Tag: M.W:100-200

Name: 2,6-Dichloropurine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer. Author is Yun, Fan; Cheng, Chunhui; Ullah, Sadeeq; Yuan, Qipeng.

Designe and synthesis of series of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent kinase2 (CDK2) dual inhibitors by integrating purine-based pharmacophore into the recognition cap group of CS055. The representative compound e.g., I [R1 = 4-MeC6H4] with excellent antiproliferative activities towards five solid cancer cells, showed potent inhibitory activities against HDAC1, HDAC2 and CDK2 with IC50 values of 70.7 nM, 23.1 nM and 0.80μM, resp. Besides, compound I could effectively block the cell cycle in the G2/M phase and induce apoptosis, which might be related to increasing intracellular ROS levels. Importantly, compound I exhibited desirable pharmacokinetic (PK) properties with the i.p. bioavailability of 50.8% in ICR mice, and potent in vivo antitumor activity in the HCT116 xenograft model. Therefore, compound I could be considered as a promising lead compound for the development of multitargeting anticancer agents.

When you point to this article, it is believed that you are also very interested in this compound(5451-40-1)Name: 2,6-Dichloropurine and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Li, Bing; Shang, Xiaodong; Li, Linlin; Xu, Yuankang; Wang, Hanyu; Yang, Xiaofeng; Pei, Meishan; Zhang, Ruiqing; Zhang, Guangyou published an article about the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5,SMILESS:O=C(OCC)C(CBr)=O ).SDS of cas: 70-23-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70-23-5) through the article.

A new fluorescence probe, (E)-N’-(2-hydroxybenzylidene)-6-phenylimidazo[2,1-b]thiazole-3-carbohydrazide (LB1), based on 6-phenylimidazo[2,1-b]thiazole and salicylaldehyde was designed and synthesized. The chem. structures of LB1 and its intermediate were characterized via 1H NMR, 13C NMR, FTIR, and mass spectrometry. The LB1 probe exhibited high sensitivity and selectivity towards In3+ and Cr3+via a fluorescence ‘off-on-off’ response. The detection limits of In3+ and Cr3+ were 2.59 × 10-9 M and 8.05 × 10-7 M, resp. The LB1 probe demonstrated ideal selectivity for In3+ among other competing ions and the newly formed complex [LB1 + In3+] could be further used as a new fluorescence platform towards Cr3+. The Job Plot of LB1 towards In3+ and Cr3+ was 1:1 and this was supported by mass spectrometry. The plausible binding modes and mechanisms were determined through DFT/TDDFT calculations using Gaussian 09.

When you point to this article, it is believed that you are also very interested in this compound(70-23-5)SDS of cas: 70-23-5 and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70-23-5, is researched, Molecular C5H7BrO3, about Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specific inhibitors, the main research direction is benzoimidazoimidazole preparation TRPM2 channel inhibitor; 2-APB; Inhibitors; SAR; Transient receptor potential melastatin 2 (TRPM2) channel; benzo[d]imidazo[1,2-a]imidazole.Quality Control of Ethyl 3-bromo-2-oxopropanoate.

Transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer and neurodegenerative diseases. However, the lack of specific inhibitors impedes the development of TRPM2 targeted therapeutic agents. To develop a selective TRPM2 inhibitor, three-dimensional similarity-based screening strategy was employed using the energy-minimized conformation of non-selective TRPM2 inhibitor 2-APB as the query structure, which resulted in the discovery of a novel tricyclic TRPM2 inhibitor I with benzo[d]imidazo[1,2-a]imidazole skeleton. A series of I derivatives were subsequently synthesized and evaluated using calcium imaging and electrophysiol. approaches. Among them, preferred compounds II and III inhibited the TRPM2 channel with micromolar half-maximal inhibitory concentration values and exhibited TRPM2 selectivity over the TRPM8 channel, TRPV1 channel, InsP3 receptor and Orai channel. The anal. of structure-activity relationship provides valuable insights for further development of selective TRPM2 inhibitors. Neuroprotection assay showed that II and III could effectively reduce the mortality of SH-SY5Y cells induced by H2O2. These findings enrich the structure types of existing TRPM2 inhibitors and might provide a new tool for the study of TRPM2 function in Reactive oxygen species (ROS) -related diseases.

When you point to this article, it is believed that you are also very interested in this compound(70-23-5)Quality Control of Ethyl 3-bromo-2-oxopropanoate and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 70-23-5. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis, spectroscopic, SC-XRD characterizations and DFT based studies of ethyl 2-(substituted-(2-benzylidenehydrazinyl))thiazole-4-carboxylate derivatives. Author is Haroon, Muhammad; Khalid, Muhammad; Akhtar, Tashfeen; Tahir, Muhammad Nawaz; Khan, Muhammad Usman; Saleem, Muhammad; Jawaria, Rifat.

Two (arylmethylenehydrazinyl)thiazolecarboxylates were prepared; their structures were determined by X-ray crystallog. The bond vibrations and UV/visible absorptions were determined for the (arylmethylenehydrazinyl)thiazolecarboxylates; the HOMO and LUMO orbitals, electrophilicity, electron affinity, ionization potentials, electronegativities, and first- and second-order hyperpolarizabilities were determined computationally.

When you point to this article, it is believed that you are also very interested in this compound(70-23-5)Recommanded Product: 70-23-5 and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,6-Dichloropurine( cas:5451-40-1 ) is researched.Safety of 2,6-Dichloropurine.Bhattarai, Sanjay; Pippel, Jan; Meyer, Anne; Freundlieb, Marianne; Schmies, Constanze; Abdelrahman, Aliaa; Fiene, Amelie; Lee, Sang-Yong; Zimmermann, Herbert; El-Tayeb, Ali; Yegutkin, Gennady G.; Straeter, Norbert; Mueller, Christa E. published the article 《X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy》 about this compound( cas:5451-40-1 ) in Advanced Therapeutics (Weinheim, Germany). Keywords: mammary gland neoplasm CD73 cancer immunotherapy. Let’s learn more about this compound (cas:5451-40-1).

Ecto-5-nucleotidase (CD73, EC 3.1.3.5) catalyzes the extracellular hydrolysis of AMP yielding adenosine, which induces immunosuppression, angiogenesis, metastasis, and proliferation of cancer cells. CD73 inhibition is therefore proposed as a novel strategy for cancer (immuno)therapy, and CD73 antibodies are currently undergoing clin. trials. Despite considerable efforts, the development of small mol. CD73 inhibitors has met with limited success. To develop a suitable drug candidate, a high resolution (2.05 Å) co-crystal structure of the CD73 inhibitor PSB-12379, a nucleotide analog, in complex with human CD73 is determined This allows the rational design and development of a novel inhibitor (PSB-12489) with subnanomolar inhibitory potency toward human and rat CD73, high selectivity, as well as high metabolic stability. A co-crystal structure of PSB-12489 with CD73 (1.85 Å) reveals the interactions responsible for increased potency. PSB-12489 is the most potent CD73 inhibitor to date representing a powerful tool compound and novel lead structure.

When you point to this article, it is believed that you are also very interested in this compound(5451-40-1)Safety of 2,6-Dichloropurine and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

COA of Formula: C5H6N2O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about 1,1-Diamino-2,2-dinitroethylenes are always zwitterions. Author is Gilinsky-Sharon, Pessia; Gottlieb, Hugo E.; Rajsfus, David E.; Keinan-Adamsky, Keren; Marks, Vered; Aped, Pinchas; Frimer, Aryeh A..

The nitration of tetraiodoethylene (7) yields 1,1-diiodo-2,2-dinitroethylene (8). The latter reacts with alkylamines 9 or alkyldiamines 11 to give the corresponding acyclic 1,1-diamino-2,2-dinitroethylenes 10 or their cyclic analogs 12, resp. On the basis of liquid and solid-state 13C and 15N NMR data, x-ray anal. and ab initio calculations, we suggest that the title compounds are always zwitterionic and that the CA-CN bond is not a true double bond. Copyright © 2012 John Wiley & Sons, Ltd.

When you point to this article, it is believed that you are also very interested in this compound(1194-22-5)COA of Formula: C5H6N2O2 and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Biosynthesis of Fe3O4-magnetic nanoparticles using clover leaf aqueous extract: Green synthesis of 1,3-benzoxazole derivatives.Category: oxazolidine.

In this research, magnetic Fe3O4-NP nanoparticles were synthesized employing a green biosynthetic procedure by reduction of ferric chloride solution with clover leaf water extract The nanoparticles prepared via this biosynthesis method can potentially be valuable for different purposes such as organic synthesis. In this research, 1,3-benzoxazole derivatives were generated via a multicomponent reaction of α-bromo ketones, isothiocyanate, and propiolate in the presence of a catalytic amount of bio-Fe3O4 MNPs and sodium hydride in water at 50°C in good yields. The catalyst was reused five times with a minor decrease in its catalytic activity.

When you point to this article, it is believed that you are also very interested in this compound(70-23-5)Category: oxazolidine and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1194-22-5, is researched, SMILESS is CC1=NC(=CC(N1)=O)O, Molecular C5H6N2O2Journal, Journal of Heterocyclic Chemistry called Ylides of heterocycles. VII. Iodonium-, nitrogen-, phosphonium-, and sulfonium-ylides of pyrimidones, Author is Habib, Nargues Samuel; Kappe, Samuel, the main research direction is pyrimidinone ylide; iodonium ylide pyrimidinone; phosphonium ylide pyrimidinone; sulfonium ylide pyrimidinone; pyridinium ylide pyrimidinone; isoquinolinium ylide pyrimidinone.Electric Literature of C5H6N2O2.

Reaction of pyrimidinone I (R = OH; R1 = H, Me, Ph, R2 = H; R1 = R2 = Ph; R3 = H) with PhIO prepared in situ gave iodonium ylides I (R = O-, R3 = PhI+; II) in good yield. Thermal rearrangement of II gave I (R = OPh; R3 = iodo), which were deiodinated to give I (R = OPh, R3 = H). Treatment of II with pyridine, nicotinamide, isoquinoline, Ph3P, or thiophene gave the corresponding N, P, or S ylides. The pyridinium ylides were also prepared from I (R = OH, R1 = Br, Cl) which were prepared from II by treatment with HBr or HCl, resp.

When you point to this article, it is believed that you are also very interested in this compound(1194-22-5)Electric Literature of C5H6N2O2 and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Antimicrobial Chemotherapy called Repurposing ethyl bromopyruvate as a broad-spectrum antibacterial, Author is Kumar, Ajay; Boradia, Vishant Mahendra; Thakare, Ritesh; Singh, Alok Kumar; Gani, Zahid; Das, Swetarka; Patidar, Anil; Dasgupta, Arunava; Chopra, Sidharth; Raje, Manoj; Raje, Chaaya Iyengar, which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Synthetic Route of C5H7BrO3.

Background: The emergence of drug-resistant bacteria is a major hurdle for effective treatment of infections caused by Mycobacterium tuberculosis and ESKAPE pathogens. In comparison with conventional drug discovery, drug repurposing offers an effective yet rapid approach to identifying novel antibiotics. Methods: Et bromopyruvate was evaluated for its ability to inhibit M. tuberculosis and ESKAPE pathogens using growth inhibition assays. The selectivity index of Et bromopyruvate was determined, followed by time-kill kinetics against M. tuberculosis and Staphylococcus aureus. We first tested its ability to synergize with approved drugs and then tested its ability to decimate bacterial biofilm. Intracellular killing of M. tuberculosis was determined and in vivo potential was determined in a neutropenic murine model of S. aureus infection. Results: We identified Et bromopyruvate as an equipotent broad-spectrum antibacterial agent targeting drug-susceptible and -resistant M. tuberculosis and ESKAPE pathogens. Et bromopyruvate exhibited concentration-dependent bactericidal activity. In M. tuberculosis, Et bromopyruvate inhibited GAPDH with a concomitant reduction in ATP levels and transferrin-mediated iron uptake. Apart from GAPDH, this compound inhibited pyruvate kinase, isocitrate lyase and malate synthase to varying extents. Et bromopyruvate did not neg. interact with any drug and significantly reduced biofilm at a 64-fold lower concentration than vancomycin. When tested in an S. aureus neutropenic thigh infection model, Et bromopyruvate exhibited efficacy equal to that of vancomycin in reducing bacterial counts in thigh, and at 1/25th of the dosage. Conclusions: Et bromopyruvate exhibits all the characteristics required to be positioned as a potential broad-spectrum antibacterial agent.

When you point to this article, it is believed that you are also very interested in this compound(70-23-5)Synthetic Route of C5H7BrO3 and due to space limitations, I can only present the most important information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Modeling & simulation of micro reactor with nitration of 2-methyl-4,6-dihydroxy-pyrimidine. Author is Mandal, Alok Kumar; Pandey, Raj Kishore; Asthana, Shri Nandan; Kulkarni, Amol; Kulkarni, Bhaskar Dattatraya.

Nitration of 2-methyl-4,6-dihydroxypyrimidine (MDP) using concentrated sulfuric acid and nitric acid as nitrating mixture is a highly exothermic and hazardous reaction. Conducting such reaction in a batch reactor follow an unsteady state and its trajectory depends on various important parameters such as initial reactor temperature, initial composition of reaction mass, temperature of circulating coolant, etc. However, over all productivity, process control, and safety of the batch process is highly restricted due to lower surface to volume ratio. In the present work, an effort was made to over come the limitations of batch reactor by using the novel micro reactor device. Micro reactor is having extremely high surface to volume ratio, which was explored to carry out nitration of MDP both numerically as well as exptl. and the results were compared with conventional batch reactor. The micro reaction system was modeled using two dimensional (2-D) heat flow and mass transfer equations. The kinetic rate equation for nitration of MDP has evaluated exptl. by differential method which is used in modeling of the micro reactor. The numerical results from the 2-D model for conversion and temperature profile along the length and radius of micro reactor were compared with corresponding results obtained from batch reactor. In order to validate the model, several experiments were conducted in micro reactor set-up with the variation of flow rate, residence time, concentration, temperature, etc. The exptl. results from micro reactor revealed that nitration of MDP takes place even at much lower concentration and lower residence time with better control of temperature profile. Also, the reaction takes place in laminar region compared to turbulent region in corresponding batch reactor setup.

In some applications, this compound(1194-22-5)Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem