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Silylating agents, such as 3-alkylsilyl-2-oxazolidinones, are useful for the preparation of penicillins and cephalosporins at low temperatures and in a short time. The process for preparing these compounds comprises reacting 2-oxazolidinone or 5-methyl-2-oxazolidinone with trimethylchlorosilane, dimethylchlorosilane or triethylchlorosilane, in the presence of an organic tertiary base acting as a hydrogen chloride removal agent.

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Oxazolidine – Wikipedia,
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(Chemical Equation Presented) The yields of ynamides using Hsung’s second generation protocol depend substantially on the quality of K3PO 4. Samples of K3PO4 from different suppliers were investigated by various techniques, revealing that the use of pure and anhydrous K3PO4 provides higher ynamide yields in comparison to samples contaminated with hydrates (K3PO 4·1.5H2O and K3PO4· 7H2O). With high quality K3PO4, a number of ynamides were synthesized in yields of 52-91%. In addition, we report that ynamides can undergo regioselective hydroamination with carbamates.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H500NO – PubChem

 

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2-Oxazolidinone or N-substituted derivatives thereof are reacted with aromatic amine hydrochlorides at elevated temperatures to produce 1,2-ethanediamines.

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Oxazolidine – Wikipedia,
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Using the C2-symmetric bis-oxazoline copper(II) catalyst 6f as a chiral Lewis acid, alpha?-phosphoric enones 2 undergo 1,3-dipolar cycloaddition with nitrones 3 to provide isoxazolidines 4 with very high enantioselectivity and endo/exo selectivity.

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Oxazolidine – Wikipedia,
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2,6-Disubstituted anilines are readily prepared from the direct reaction between amides and diaryliodonium salts. As demonstrated for 24 different examples, the reaction is of unusually broad scope with respect to the sterically congested arene and the nitrogen source, occurs without the requirement for any additional promoter, and proceeds through a direct reductive elimination at the iodine(III) center. The efficiency of the coupling procedure is further demonstrated within the short synthesis of a chemerin binding inhibitor.

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Oxazolidine – Wikipedia,
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The present invention is directed to certain novel compounds represented by structural formula I: STR1 or a pharmaceutically acceptable salt thereof, wherein R 3, R 6, R 7, R 8, R 11, R 12, R 13, m, n and the dashed lines are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

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Oxazolidine – Wikipedia,
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The intermolecular diastereoselective and enantioselective synthesis of pyrrolo[1,2-a]indoles is developed through a [3+2] cycloaddition between silyl-indole derivatives and alpha,beta-unsaturated N-acyl oxazolidinones by merging photocatalysis and Lewis acid catalysis.

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Oxazolidine – Wikipedia,
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(Chemical Equation Presented) A facile route to obtain ynamides in high yields was described. The products were achieved through the iron-catalyzed C-N coupling reaction of amides with alkynyl bromides in the presence of 20 mol % of N,N?-dimethylethane-1,2-diamine (DMEDA).

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Oxazolidine – Wikipedia,
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Highly diastereoselective and enantioselective addition of N-benzylhydroxylamine to imides 17 and 20-30 produces alpha,beta-trans-disubstituted N-benzylisoxazolidinones 19 and 31-41. These reactions proceed in 60-96% ee with 93-99% de’s using 5 mol % of Mg(NTf2)2 and ligand 18. The product isoxazolidinones can be hydrogenolyzed directly to provide ?,beta-disubstituted-beta-amino acids. Copyright

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Oxazolidine – Wikipedia,
Oxazolidine | C3H996NO – PubChem

 

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Alkylative carboxylation of ynamides with CO2 and dialkylzinc reagents using a N-heterocyclic carbene (NHC)-copper catalyst has been developed. A variety of ynamides, both cyclic and acyclic, undergo this transformation under mild conditions to afford the corresponding alpha,beta-unsaturated carboxylic acids, which contain the alpha,beta-dehydroamino acid skeleton. The present alkylative carboxylation formally consists of Cu-catalyzed carbozincation of ynamides with dialkylzinc reagents with the subsequent nucleophilic carboxylation of the resulting alkenylzinc species with CO2. Dialkylzinc reagents bearing a beta-hydrogen atom such as Et2Zn and Bu2Zn still afford the alkylated products despite the potential for beta-hydride elimination. This protocol would be a desirable method for the synthesis of highly substituted alpha,beta- dehydroamino acid derivatives due to its high regio- and stereoselectivity, simple one-pot procedure, and its use of CO2 as a starting material. CO2 incorporation with alkylation: Alkylative carboxylation of ynamides with CO2 and a dialkylzinc reagent has been achieved by using a N-heterocyclic carbene (NHC)-copper complex as the catalyst. The reactions proceeded by Cu-catalyzed carbozincation of ynamides with dialkylzinc reagents and the subsequent carboxylation of the resulting alkenylzinc species (see scheme).

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Oxazolidine – Wikipedia,
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