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Structures and properties of mercury(II) coordination polymers

During the last two decades, coordination polymers have received much attention and the number of synthesized compounds is still growing, which is mainly due to their potential application in such fields as microelectronics, nonlinear optics, molecular selection, ion exchange and catalysis. In contrast, coordination polymers of transition metals ions, the formation of polymers with main group metal ions such as mercury(II) is disproportionately sparse when compared with those of other metals. Because of the effects of mercury on environment and its polymers’ applications, it is necessary to understand mercury’s ability to bind donors and form complexes or coordination polymers. This review provides an overview of all the reported coordination polymers of mercury(II) after 1990 and a summary of their properties. One-dimensional polymers, constituted the majority of the mercury(II) coordination polymers and the most frequent coordination number for mercury(II) is four.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H837NO – PubChem

 

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Synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones by a one-pot Pd-catalyzed carboxamidation and aldol-type condensation cascade process

(Chemical Equation Presented) A three-component cascade process is described for the synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones by a one-pot carboxamidation/aldol-type condensation reaction. The cascade process involves Pd-catalyzed carboxamidation of an aryl halide/active methylene compound with oxazolidinone or pyrazolidinone, and subsequent intramolecular base-catalyzed cyclization/dehydration through an aldol-type condensation process, to give ring-fused oxazolo- and pyrazoloisoquinolinones. This methodology provides an easy one-step approach to these important classesof nitrogen-containing heterocycles and can tolerate a wide array of functional groups, including ester, nitrile, methoxy, and halide.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H439NO – PubChem

 

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ELECTRONIC STRUCTURE OF SOME SUBSTITUTED AZOLIDINES. CNDO/2, NMR AND VIBRATIONAL SPECTROSCOPIC STUDIES.

The 1H and 13C chemical shifts, characteristic vibrational frequencies and force constants for some substituted azolidines are correlated with the results of the CNDO/2 calculations.The influence of the exo and endo heteroatoms on the electronic structure of the heterocyclic ring are discussed.

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Oxazolidine – Wikipedia,
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Reaction of 2-{[2-(ethenyloxy)ethoxy]methyl}oxirane with oxazolidin-2-ones

Reactions of 2-{[2-(ethenyloxy)ethoxy]methyl}oxirane with N-unsubstituted oxazolidin-2-ones give mixtures of isomeric 3-{3-[2-(ethenyloxy)ethoxy]-2-hydroxypropyl}- and 5-{[2-(ethenyloxy)ethoxy]- methyl}-3-(2-hydroxyalkyl)oxazolidin-2-ones. If the initial oxazolidin-2-one contains two alkyl groups on C4, 3-{3-[2-(ethenyloxy)ethoxy]-2-hydroxypropyl}oxazolidin-2-ones are selectively formed.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H769NO – PubChem

 

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Novel synthesis of 3-aminopropionitriles by ring opening of 2-oxazolidinones with cyanide ion

Nucleophilic attack of cyanide ion on the 5-position of 2-oxazolidinones in the presence of 18-crown-6 gave 3-aminopropionitriles.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1047NO – PubChem

 

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The Use of 2-Oxazolidinone as a Latent Aziridine Equivalent. I. A Facile Method for the Preparation of 2-Substituted Oxazolines

Ring-opening reaction of 2-oxazolidinone with acid chlorides followed by treatment with aqueous sodium hydroxide yields 2-substituted oxazolines.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H906NO – PubChem

 

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The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators

The optimization of a series of benzimidazole glucokinase activators is described. We identified a novel and potent achiral benzimidazole derivative as an allosteric GK activator. This activator was designed and synthesized via removal of the chiral center of the lead compound, 6-(N-acylpyrrolidin-2-yl)benzimidazole. The activator exhibited good PK profiles in rats and dogs, and significant hypoglycemic efficacy at 1 mg/kg po dosing in a rat OGTT model. The binding site and binding mode of the benzimidazole class of GKA with GK protein was confirmed by X-ray crystallographic analysis.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1038NO – PubChem

 

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Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers

The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H165NO – PubChem

 

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Identification and characterization of chemically masked derivatives of pseudoephedrine, ephedrine, methamphetamine, and MDMA

The emergence of chemically masked illicit drugs represents a challenge to global initiatives that are working to prevent their manufacture and distribution. Targeted analytical techniques currently used by law enforcement to identify unknown materials rely on spectroscopic and spectrophotometric databases that do not currently include some of these compounds, making their identification challenging. This study aimed to update compound spectral libraries to aid in the rapid detection and identification of these masked drugs, as well as to provide insight into their synthetic procedures. Five commonly employed protecting groups, acetyl, p-tosyl, methoxycarbonyl, Fmoc, and t-Boc, were appended to pseudoephedrine, ephedrine, methamphetamine, and MDMA. Characterization was carried out using NMR, GC-MS, FTIR, high-resolution LC-MS/MS, and common screening color tests. Some of the methoxycarbonyl and t-Boc derivatives and all of the Fmoc derivatives showed partial or full thermal degradation or rearrangement during GC-MS analysis, while LC-MS/MS analysis did not always show characteristic fragmentation that would allow unambiguous assignment of the structure. Restricted rotation in some of the derivatives meant that NMR assignments could only be made using NMR spectra acquired at elevated temperature. Therefore, GC-MS and LC-MS/MS analyses serve complementary roles for these derivatives, with NMR providing confirmation of structure for the pure materials if necessary.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H803NO – PubChem

 

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Ynamide Preactivation Allows a Regio- and Stereoselective Synthesis of alpha,beta-Disubstituted Enamides

A novel ynamide preactivation strategy enables the use of otherwise incompatible reagents and allows preparation of alpha,beta-disubstituted enamides with high regio- and stereoselectivity. Mechanistic analysis reveals the intermediacy of a triflate-bound intermediate as a solution-stable, effective keteniminium reservoir, whilst still allowing subsequent addition of organometallic reagents.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H331NO – PubChem