (water wash solutions), the decay is much faster compared to more concentrated solutions. Colouring of the solutions, caused by degradation products, was found to decrease the effect of UV-light dramatically. A dynamic model for the reactor set-up used is developed and used for interpretation of the results. In all solutions the decay was found to be 1st order with respect to NDELA and NDMA concentrations.

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Oxazolidine | C3H697NO – PubChem

 

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Reactions of 5-methylene-1,3-thiazolidine-2-thione and 5-methylene-2-oxazolidinone with isocyanates catalyzed by bases

5-Methylene-1,3-thiazolidine-2-thione and 5-methylene-2-oxazolidinone can react with isocyanates to give the corresponding condensed urethanes in high yields in the presence of organic or inorganic bases under mild reaction conditions.

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Covalent modification of subtilisin Bacillus lentus Cysteine mutants with enantiomerically pure chiral auxiliaries causes remarkable changes in activity

Methanethiosulfonate reagents may be used to introduce virtually unlimited structural modifications in enzymes via reaction with the thiol group of cysteine. The covalent coupling of enantiomerically pure (R) and (S) chiral auxiliary methanethiosulfonate ligands to cysteine mutants of subtilisin Bacillus lentus induces spectacular changes in catalytic activity between diastereomeric enzymes. Amidase and esterase kinetic assays using a low substrate approximation were used to establish k(cat)/K(M) values for the chemically modified mutants, and up to 3-fold differences in activity were found between diastereomeric enzymes. Changing the length of the carbon chain linking the phenyl or benzyl oxazolidinone ligand to the mutant N62C by a methylene unit reverses which diastereomeric enzyme is more active. Similarly, changing from a phenyl to benzyl oxazolidinone ligand at S166C reverses which diastereomeric enzyme is more active. Chiral modifications at S166C and L217C give CMMs having both high esterase k(cat)/K(M)’s and high esterase to amidase ratios with large differences between diastereomeric enzymes. Copyright (C) 2000 Elsevier Science Ltd.

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Synthesis of 2-oxazolidones by sulfur-assisted thiocarboxylation with carbon monoxide and oxidative cyclization with molecular oxygen under mild conditions

Simple synthetic method on 2-oxazolidone derivatives was established. 2-Aminoethanols were easily subjected to the thiocarboxylation with carbon monoxide promoted by elemental sulfur, followed by the oxidative cyclization with molecular oxygen to give corresponding 2-oxazolidones in good yields under mild conditions (1 atm, rt). Furthermore, 2-imidazolidones and 2-thiazolidone were also prepared in good yields similarly.

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Effects of soursop (Annona muricata) leaf water extract (SLWE) on body weight, leptin and TNF alpha plasma levels of rats with high fat and high fructose (HFHF) Diet

Background: Soursop leaves believed to be able to lose weight. The aim of the study was to prove that SLWE had an effect on body weight, leptin and TNF alpha plasma level in mice with the HFHF diet. Methods: The study used post test group design only. Male Wistar rats aged 8-10 weeks weighing 175-200g, healthy, 25 were divided into 5 groups by simple random sampling. Normal groups (N), Positive groups (P) were given a HFHF 10% diet, treatment group (T1), T2, and T3 (HFHF diet + SLWE at dose of 100 mg / kg bw, 200 mg / kg bw, and 400 mg / kg bw). The diet and extract were given for 10 weeks. Measurement of body weight and weighing the amount of food consumed were carried out every week. Measurement of plasma leptin and TNF alpha levels using the ELISA method. Statistical analysis using ANOVA and Kruskal Wallis test with a confidence level p <0.05.Results: SLWE at all doses increased the amount of intake compared to P and N groups (p <0.05).Giving SLWE at dose of 400 mg/kgbw causes a slowdown in weight gain (p> 0.05), increase levels of plasma leptin than P group. There was a tendency to decrease TNF alpha plasma levels with an increase in the dose of the extract (p>0.05). Conclusion: Giving SLWE in HFHF diet-induced mice increased appetite, increased Leptin levels, and tendency to decreased weight gain and TNF alpha levels.

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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

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Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles

(Chemical Equation Presented). An effective gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions and gives the polysubstituted pyrroles in good-to-excellent yields. Preliminary results indicate that a nongold carbenoid pathway is preferred for current pyrrole synthesis.

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Photoreduction of aryl ketones by amides, lactams and various nitrogen-containing heterocycles

Benzophenone is photoreduced by amides and lactams.The hydrogen atom alpha to the nitrogen atom is abstracted regioselectively; coupling of the two resulting radicals leads to adducts with a 1-phenylethanolamide structure.The use of this general reaction in synthetic reactions is demonstrated: adducts of benzophenone with amides, lactams, 2,4-imidazolinediones, tetrahydro-2H-1,3-oxazin-2-one and 2-oxazolidinone, and of dibenzosuberone, 9H-xanthenone, 9H-thioxanthenone and alpha-tetralone with 1-methyl-2-pyrrolidinone, N,N-dimethylacetamide and N,N-diethylacetamide are described.Kinetic parameters for dibenzosuberone and 9H-thioxanthenone are given.Knowledge of the rate constants of photoreduction (kr) and autodeactivation (kTa) allows optimization of the experimental procedure to provide adducts in good yields.

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Catalytic fluoride triggers dehydrative oxazolidinone synthesis from CO2

Herein, catalytic fluoride (F-) is demonstrated to be a trigger for dehydrative immobilization of atmospheric pressure CO2, such that reaction of CO2 with beta-amino alcohols derived from natural amino acids gives optically pure oxazolidinones in high yields. A synergistic combination of fluoride and organosilicon agents (e.g., Bu4NF + Ph3SiF or siloxanes) enhances the catalytic activity and functional group compatibility. This system lies at the interface between homogenous and heterogeneous catalysis, and may prove useful for the development of recoverable/reusable siloxane-based CO2 immobilization materials. This journal is

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THIAZOLE DERIVATIVE

A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient, wherein: X1 and X2 are different from each other and represent a sulfur atom or a carbon atom; R1 represents a phenyl group; a substituted phenyl group; a phenyl group condensed with a hetero aromatic ring; a pyridyl group; or a pyridyl group condensed with a hetero aromatic ring; R2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms substituted with 1 to 5 halogen atoms, an alkoxy group having 1 to 6 carbon atoms, an alkanoyl group having 1 to 5 carbon atoms, or a hydroxyalkyl group having 1 to 6 carbon atoms, A represents a group which is represented by the formula. The present invention provides an inhibitory substance against ALK5 which is a TGF-beta type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

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