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Cu2O/N,N?-bis(thiophen-2-ylmethyl)oxalamide is established to be an effective catalyst system for Goldberg amidation with inferior reactive (hetero)aryl chlorides, which have not been efficiently documented by Cu-catalysis to date. The reaction is well liberalized toward a variety of functionalized (hetero)aryl chlorides and a wide range of aromatic and aliphatic primary amides in good to excellent yields. Furthermore, the arylation of lactams and oxazolidinones is achieved. The present catalytic system also accomplished an intramolecular cross-coupling product.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H480NO – PubChem

 

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Bisphenol A-based vinyl ester resin (VE) was modified with acrylated epoxidised soybean and linseed oils (AESO and AELO, respectively) in 10 wt.%. The double bond/epoxy ratio in these functionalised vegetable oils was practically the same, i.e. 30/70%, allowing us to deduce effects caused by the different unsaturations in the parent oils. The crosslink density of the resins was enhanced by adding polyisocyanate. The glass transition temperature (Tg) of the hybrids was determined by differential scanning calorimetry (DSC) and dynamic mechanical thermal analysis (DMTA). Resistance to thermal degradation was assessed by thermogravimetric analysis (TGA). The fracture toughness and energy (Kc and Gc, respectively) were determined on compact tension specimens at room temperature. Incorporation of AESO and AELO reduced the Tg of VE along with slight reductions in the Kc and Gc data. The Tg reduction was less for AELO than AESO which was attributed to the higher functionality of AELO compared to AESO. Urethane crosslinking of VE (VEUH) prominently enhanced the Tg. Modification of VEUH with AES(L)O enhanced the Tg due to additional crosslinks. Urethane hybridisation was associated with a strong decrease in both Kc and Gc compared to those of the parent VE. Kc and Gc of VEUH did not change practically as a function of blending with AES(L)O. Incorporation of AES(L)O reduced the resistance to thermal degradation of both VE and VEUH.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H571NO – PubChem

 

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The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H170NO – PubChem

 

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Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H29NO – PubChem

 

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In an attempt to molecularly design liver X receptor (LXR) beta-selective agonists, we discovered that the combination of the 2-oxochromene moiety (head) and the imidazoline-2,4-dione moiety (tail) plays an important role in the expression potency and selectivity toward LXRbeta. We synthesized a series of 2-oxochromene derivatives and identified 43 as a LXRbeta-selective agonist that increased the HDL-C level without significantly elevating the TG level and resulted in a decreased lipid-accumulation area in the aortic arch in a high-fat-and-cholesterol-fed Bio F1B hamster. In this manuscript, we report the design, synthesis and pharmacology of these 2-oxochromene derivatives.

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Oxazolidine – Wikipedia,
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Compounds of the formula I STR1 in which R 1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R 2 and R 3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R 4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R 5 is hydroxyl, lower alkanoyloxy or lower alkoxycarbonyloxy, R 6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl-lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R 7 is hydrogen or lower alkyl, or R 6 and R. sub.7, together with the carbon atom with which they are bonded, are a cydoalkylidene radical and R 8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H208NO – PubChem

 

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Epoxy (EP) modified with nonpolar rubbers have the potential to achieve a concurrent improvement in mechanical and dielectric properties, when the EP-rubber interface is properly manipulated. Here we investigate rubber toughened EP based on a non-polar hydroxyl terminated polybutadiene (HTPB), and a coupling agent, dimer fatty acid diisocyanate (DDI), in which the rubber is covalently bonded to the epoxy. The mechanical and dielectric properties can be improved with the addition of HTPB and are maximized at 15 phr of elastomer inclusion. The enhanced mechanical toughness is attributed to the extensive shear yielding induced by a large amount of uniformly dispersed rubber particles; the same morphology can also combine the good insulating properties of HTPB and dielectrically favorable interfaces. These facts along with the reduced dielectric constant and loss for the modified EP suggest that the HTPB-DDI-EP can be used as a promising insulating packaging material for microelectronic applications.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H704NO – PubChem

 

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A new Michael addition/intramolecular alkylation sequence of (Z)-3-(2-bromo-3-arylacryloyl)oxazolidin-2-ones and malonates was developed. By a simple switch of the reaction conditions including the base promoter, solvent, and reaction temperature, both of the cis- and trans-isomers of a series of oxazolidinone-containing 2,3-disubstituted cyclopropane-1,1-diesters could be obtained in good-to-excellent yields and with an excellent diastereoselectivity. The utility of the cyclopropane products was demonstrated in the diastereoselective syntheses of (±)-urinaligran and a stereoisomer of (±)-virgatusin involving the AlCl3-promoted [3+2] annulation with veraldehyde or piperonal as the key step.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H979NO – PubChem

 

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A series of epoxy resin-modified polyisocyanurate (EP-PIR) foams with oxazolidone (OX) rings and isocyanurate (IS) rings have been successfully prepared by the reaction of polymethylene polyphenyl isocyanate (PAPI) and diglycidyl ether of bisphenol-A (DGEBA). Fourier transform infrared spectroscopy and differential scanning calorimetry are performed to investigate the influence of curing temperature on the chemical structure of EP-PIR foams. The results indicate that low temperature is beneficial to the formation of the IS ring, and high temperature is in favor of the OX ring. The influence of the mole ratio of [PAPI]/[DGEBA] on the mechanical properties and thermal stability has also been studied. With the increase of [PAPI]/[DGEBA], the specific compressive strength shows a maximum of 0.0135 ± 0.0003 MPa m3/kg. The optimized mole ratio of [PAPI]/[DGEBA] is around 2.5 to reach the better mechanical and thermal properties, and the glass-transition temperature is as high as 323.5C.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H422NO – PubChem

 

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A photoredox catalytic approach to synthetically valuable N-acyl-N?-aryl-N,N?-aminals is described. This method uses the addition of a radical precursor to enamides, with subsequent interception of the cationic iminium intermediate with an arylamine. The reaction has been shown to be compatible with electron-rich and electron-deficient arylamines, and moderate to good levels of diastereoselectivity can be attained using a chiral enamide. Furthermore, the N-acyl-N?-aryl-N,N?-aminal reaction products can be readily cyclized, providing a novel synthetic route to valuable gamma-lactams.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H700NO – PubChem