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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Formula: C3H5NO2In an article, once mentioned the new application about 497-25-6.

The chemistry and biology of rhizoxins, novel antitumor macrolides from Rhizopus chinensis

This Report reviews completed syntheses of the potent cytotoxic fungal metabolite rhizoxin and its natural congener didesepoxyrhizoxin (rhizoxin D) along with current knowledge of the pharmacological properties of these compounds.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H614NO – PubChem

 

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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Formula: C3H5NO2In an article, once mentioned the new application about 497-25-6.

Phase-transfer catalyzed asymmetric arylacetate alkylation

Phenethyl arylacetates are alkylated under phase-transfer conditions with cinchona catalysts with alkyl halides in high yield with excellent enantioselectivity (84-99% ee) following recrystallization. Cinchonidine (CD) derived catalyst gave the (R)-product and cinchonine (CN) catalyst produced the (S)-product. The phenethyl (PE) ester group is removed, using ammonium formate and catalytic Pd/C, to give alkylated carboxylic acid products in high selectivity. The utility of the approach is demonstrated by a direct synthesis of (S)-naproxen.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H305NO – PubChem

 

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Formation of enamides via palladium(II)-catalyzed vinyl transfer from vinyl ethers to nitrogen nucleophiles

Matrix presented. Palladium(II) complexes catalyze the formation of enamides via the formal cross-coupling reaction between nitrogen nucleophiles and vinyl ethers. These vinyl transfer reactions proceed in good yields with amide, carbamate, and sulfonamide nucleophiles, and the optimal catalyst is (DPP)Pd(OCOCF3)2 (DPP = 4,7-diphenyl-1,10-phenanthroline).

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H373NO – PubChem

 

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Synthetic Route of 497-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2. In a Article£¬once mentioned of 497-25-6

Heterogeneously catalyzed selective aerobic oxidative cross-coupling of terminal alkynes and amides with simple copper(ii) hydroxide

Simple copper(ii) hydroxide Cu(OH)2 could act as an efficient heterogeneous catalyst for selective oxidative cross-coupling of a broad range of terminal alkynes and amides using air as a sole oxidant, giving the corresponding ynamides in moderate to high yields (56-93% yields). The Royal Society of Chemistry 2012.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H667NO – PubChem

 

Archives for Chemistry Experiments of Isoxazolidin-3-one

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Pyrrolizidine alkaloids: Occurrence, biology, and chemical synthesis

Covering: 2013 up to the end of 2015 This review covers the isolation and structure of new pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of pyrrolizidines as toxic components or contaminants in foods and beverages; and formal and total syntheses of naturally-occurring pyrrolizidine alkaloids and closely related non-natural analogues.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1244NO – PubChem

 

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Heat-Resistant Polymers and Composites on the Basis of Epoxy?Isocyanate Binding Agents

Abstract: The polymerization reaction of bi- and trifunctional epoxy resins with di- and polyisocyanates with different structures is studied via differential scanning calorimetry and IR spectroscopy. Polymers and composite materials (organic plastics) with high values of glass transition point, modulus of elasticity, and strength are obtained.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H518NO – PubChem

 

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1H NMR Spectroscopic Studies on the Reactions of Haloalkylamines with Bicarbonate Ions: Formation of N-Carbamates and 2-Oxazolidones in Cell Culture Media and Blood Plasma

1H NMR spectroscopic methods have been applied to compare the in vitro reactivity of the renal papillary nephrotoxin 2-bromoethanamine (BEA) with those of selected halide-substituted nephrotoxic analogues, 2-chloroethanamine (CEA), 2-fluoroethanamine (FEA), and 1-phenyl-2-iodoethanamine (PIEA). The primary 1H NMR-detectable transformation during a 24 h incubation of confluent Madin Darby canine kidney (MDCK) cells with BEA, CEA, and FEA (at concentrations up to the IC50 determined by neutral red uptake) was the appearance in cell culture media of 2-oxazolidone (OX). Additional novel signals assigned as FEA carbamate (N-carbanoyl-2-fluoroethanamine) were observed in media collected following incubation of cells with FEA. We propose that N-carbamate intermediates are formed from the spontaneous reaction of these haloalkylamines with HCO3–buffered growth media and that OX is formed from the carbamate via elimination of the hydrogen halide. Further 1H NMR experiments, conducted for up to 8 h at 25 deg C on 5 mM solutions of BEA, CEA, and FEA in (2)H2O containing a 20-fold excess of HCO3- at pH 7.6, demonstrated a time-dependent decrease in the concentration of the free haloalkylamines accompanied by the production of N-carbamate intermediates and OX. Under these pseudo-first-order reaction conditions, the formation of OX from BEA was complete within approximately 6 h. In similar reaction conditions OX formation from CEA (24 h after initiation) had reached 54 percent of its final equilibrium concentration. Equivalent experiments demonstrated that PIEA was almost completely converted to 4-phenyl-2-oxazolidinone (PHOX) within 2 h. These observations reveal the strong disposition of this series of haloalkylamines toward reaction with HCO3- and indicate that the compounds in this family may exist only transiently as free amines in vivo, where there will virtually always be excess HCO3-. The physiological relevance of the in vitro findings is further indicated by the NMR-detectable conversion of BEA to OX and also an alkylating aziridine (AZ) moiety in rat plasma containing BEA. The ability to form carbamoylated species and OX (or PHOX) may mediate the toxicity of this series of haloalkylamines and hence is potentially of considerable significance.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H307NO – PubChem

 

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Reinforced isocyanurate/oxazolidone polymers for structural composites application

A new liquid injection system suitable for molding by RIM, RTM and cast techniques is discussed. This material which is based upon an oxazolidone/urethane modified polyisocyanurate is characterized by its ultra low viscosity, low reaction exotherms and a controllable cure time, thus making it ideal for making large and complex structural parts, particularly those requiring high levels of reinforcement. Copyright 1988 Society of Automotive Engineers, Inc.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1184NO – PubChem

 

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High service temperature, self-mendable thermosets networked by isocyanurate rings

A new mending chemistry exhibiting stability at extreme temperatures and holding mechanical properties as well as mechanical stability comparable to widely used engineering plastics is reported here. This mendable thermoset polymer is synthesized using commodity reactants through the formation of an isocyanurate-oxazolidone network which exhibit a high service temperature as shown by their Tg of 270?C and Td of 365?C. We demonstrate that this network polymer is repeatedly self-mendable in the presence of a macroscopic crack, yielding considerable recovery of the polymer’s strength after thermal annealing. This self-mending behavior is derived from a high density of mechano-responsive isocyanurate rings which are introduced as cross-links in the network. After mechanically initiated cycloreversion, the recovery of isocyanurate rings in a solid state is thermally initiated. This research is the first demonstration of an isocyanurate ring as a repairing moiety. We developed a new class of intrinsic self-mendable polymers withstanding high temperatures, which will greatly impact the application of thermoset polymers in the field of structural laminates and electronics packaging.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1199NO – PubChem

 

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THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H203NO – PubChem