Tag: M.W:100-200

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Convergent synthesis of 2-thioether-substituted (N)-methanocarba-adenosines as purine receptor agonists, published in 2021, which mentions a compound: 5451-40-1, mainly applied to thioether methanocarba adenosine purine receptor agonist convergent synthesis, Recommanded Product: 2,6-Dichloropurine.

A linear route has been used to prepare (N)-methanocarba-nucleoside derivatives, which serve as purine receptor ligands having a pre-established, receptor-preferred conformation. To introduce this rigid ribose substitute, a Mitsunobu reaction of a [3.1.0]bicyclohexane 5′-trityl intermediate 3 with a nucleobase is typically followed by functional group modifications. We herein report an efficient scalable convergent synthesis for 2-substituted (N)-methanocarba-adenosines, which were demonstrated to bind to the A3 adenosine receptor. The adenine moiety was pre-functionalized with 2-thioethers and other groups before coupling to the bicyclic precursor (3) as a key step to facilitate a high yield Mitsunobu product. This new approach provided the (N)-methanocarba-adenosines in moderate to good yield, which effectively increased the overall yield compared to a linear synthesis and conserved a key intermediate 3 (a product of nine sequential steps). The generality of this convergent synthesis, which is suitable as an optimized preclin. synthetic route, was demonstrated with various 2-thioether and 2-methoxy substituents.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

COA of Formula: C5H6N2O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis of some potential high energy materials using metal nitrates; an approach towards environmental benign process. Author is Saikia, Ananta; Sivabalan, Renganathan; Gore, Girish M.; Sikder, Arun K..

A novel and efficient method for the synthesis of various promising high energy materials (HEMs) like nitrotriazolone (NTO), 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), bis (2,2-dinitropropyl)nitramine (BDNPN), 1,1-diamino-2,2-dinitroethylene (FOX-7) etc. using metal nitrates/sulfuric acid as nitrating agent has been described successfully. The synthesized materials have been characterized using various spectroscopic techniques as well as thermal studies and the data obtained confirmed their structure. From the study it was revealed that this method certainly an alternative method of preparation of high energy materials (HEMs) in place of the conventional nitration mixture

Here is just a brief introduction to this compound(1194-22-5)COA of Formula: C5H6N2O2, more information about the compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one) is in the article, you can click the link below.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H2Cl2N4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about An efficient regioselective synthesis of N-alkylated purine-triazole analogues. Author is Pandit, Chintan; Pandya, Mayank; Jadeja, Yashwantsinh; Gohel, Jyoti; Kapadiy, Khushal.

Nitrogen rich purine adduct 6-chloro-2-hydrazinyl-9H-purine was prepared by reaction of 2,6-dichloro purine with hydrazine hydrate and converted to 4-chloro-8-(3-phenoxyphenyl)-1H,5aH,6H-[1,2,4]triazolo[3,4-b]purine by a simple cyclization process (con.HCl & methanol) on reaction with 3-phenoxy benzaldehyde. These studies gave an idea regarding replacement of chlorine out of C-2 or C-6 position. Novelty was introduced by alkyl substation at N-9 position of imidazole ring and at -NH of triazole ring and a series of 4-chloro-5a,6-dihydro-1,6-dialkylated-8-(3-phenoxyphenyl)-1H-[1,2,4]triazolo[3,4-e]purine I [R = CH3, (CH2)2CH3, CH(CH3)2, etc.] hybrids were synthesized.

Here is just a brief introduction to this compound(5451-40-1)Computed Properties of C5H2Cl2N4, more information about the compound(2,6-Dichloropurine) is in the article, you can click the link below.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Calzaferri, Francesco; Narros-Fernandez, Paloma; de Pascual, Ricardo; de Diego, Antonio M. G.; Nicke, Annette; Egea, Javier; Garcia, Antonio G.; de los Rios, Cristobal researched the compound: 2,6-Dichloropurine( cas:5451-40-1 ).COA of Formula: C5H2Cl2N4.They published the article 《Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation》 about this compound( cas:5451-40-1 ) in Journal of Medicinal Chemistry. Keywords: purine preparation antiinflammatory activity mol docking pharmacokinetic study; xanthine preparation antiinflammatory activity mol docking pharmacokinetic study. We’ll tell you more about this compound (cas:5451-40-1).

In this work, novel blood-brain barrier (BBB)-permeable derivatives, e.g., I as potential P2X7 antagonists were designed and synthesized. They comprise purine or xanthine cores linked to an aryl group through different short spacers. Compounds were tested in YO-PRO-1 uptake assays and intracellular calcium dynamics in a human P2X7-expressing HEK293 cell line, two-electrode voltage-clamp in Xenopus laevis oocytes, and in interleukin 1β release assays in mouse peritoneal macrophages. BBB permeability was assessed by parallel artificial membrane permeability assays and P-glycoprotein ATPase activity. Dichloroarylpurinylethanones featured a certain P2X7 blockade, being compound (2-(6-chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)ethan-1-one) (I), named ITH15004, the most potent, selective, and BBB-permeable antagonist. Compound I can be considered as a first non-nucleotide purine hit for future drug optimizations.

Here is just a brief introduction to this compound(5451-40-1)COA of Formula: C5H2Cl2N4, more information about the compound(2,6-Dichloropurine) is in the article, you can click the link below.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Series of 2-methyl-5-alkyl-4,6-dihydroxypyrimidines》. Authors are Ferris, Livingston P. II; Ronzio, Anthony R..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).SDS of cas: 1194-22-5. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Acetamidine-HCl (1/8 mol.), added to 150 cc. absolute EtOH and 3.3 g. Na, followed by 0.05 mol. of CH2(CO2Et)2 or its monoalkyl derivative, and allowed to stand 2-3 days, the solution exactly neutralized with concentrated HCl, H2O added to dissolve the NaCl, the undissolved pyrimidine filtered, decolorized in boiling AcOH and reprecipitated with Et2O, gives the following 2-methyl-5-alkyl-4,6-dihydroxypyrimidines, the group in position 5 being: H (I) (43%), Me (18%), Et (15%), Pr (22%), Bu (II) (33%) and Am (26%). These do not show definite m. ps. but sublime between 260-350°; in a sealed tube they decompose without melting. The absorption spectra curves are given for I in H2O, HCl and KOH and for II in EtOH.

Compound(1194-22-5)SDS of cas: 1194-22-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one), if you are interested, you can check out my other related articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

HPLC of Formula: 70-23-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Rearrangement in the systems ethyl bromopyruvate-1-(cyclohex-1-enyl)piperidine, -pyrrolidine, and -morpholine as an efficient approach to 4,5,6,7-tetrahydroindoles. Author is Mamedov, V. A.; Zamaletdinova, A. I.; Syakaev, V. V.; Khafizova, E. A.; Latypov, Sh. K.; Sinyashin, O. G..

1-(Cyclohex-1-enyl)piperidine, -pyrrolidine, and -morpholine reacted with Et bromopyruvate in refluxing dioxane to afford the corresponding 4,5,6,7-tetrahydroindole derivatives Possibility to convert the synthesized compounds into their aromatic counterparts was exemplified by one model compound

Compound(70-23-5)HPLC of Formula: 70-23-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Ethyl 3-bromo-2-oxopropanoate), if you are interested, you can check out my other related articles.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Formula: C5H6N2O2.Prasanthkumar, Kavanal P.; Mohan, Hari; Pramod, Gopinathan; Suresh, Cherumuttathu H.; Aravindakumar, Charuvila T. published the article 《Anomalous reaction of oxide radical ion with 5-azacytosines: An experimental and theoretical study》 about this compound( cas:1194-22-5 ) in Chemical Physics Letters. Keywords: anomalous reaction oxide radical ion azacytosine pulse radiolysis. Let’s learn more about this compound (cas:1194-22-5).

The reactions of oxide radical ion (·O-) with 5-azacytosine (5AC) and 5-azacytidine (5ACyd) in aqueous medium were studied using the pulse radiolysis technique and quantum chem. calculation using d. functional theory (DFT). It is demonstrated that the major reaction pathway is the addition of ·O- to the ring nitrogen of 5AC, followed by a fast protonation of adducts by water. Only a minor percentage (<18%) undergoes an electron transfer reaction. The similarity in the reaction mechanism of ·O- (addition to azacytosine) and ·OH (which generally participates in an addition reaction) is an interesting observation and is quite unusual in the case of heterocyclic compounds Compound(1194-22-5)Formula: C5H6N2O2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one), if you are interested, you can check out my other related articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Related Products of 70-23-5. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Cyclohexyl amide-based novel bacterial topoisomerase inhibitors with prospective GyrA-binding fragments. Author is Kolaric, Anja; Novak, Doroteja; Weiss, Matjaz; Hrast, Martina; Zdovc, Irena; Anderluh, Marko; Minovski, Nikola.

Aim: Novel bacterial topoisomerase inhibitors (NBTIs) are a promising class of bacterial topoisomerase II inhibitors that are gaining more and more importance mainly because of their excellent antibacterial activity, as well as their lack of cross-resistance to quinolones. Results: Described here is the synthesis and biol. evaluation of a tiny series of new virtually assembled NBTIs containing synthetically feasible right-hand side fragments capable of binding the GyrA subunit of the bacterial DNA gyrase-DNA complex. Conclusion: NBTI variants with incorporated 1-phenylpyrazole right-hand side moiety show suitable antibacterial activity against Gram-pos. Staphylococcus aureus, with confirmed selectivity over the human topoisomerase IIa enzyme.

Compound(70-23-5)Related Products of 70-23-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Ethyl 3-bromo-2-oxopropanoate), if you are interested, you can check out my other related articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

SDS of cas: 5451-40-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity. Author is Rouchal, Michal; Rudolfova, Jana; Krystof, Vladimir; Vojackova, Veronika; Cmelik, Richard; Vicha, Robert.

Cyclin-dependent kinases (CDKs) play an important role in the cell-division cycle. Synthetic inhibitors of CDKs are based on 2,6,9-trisubstituted purines and are developed as potential anticancer drugs; however, they have low solubility in water. In this study, authors proved that the pharmaco-chem. properties of purine-based inhibitors can be improved by appropriate substitution with the adamantane moiety. Authors prepared ten new purine derivatives with adamantane skeletons that were linked at position 6 using phenylene spacers of variable geometry and polarity. Authors demonstrated that the adamantane skeleton does not compromise the biol. activity, and some of the new purines displayed even higher inhibition activity towards CDK2/cyclin E than the parental compounds These findings were supported by a docking study, which showed an adamantane scaffold inside the binding pocket participating in the complex stabilization with non-polar interactions. In addition, authors demonstrated that β-cyclodextrin (CD) increases the drug’s solubility in water, although this is at the cost of reducing the biochem. and cellular effect. Most likely, the drug concentration, which is necessary for target engagement, was decreased by competitive drug binding within the complex with β-CD.

Compound(5451-40-1)SDS of cas: 5451-40-1 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,6-Dichloropurine), if you are interested, you can check out my other related articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic Chemistry called Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors, Author is Chen, Dizhong; Soh, Chang Kai; Goh, Wei Huang; Wang, Zilong; Wang, Haishan, which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, Formula: C5H2Cl2N4.

A series of 6-phenylpurine based hydroxamates I (R = morpholin-4-yl, diethylaminyl, dimethylaminyl, pyrrolidin-1-yl; R1 = Et, iso-Pr, Pr, cyclopentyl, pentan-3-yl; R2 = 3-[(hydroxycarbamoyl)methyl]oxidanyl, 4-[4-(hydroxycarbamoyl)butoxy]methyl, 3-[4-(hydroxycarbamoyl)piperidin-1-yl]methyl, etc.) have been designed, synthesized and evaluated. Compound I (R = morpholin-4-yl; R1 = isopropyl; R2 = 3-[3-(hydroxycarbamoyl)propyl]oxidanyl (A)) and its analogs are potent histone deacetylase (HDAC) but weak PI3K/mTOR inhibitors. These compounds demonstrated broad anti-cancer activities against 38 cancer cell lines with leukemia, lymphoma, and the majority of liver cancer cell lines exhibiting the most sensitivity towards these compounds Compound (A) demonstrated modulation of HDAC targets in vitro in a dose-dependent manner. It has good in vitro ADME profile that translated into a greatly improved pharmacokinetic profile., the compound (A) also demonstrated modulation of HDACs in tumors in a PC-3 xenograft model. It was further evaluated in combination therapies in vitro. It exhibited additive or synergistic growth inhibition effect in HepG2 cells when combined with a number of approved drugs such as sorafenib, sunitinib, and erlotinib. Hence, compound (A) has the potential to be combined with the above to treat advanced liver cancer. As such, current data warrant further evaluation, optimization, and subsequent in vivo validation of the potential combination therapies.

Compound(5451-40-1)Formula: C5H2Cl2N4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,6-Dichloropurine), if you are interested, you can check out my other related articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem