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What a catch! Basic ionic liquids (ILs) based on a phosphonium hydroxide derivative can be tuned for CO2 capture by varying the weak proton donors, which have different pKa values. The stability, absorption capacity, and absorption enthalpy of the ILs could be easily tuned: the best IL for CO2 capture has good stability (>300 C), energy saving (ca. 56kJ mol-1), and equimolar absorption capability. Copyright

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1107NO – PubChem

 

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Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.

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Oxazolidine – Wikipedia,
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A series of C5-substituted 1,2,4-triaryl-1H-imidazoles was synthesized. Their gene-activating properties were determined on estrogen receptor alpha positive MCF-7 breast cancer cells, stably transfected with the plasmid ERE wtcluc (MCF-7-2a cells). The influence of 4-OH and 2-Cl substituents on the phenyl rings as well as the significance of a methyl, ethyl, or phenyl group at C5 on the estrogen receptor binding and the resulting gene activation in MCF-7-2a cells was studied. The alkyl and aryl groups at C5 of 1,2,4-tris(4-hydroxyphenyl)-1H-imidazole 1 increased the transactivation, while chlorine atoms on the phenyl rings diminished this effect. 5-Ethyl-1,2,4-tris(4- hydroxyphenyl)-1H-imidazole 9 was identified as the most active compound. Its excellent transcriptional activity did not only depend on the C5 ethyl group, but also on the three hydroxyl groups of the phenyl rings. Compounds (11-14) with a reduced number of hydroxyl groups displayed distinctly lower gene activation.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1132NO – PubChem

 

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Poly(N-vinylimidazole) effectively catalyzed Michael addition of 1H-1,2,4-triazole, 3,5-dimethyl-1H-1,2,4-triazole, uracil, oxazolidin-2-one, and succinimide to but-3-en-2-one, cyclohex-2-en-1-one, methyl acrylate, and methyl vinyl sulfone in water at room temperature. The catalyst can readily be regenerated and repeatedly used at least five times without loss in activity, as shown in the reaction of 1H-1,2,4-triazole with but-3-en-2-one as an example.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H344NO – PubChem

 

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The synthesis of isocyanurate-free, linear poly(oxazolidin-2-one)s starting from diepoxides and aromatic as well as aliphatic diisocyanates is reported. N-Heterocyclic carbenes (NHCs), liberated in situ from thermally labile CO2 adducts, in combination with Lewis acids of the simplest kind (metal halides such as LiCl and MgCl2) were employed in a cooperative manner to prepare linear polymers with molecular weights (Mn) ranging from 6 to 50 kg/mol. Crucially, it is demonstrated that action of either NHC (Lewis base) or metal halide (Lewis acid) alone entails the formation of significant amounts of trimerized isocyanates (isocyanurate) and concomitant gelling of the thus cross-linked material, highlighting the advantages of a cooperative, dual catalytic approach. Reactions were conducted at 200 C with low NHC loadings (0.5 mol %) to deliver isolated yields of 60-90% within 3-8 h polymerization time. Investigations regarding regioselectivity revealed that exclusively 5-substituted oxazolidin-2-one was formed. Notably, these transformations can be catalyzed by a combination of 1,3-dimethylimidazolium-2-carboxylate, a readily accessible and robust NHC-precursor tolerant toward atmospheric conditions, and well-available LiCl. A mechanism is proposed whereby the high molecular weights and the selectivity for oxazolidinone formation over side reactions are attributed to the high nucleophilicity of the NHC, cooperative monomer activation by the metal halide, and specifically chosen reaction conditions.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H294NO – PubChem

 

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Rice beer is traditionally prepared and consumed by various ethnic populations in the Southeast Asian countries. To understand the probable effects of rice beer on human health, present research was aimed to study biochemical parameters, microbial diversity and metabolites of major rice beer varieties of Assam, namely Apong (Poro and Nogin), Xaaj and Joubishi. Alcoholic content of rice beer varieties varied from 9.41 to 19.33% (v/v). Free radical scavenging activity against DPPH· and ABTS+ were 1.94?4.14 and 1.69?3.91 mg of ascorbic acid/ml of rice beer, respectively. In relation to antioxidant activities, phenolic content varied from 2.07 to 5.40 mg gallic acid/ml of rice beer. Next-generation sequencing of 16S rDNA showed that 18 genera of bacteria were present irrespective of rice beer varieties in which lactic acid bacteria were the dominant group (90% abundance). Functional predictions based on the bacterial profiles indicated pathways, such as metabolisms of carbohydrate, amino acid, vitamins and cofactors, and xenobiotic biodegradation, to be active in the rice beer varieties. Out of 18 core bacterial genera, 7 had correlations with the predicted functions. Gas chromatography and mass spectroscopy-based metabolite analysis revealed that the metabolite profiles of the rice beer varieties consisted of 18 saccharides, 18 organic acids, 11 sugar alcohols, 8 amino acids, 1 vitamin and nutraceutical compounds thiocoumarine, carotene, oxazolidine-2-one and acetyl tyrosine. Due to the presence of potent prebiotics, probiotics and nutraceuticals, rice beer may have health benefits which need to be studied further.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H471NO – PubChem

 

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A practical and expedient synthesis of the titled compounds is described. Using the same simple procedure (DBU was reacted with the mixture of an alkynol and a nitrogen heterocycle in CH2Cl2 at rt for 16 h), a wide variety of diverse NH-containing nucleophiles such as pyrazoles, indazoles, indoles, imidazoles and benzoimidazole, oxazolidinone and benzooxazolone, triazoles, phthalimides, and N-formyl anilines, have been reacted with 4-aryl-4-hydroxy-alkynyl esters to afford good yields of desired products. This reaction proceeded by the DBU catalyzed redox isomerization of ethyl 4-aryl-4-hydroxybut-2-ynoate to (E)-ethyl 4-aryl-4-oxobut-2-enoate, followed by the DBU catalyzed aza-Michael reactions with the isomerized product in one-pot.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H589NO – PubChem

 

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The reaction of cyclic thioimidates with active methylene compounds in the presence of acetic acid anhydride was studied. In case of six- and seven-membered derivatives the reaction proceeded via substitution of thiomethoxy group affording cyclic enamines. In case of five-membered derivatives the reaction proceeded via opening of the thioimidate ring affording functionalized aminopropane derivatives.

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Oxazolidine – Wikipedia,
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A highly efficient, two-step, one-pot synthetic strategy for amides and peptides was developed by employing ynamides as novel coupling reagents under extremely mild reaction conditions. The ynamides not only are effective for simple amide and dipeptide synthesis but can also be used for peptide segment condensation. Importantly, no racemization was detected during the activation of chiral carboxylic acids. Excellent amidation selectivity toward amino groups in the presence of -OH, -SH, -CONH2, ArNH2, and the NH of indole was observed, making the protection of these functional groups unnecessary in amide and peptide synthesis.

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Studies on the alkylation of enolates derived from a range of N-acyl-5,5-dimethyloxazolidin-2-ones and N-acyl-5,5-diphenyloxazolidin-2-ones reveal that high yields and high diastereoselectivities are best obtained when homochiral 4-isopropyl-5,5-dimethyloxazolidin-2-one is employed as a chiral auxiliary.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H384NO – PubChem