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A copper-catalyzed C-N bond forming reaction among aryl siloxane and primary, secondary amines as well as amides has been described. The reaction was conducted in the presence of P(C6F5)3 and 4 A molecular sieves in CH2Cl2 at room temperature under O2. A catalytic amount of TBAF was employed to activate aryl siloxanes.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H751NO – PubChem

 

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Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH 1/2 comprising administering to a subject in need thereof a compound described here

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Oxazolidine – Wikipedia,
Oxazolidine | C3H204NO – PubChem

 

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Oxazolidinones are multifunctional compounds possessing diverse biological and pharmacological activity. Enzymatic synthesis of oxazolidin-2-one was studied using 2-aminoalochol and dimethyl carbonate and synthesis of 3-ethyl-1,3-oxazolidin-2-one was chosen as the model reaction using a variety of immobilized lipases; among which Candida antarctica lipase B (Novozyme 435) was the best catalyst. The reaction leads to the final product oxazolidin-2-one via methyl ethyl (2-hydroxyethyl) carbamate as the intermediate. The parameters affecting rate of reaction and the conversion of both steps were studied systematically and covered effects of agitation speed, solvent, catalyst loading and reaction temperature. A reaction mechanism was proposed wherein the coproduct methanol is generated in the first step leading to the formation of methyl ethyl (2-hydroxyethyl) carbamate as the intermediate which rearranges itself leading to the final products 3-ethyl-1,3-oxazolidin-2-one and methanol. The kinetic constant and activation energy were determined for each step of the reaction. The study was further extended to other 2-aminoalochols under optimized reaction conditions to prepare different oxazolidinones. This is a first report of its kind describing kinetics and mechanism of bimolecular consecutive enzyme catalyzed reactions.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1159NO – PubChem

 

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A one-pot iodo-cyclization/transition metal-catalyzed cross-coupling sequence is reported to access various C5-functionalized oxazolidin-2-ones from unsaturated N-Boc-allylamines. Depending on the Grignard reagents used for the cross-coupling, e.g., aryl- or cyclopropylmagnesium bromide, a cobalt or copper catalyst has to be used to obtain the functionalized oxazolidin-2-ones in good yields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H417NO – PubChem

 

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The present invention relates to the use of polyols of formula (I): or a salt thereof, for preventing the hair from breaking. The invention also relates to a cosmetic composition comprising at least one such polyol or a salt thereof, in a cosmetically acceptable medium, and also to a cosmetic hair treatment process using the said composition.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H65NO – PubChem

 

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In this paper, standard molar energies of combustion of 2-oxazolidinone and 3-acetyl-2-oxazolidinone are reported. The experimental values, obtained from static-bomb combustion calorimetry, are ?(1465.42 ± 0.52) kJ·mol?1 and ?(2350.86 ± 0.84) kJ·mol?1, respectively. Using these combustion energy values, the standard molar enthalpies of formation, in crystalline phase, for the aforesaid compounds were calculated. These values were also determined, and the corresponding values are ?(430.30 ± 0.96) kJ·mol?1 and ?(617.72 ± 1.58) kJ·mol?1, respectively. The standard molar enthalpies of sublimation at T = 298.15 K were experimentally obtained by using the well-known Knudsen effusion method. The obtained values are (84.20 ± 3.22) kJ·mol?1 and (82.36 ± 1.84) kJ·mol?1, respectively. From the above experimental results, the standard molar enthalpies of formation in gas-phase of the compounds were derived. The values are: ?(346.10 ± 3.36) kJ·mol?1 and ?(535.36 ± 2.43) kJ·mol?1, respectively. To support the consistency of the experimental results presented here, enthalpies of formation in gas-phase, using the G4 composite method, were carried out as well. Experimental results suggest that the formation of intermolecular hydrogen bonds between the nitrogen (at ring’s position 3, see Fig. 1) with the oxygen (at ring’s position 2, see Fig. 1) contributes to the values of temperature and enthalpy of fusion, enthalpy of sublimation, and enthalpy of formation in solid phase.

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Oxazolidine – Wikipedia,
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A number of N-phosphoryl oxazolidinones have been prepared and evaluated, the best being 5,5-diphenyl oxazolidinones, the utility of which was demonstrated in the phosphorylation of a number of representative primary, secondary, tertiary, and phenolic alcohols.

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Oxazolidine – Wikipedia,
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Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing divergent and straightforward entries to numerous building blocks such as bromoenamides, ynamides, ketene N,N-acetals, bromoenol ethers, ynol ethers, ketene O,O-acetals, or vinylphosphonates and further expanding the copper catalysis toolbox with useful and versatile processes.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H672NO – PubChem

 

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This review is an attempt to give an overview on the recent advances and developments in the synthesis of 2-oxazolidinone frameworks through carbon dioxide (CO2) fixation reactions under solvent-free conditions. The cycloaddition of CO2 to aziridine derivatives is discussed first. This is followed by carboxylative cyclization of N-propargylamines with CO2 and three-component coupling of epoxides, amines, and CO2. Finally, cycloaddition of CO2 to propargylic alcohols and amines will be covered at the end of the review. The literature has been surveyed up until the end of 2018.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H313NO – PubChem

 

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A scale of solute hydrogen-bond acidity has been constructed using equilibrium constants (as log K values) for complexation of series of acids (i) against a given base in dilute solution in tetrachloromethane, equation (A). Forty-five such equations have been solved to yield LB and DB log Ki = LB log KAHi +DB (A) values characterising the base, and log KAH values that characterise the acid. In this analysis, use has been made of the novel observation that all the lines in equation (A) intersect at a given point where log K = log KAH = -1.1 with K on the molar scale. Some 190 log KAH values that constitute a reasonably general scale of solute hydrogen-bond acidity have been obtained. It is shown that there is no general connection between log KAH and any proton-transfer quantities, although certain family dependences are obtained. A number of acid-base combinations are excluded from equation (A), and alternative log KAHE values have been determined for such cases. The general log KAH values may be transformed into alpha2H values suitable for use in multiple linear-regression analysis through the equation alpha2H = (log KAH +1 .1 )/4.636.

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Reference:
Oxazolidine – Wikipedia,
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