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Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective alpha 2-adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H25NO – PubChem

 

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The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating phytopathogenic fungi, to the use of such compounds and to seeds coated with at least one such compound. (I)

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Oxazolidine – Wikipedia,
Oxazolidine | C3H250NO – PubChem

 

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The present invention aims to provide an iminopyridine derivative compound having an alpha1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. The present invention provides a compound represented by the formula, wherein each symbol is as defined in the specification, or a salt thereof

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An efficient asymmetric approach to access functionalized pyrido- and pyrrolo[1,2-c][1,3]oxazin-1-ones has been developed through a nucleophilic addition-cyclization process of N,O-acetal with ynamides. A number of substituted ynamides 8a-8o and 3-silyloxypyrrolidine or piperidine N,O-acetals 6a, 7 were amenable to this transformation, and the desired products 9a-9o, 10a-10m were obtained with excellent regioselectivities and outstanding diastereoselectivities. Moreover, chiral ynamides 14a-14f could also experience this addition-cyclization process to afford products 15a-15f in excellent yields.

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Chemical stability of amines under CO2 capture conditions is a well known problem both for process operability and related to economy and environmental issues. Many degradation studies have been conducted under different conditions and in different apparatuses. In this work the chemical stability of a set of amines and their degradation products using 3 different setups have been studied. A new degradation compound for 2-ethanolamine (MEA), N-(2-hydroxyethyl)-2-[(2-hydroxyethyl)amino]-acetamide (HEHEAA) was quantified resulting in a total of 21 degradation compounds for MEA. Liquid phase metal and gas phase oxygen concentrations, temperature and volatility of degradation products (intermediates) all influence degradation and differences in results from the various apparatuses are observed. Conditions favouring formation of primary degradation compounds are difficult to identify and explain, but generally low metal and oxygen concentrations and temperature reduce their formation. For some of the secondary degradation compounds volatility of intermediates was an issue and higher formation rates were seen in the closed setup which preserved more of these products in the solvent compared to the open setup with gas throughput. Amines believed to form volatile degradation compounds showed lower chemical stability in the open setup compared to the closed setup. A new mechanism for the important degradation product N-(2-hydroxyethyl)-glycine (HEGly) is suggested.

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Oxazolidine | C3H1093NO – PubChem

 

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The chemoselective removal of N-1-phenylethyl group in 2-oxazolidinones by the anisole-methanesulfonic acid system was investigated. Optically active 4,5-cis- and 4,5-trans-diphenyl-2-oxazolidinones (1a-d) were easily synthesized from dl-stilbene oxides (trans- and cis-7a) using this debenzylation.

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Oxazolidine | C3H1030NO – PubChem

 

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We present here carbon-nitrogen bond formation via a coupling reaction of 2-iodo-selenophene catalyzed by Cu(I) in the presence of a base and an inexpensive ligand, and establish the first route to obtaining 2-nitrogen-selenophene derivatives in good yields. We can anticipate that this reaction works well with oxazolidinones, lactams, and aliphatic and aromatic amides, as nitrogen sources, in the absence of any supplementary additives. In addition, the reaction proceeded cleanly under mild reaction conditions and was sensitive to the ratio of amide/2-iodo-selenophene, as well as the nature of the ligand, base, and solvent.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H496NO – PubChem

 

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Isocyanurate?oxazolidone (ISOX) polymers have been reported as a novel, intrinsically self-healable thermoset, and their healing mechanism under the effect of nucleophiles, such as tertiary amines and pyridines during polymerization, is thoroughly investigated in this study. This work provides evidence that the healing behavior of the polymers results part from the transformation of isocyanurate to oxazolidone on the fracture surfaces of the ISOX polymers at elevated temperatures. The isocyanurate transformation is characterized by chemical composition of the ISOX polymers before and after a predetermined healing procedure, through a combination characterization of Fourier transform infrared spectroscopy and carbon nuclear magnetic resonance spectroscopy. From the chemical composition of the ISOX polymers, an increased oxazolidone fraction is observed after the healing event, which verifies the hypothesized healing mechanism. By correlating the change in oxazolidone fraction in the polymers during the healing event, with the corresponding healing performance of the polymers, healing efficiencies of the polymers are shown to be inversely proportional to the ratio of oxazolidone to isocyanurate in the polymers. The transformation to oxazolidone is also shown to be dependent on two variables, nucleophilicity of the polymerization catalyst and duration of the postcure. The isocyanate and epoxide polymerization mechanism in the presence of nucleophiles is also investigated to explain the effect of the catalyst nucleophilicity on the chemical composition as well as the healing performance of the ISOX polymers.

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Aza-Michael reactions of enones with carbamates took efficiently in the presence of a catalytic amount of quaternary ammonium salts and BF 3·OEt2 to afford the total products in high yields. The new catalytic system was also efficient in the aza-Michael reaction of chalcone, which was difficult to react with carbamates by transition metal salts catalysts.

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Catalytic cross double carbonylation of secondary amines and alcohols proceeds in the presence of [PdCl2(MeCN)2] and CuI under carbon monoxide (80 atm) and oxygen (5 atm). Catalytic intramolecular double carbonylation of beta-amino alcohols gives morpholine-2,3-diones, which are excellent protecting compounds of amino alcohols and important precursors for biologically active nitrogen compounds. In contrast, catalytic single carbonylation of beta-amino alcohols under a mixture (1 : 1) of carbon monoxide and oxygen (1.0 atm) proceeds to give oxazolidin-2-ones selectively. The reaction can be explained by assuming a mechanism which includes intramolecular nucleophilic attack of the hydroxy group of (hydroxyethyl)aminocarbonyl ligands on the CO ligand of the carbamoylpalladium(II) complexes, followed by reductive elimination to give morpholine-2,3-diones. In contrast, direct nucleophilic attack of the hydroxy group to the carbamoyl group affords oxazolidin-2-ones. As a common intermediate for the double and single carbonylations, carbamoylpalladium(II) complex has been isolated by the reaction of [PdCl2(PMe3)2] with beta-amino alcohol under CO. The present double carbonylation of amino alcohols provides a novel and convenient method for synthesis of alpha-oxo carboxylic acids. Thus, the morpholine-2,3-diones obtained undergo reaction with Grignard reagents chemoselectively at the ester positions to give 2-substituted 2-hydroxymorpholin-3-ones, which undergo acid hydrolysis to give alpha-oxo carboxylic acids.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H636NO – PubChem