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A NEW SYNTHESIS OF 2-OXAZOLONES

2-oxazolones were synthesized from 2-oxazolidinones utilizing anodic oxidation as the key step.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1116NO – PubChem

 

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Method for synthesizing N – styryl oxazolidine – 2 – one derivatives (by machine translation)

The invention belongs to the fine chemical product catalytic synthesis technology field, relates to a synthetic N – styryl oxazolidine – 2 – one derivatives, as follows: the oxazolidine – 2 – one, styrene compound, catalyst, polyoxometallate, additive and alkali in the organic solvent in the dehydrogenation coupling reaction, reaction finishes to obtain such as structure 1 of the structure shown in the general formula N – styryl oxazolidine – 2 – one derivatives; states the type 1 structure in the above formula, R1, R2, R3, R4, R5 are selected from the following group of any one of: hydrogen, methyl, ethoxy, tert-butyl and acetoxy. The invention has the beneficial effect that: catalyst Pd (OAc)2 Relatively cheap and easy to obtain, consumption, reaction is dehydrogenation coupling reaction, accord with the green chemistry requirement. (by machine translation)

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Oxazolidine | C3H125NO – PubChem

 

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The evolving landscape in the development of isocitrate dehydrogenase mutant inhibitors

Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of alpha -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia. After treatment with AG-221 in clinical trials, a first-in-class inhibitor of mutated IDH2, 29 patients with acute myeloid leukemia or myelodysplastic syndrome experience complete remissions and the overall response rate is 59/159 (37%). Thus, IDH mutants have become intriguing targets for cancer therapeutics. In addition to providing a brief summary of IDH mutations, this review describes known inhibitors with potential activities against IDH mutants such as AG-120, AG-221, AG-881 and AGI-6780. The evolving landscape of IDH mutant inhibitors provides us an outlook on the discovery of novel, safer, and more effective cancer treatment strategies.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H421NO – PubChem

 

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Related Products of 1192-07-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1192-07-0, Name is Isoxazolidin-3-one, molecular formula is C3H5NO2. In a article£¬once mentioned of 1192-07-0

Herbicidal isoxazolidinone derivatives

Isoxazolidinones of the following formula are herbicides: STR1 or an agriculturally acceptable salt thereof in which R1 and R2 are independently selected from -hydrogen and-halogen; and R3 is of the formula STR2 wherein n is 0 or 1, and when n is 0, W is selected from -hydrogen, -lower alkyl, -lower haloalkanoyl, and -benzoyl; X is selected from -hydrogen and -lower alkyl; and Y is selected from -hydrogen, -lower alkyl, -cycloalkyl, -lower alkanoyl, -lower haloalkanoyl, -benzoyl, -2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzoyl, -2,4-dichlorophenoxyacetyl, -lower alkyloxycarbonyl, -lower alkyloxycarbonyl, -lower alkylaminocarbonyl, -phenylaminocarbonyl, and -lower alkylthiocarbonyl; or W and X together constitute a chemical bond; and Y is selected from -nitrogen and -lower alkyloxycarbonyl; and when n is 1, X and Z together constitute a chemical bond; W is -hydrogen; V is selected from -hydrogen and -lower alkyl; and Y is selected from -lower alkyl, -phenyl, -carboxyl, and -lower alkyloxycarbonyl, or V and Y together are an alkyl chain of 4-6 carbon atoms.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1219NO – PubChem

 

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INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

The present invention comprises piperazinone-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranylprotein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.

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We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 497-25-6, and how the biochemistry of the body works.COA of Formula: C3H5NO2

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Pd-catalyzed intermolecular amidation of aryl halides: The discovery that xantphos can be trans-chelating in a palladium complex

A general method for the intermolecular coupling of aryl halides and amides using a Xantphos/ Pd catalyst is described. This system displays good functional group compatibility, and the desired C-N bond forming process proceeds in good to excellent yields with 1-4 mol % of the Pd catalyst. Additionally, the arylation of sulfonamides, oxazolidinones, and ureas is reported. The efficiency of these transformations was found to be highly dependent on reaction concentrations and catalyst loadings. A Pd complex resulting from oxidative addition of 4-bromobenzonitrile, (Xantphos)Pd(4-cyanophenyl)(Br) (II), was prepared in one step from Xantphos, Pd2(dba)3, and the aryl bromide. Complex II proved to be an active catalyst for the coupling between 4-bromobenzonitrile and benzamide. X-ray crystallographic analysis of II revealed a rare trans-chelating bisphosphine-Pd(II) structure with a large bite angle of 150.7.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1179NO – PubChem

 

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ANTI-DEPRESSANT SPIRO HEXAHYDRO ARYLQUINOLIZINE DERIVATIVES, COMPOSITION, AND METHOD OF USE THEREFOR

Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective alpha 2-adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.

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Oxazolidine – Wikipedia,
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Transition-Metal-Free One-Step Synthesis of Ynamides

A robust transition-metal-free one-step strategy for the synthesis of ynamides from sulfonamides and (Z)-1,2-dichloroalkenes or alkynyl chlorides is presented. This method is not only effective for internal ynamides but also amenable for terminal ynamides. Various functional groups, even the vinyl moiety, are compatible, and thus, this strategy offers the opportunity for further functionalization.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1191NO – PubChem

 

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An Efficient Amide-Aldehyde-Alkene Condensation: Synthesis for the N-Allyl Amides

The allylamine skeleton represents a significant class of biologically active nitrogen compounds that are found in various natural products and drugs with well-recognized pharmacological properties. In this personal account, we will briefly discuss the synthesis of allylamine skeletons. We will focus on showing a general protocol for Lewis acid-catalyzed N-allylation of electron-poor N-heterocyclic amides and sulfonamide via an amide-aldehyde-alkene condensation reaction. The substrate scope with respect to N-heterocyclic amides, aldehydes, and alkenes will be discussed. This method is also capable of preparing the Naftifine motif from N-methyl-1-naphthamide or methyl (naphthalene-1-ylmethyl)carbamate, with paraformaldehyde and styrene in a one-pot manner.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H920NO – PubChem

 

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Kinetic study of the formation reaction of N-chloro-2-oxazolidinone

The chlorination reactions of 2-oxazolidinone with hypochlorous acid (HOCl), tert-butyl hypochlorite (tBuOCl) and N-chlorosuccinimide (NCS) were studied at 25-C, constant ionic strength, and under isolation conditions. The kinetic results obtained in the formation processes of the N-chloro-2-oxazolidinone are summarized in this paper. The kinetics studied showed a first order with respect to the concentration of the each reactant and a complex dependence of the pH on the rate constant. The reactivity order with respect to the chlorinating agent found is k(HOCl)>k(tBuOCl)>k(NCS).

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H883NO – PubChem