Tag: M.W:100-200

Related Products of 1194-22-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Novel dinitromethyl-featured polynitro energetic salts. Author is Li, Ying; Huang, Haifeng; Lin, Xiangyang; Pan, Renming; Yang, Jun.

A unique and facile method was developed to synthesize a new class of energetic salts based on 2-amino-1,1,5,5-tetranitro-4-oxo-3-aza-pentene. All the salts were fully characterized by NMR (1H and 13C), IR spectroscopy and elemental anal. Furthermore, the crystal structure of the guanidinium salt was determined by single-crystal X-ray diffraction. The differential scanning calorimetry (DSC) results showed that the decomposition temperatures of these salts were between 126.2 °C and 148.8 °C. The densities of these salts lie in the range of 1.745 to 1.880 g cm-3. Their impact sensitivities and friction sensitivities were measured to be in the range of 1-16 J and 48-84 N, resp. All the salts exhibited promising detonation performances (detonation pressure: 28.6 to 34.3 GPa; detonation velocity: 8037 to 8674 m s-1), and the detonation performances of one of the salts were comparable to those of RDX.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 5451-40-1, is researched, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic Chemistry called 6-Substituted purines as ROCK inhibitors with anti-metastatic activity, Author is Voller, Jiri; Zahajska, Lenka; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Pataki, Andreea Csilla; Krystof, Vladimir; Zatloukal, Marek; Brabek, Jan; Rosel, Daniel; Mik, Vaclav; Tkac, Martin; Pospisil, Tomas; Gucky, Tomas; Dolezal, Karel; Strnad, Miroslav, the main research direction is melanoma antitumor antimetastasis purine ROCK2; Anti-metastatic activity; Melanoma; Protein kinase inhibitor; ROCK.Safety of 2,6-Dichloropurine.

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1194-22-5, is researched, Molecular C5H6N2O2, about Methyl 2-(benzoylamino)-3-(dimethylamino)propenoate in the synthesis of fused pyranones. The synthesis of derivatives of tetrahydro-2H-1-benzopyran-2-one, isomeric 2H-naphtho[1,2-b]pyran-2-one and 3H-naphtho[2,1-b]pyran-3-one, pyrano[3,2-c]benzopyran-2,5-dione, and 7H-pyrano[2,3-d]pyrimidin-7-one, the main research direction is benzoylaminodimethylaminopropenoate cyclocondensation diketone; pyranone fused; benzopyranone tetrahydro; naphthopyranone; pyranobenzopyrandione; pyranopyrimidinone.Electric Literature of C5H6N2O2.

Me 2-benzoylamino-3-dimethylaminopropenoate (I) reacts with carbocyclic and heterocyclic 1,3-diketones or potential 1,3-diketones, such as 1,3-cyclohexanediones, and 4-hydroxy-2H-1-benzopyran-2-one derivatives, in acetic acid to afford the corresponding 3-benzoylamino substituted 5-oxo-5,6,7,8-tetrahydro-2H-benzopyran-2-ones, and 2H,5H-pyrano[3,2-c][1]benzopyran-2,5-dione derivatives. 1-Naphthol and 2-naphthol produce the isomeric 2H-naphtho[1,2-b]pyran-2-one and 3H-naphtho[2,1-b]pyran-3-one derivatives, resp. Et cyclopentanone-2-carboxylate and Et cyclohexanone-2-carboxylate do not react under these conditions, while in polyphosphoric acid the cyclization of the reagent I is taking place to give 4-dimethylaminomethylene-2-phenyl-5(4H)-oxazolone. 4,6-Dihydroxypyrimidine derivative I affords in acetic acid the noncyclized intermediate II, which can be further transformed in polyphosphoric acid into 7H-pyrano[2,3-d]pyrimidin-7-one derivative III.

From this literature《Methyl 2-(benzoylamino)-3-(dimethylamino)propenoate in the synthesis of fused pyranones. The synthesis of derivatives of tetrahydro-2H-1-benzopyran-2-one, isomeric 2H-naphtho[1,2-b]pyran-2-one and 3H-naphtho[2,1-b]pyran-3-one, pyrano[3,2-c]benzopyran-2,5-dione, and 7H-pyrano[2,3-d]pyrimidin-7-one》,we know some information about this compound(1194-22-5)Electric Literature of C5H6N2O2, but this is not all information, there are many literatures related to this compound(1194-22-5).

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Cross dehydrogenation coupling reaction of purine derivatives with thioethers, the main research direction is purine thioether cross dehydrogenation coupling reaction; benzimidazole regioselective preparation.Computed Properties of C5H2Cl2N4.

A metal-free cross-dehydrogenation coupling method was established to synthesize N9 alkylated purine derivatives Using PhI(OAc)2 as the oxidant, versatile thioethers were successfully employed as alkylation reagents. Under the optimized conditions, a variety of alkylated purine derivatives and other aromatic N-heterocycles were obtained in moderate to good yields. The regioselectivity of this protocol which involves the reaction of unsym. thioethers with purine derivatives was also studied.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Chen, Hanping; Lin, Guiying; Chen, Yingquan; Chen, Wei; Yang, Haiping published the article 《Biomass Pyrolytic Polygeneration of Tobacco Waste: Product Characteristics and Nitrogen Transformation》 about this compound( cas:1194-22-5 ) in Energy & Fuels. Keywords: biomass pyrolysis polygeneration tobacco waste nitrogen transformation. Let’s learn more about this compound (cas:1194-22-5).

Conversion of waste to high-value products by pyrolysis is a suitable and harmless disposal technol. for the abundant waste generated in the tobacco industry. To determine the optimum operational parameters for biomass pyrolytic polygeneration using tobacco waste as the feedstock, the product characteristics and N transformation were studied from 250 to 950°. The highest low calorific values of gas and char were 13 MJ/m3 at 750° and 15 MJ/kg at 450°, resp. The optimum operating temperature recommended for biomass pyrolytic polygeneration of tobacco waste is 650° when the 3 products (char, oil, and gas) are balanced. The char formation process is divided into 3 stages: degradation (250-450°), reforming (450-650°), and condensation (>650°). Three types of N-containing structures are formed in chars: pyridinic N, pyrrolic/pyridine N, and quaternary N. Pyridinic N is dominant at low temperatures, whereas quaternary N becomes dominant at high temperatures N-containing volatiles escape from chars with increasing temperature and are primarily found in oil <550° and in gas >650°. N-containing compounds are the major components (up to 45%) in the organic portion of oil, with pyridines, pyrroles, and piperidines as the dominant forms. In the gas product, NH3 and HCN are the major N-containing compounds released >650°. This study is expected to be beneficial for the comprehensive use of tobacco waste.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Spectroscopic Study of the Basicity of 4,6-Dihydroxypyrimidine Derivatives. Author is Vu, Tuan Q.; Yudin, Nikolai V.; Kushtaev, Alexander A.; Nguyen, Thanh X.; Maltsev, Sergey A..

The protonation of a number of 4,6-dihydroxypyrimidine derivatives is studied, and the features of the electronic spectra of free bases and protonated forms are considered. It is shown that the alkyl substituents in position 2 increase the basicity of the compound, and the nitro group in position 5 leads to its decrease. In an acid medium (0.1-99.5% H2SO4), 4,6-dihydroxypyrimidine, 6-hydroxy-2-methylpyrimidine-4(3H)-one, and 6-hydroxy-2-ethylpyrimidine-4(3H)-one have two protonation stages, barbituric acid is protonated in three stages, and 6-hydroxy-2-methyl-5-nitropyrimidine-4(3H)-one and 6-hydroxy-2-ethyl-5-nitropyrimidine-4(3H)-one form a monocation.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 70-23-5, is researched, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3Journal, Article, Combinatorial Chemistry & High Throughput Screening called Green synthesis of 4H-pyran derivatives using Fe3O4-MNPs as efficient nanocatalyst: study of antioxidant activity, Author is Shafaei, Faezeh; Najar, Asef H., the main research direction is iron oxide magnetic nanoparticle preparation; dialkyl oxo dihydroindenopyran dicarboxylate green preparation antioxidant; ninhydrin haloketone dialkyl acetylenedicarboxylate triphenylphosphine multicomponent iron oxide nanocatalyst; Diels-Alder reactions; Fe3O4-MNPs; Ninhydrine; Pyran; green synthesis; α-haloketones.Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

A series of dialkyl 4-(oxo-alkoxy/aryl)-5-oxo-4,5-dihydroindeno[1,2-b]pyran-2,3-dicarboxylates I [R = CO2Et, 4-MeC6H4, 4-BrC6H4, etc.; R1 = Me, Et] was synthesized via a multicomponent reaction of ninhydrin, α-haloketones, dialkyl acetylenedicarboxylates and triphenylphosphine in the presence of iron oxide magnetic nanoparticles (Fe3O4-MNPs) as efficient nanocatalyst in ethanol at room temperature The biosynthesis of Fe3O4-MNPs was achieved using Clover Leaf water extract In addition, antioxidant activity was examined for some of the compounds I [R = CO2Et, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4; R1 = Me, Et] employing DPPH radical scavenging and ferric reduction activity potential (FRAP) experiment and compared results with synthetic antioxidants (TBHQ and BHT). Compound I [R = CO2Et; R1 = Et] showed excellent radical trapping activity and good reducing activity relative to standards (BHT and TBHQ). Some advantages of this procedure were easiness of reaction workup and seperation of products by simply filtration. Fe3O4-MNPs displayed a good improvement in the yield of the product and showed significant reusable activity.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application of 5451-40-1. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Purine Unit as a Building Block of Artificial Receptors Designed for the Recognition of Carbohydrates. Author is Kaiser, Stefan; Geffert, Christoph; Mazik, Monika.

1,3,5-Substituted 2,4,6-triethylbenzene derivatives bearing pyridine/pyrimidine and purine units were synthesized and their potential to function as carbohydrate receptors was evaluated. Compounds consisting of 2-chloro-9H(7H)-purin-6-yl unit (e.g., I) have the ability to act both as carbohydrate-binding agents and as a basis for further functionalization through the nucleophilic displacement of the chlorine atom. Microwave-assisted reactions and/or the application of sealed tubes allowed the preparation of derivatives with a varying substituent pattern on the purine ring. The relatively drastic reaction conditions required for the successful functionalization reflect the unfavorable influence of the bulky C6-substituent on the nucleophilic substitution at purine C2. Initial binding studies towards carbohydrates showed that the properties of this type of purine-bearing compounds can be fine-tuned by the variation of the C2-substituent of the purine ring and represents a valuable basis for the identification of new structure-activity relationships. Such findings are of high importance for further developments in the area of mol. recognition of carbohydrates by artificial receptors.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Development of a quinolinium/cobaloxime dual photocatalytic system for oxidative C-C cross-couplings via H2 release, the main research direction is quinoline photocatalyst oxidative cross coupling Minisci alkylation photocyclization.Synthetic Route of C5H2Cl2N4.

Designing mol. photocatalysts for potent photochem. reactivities ranks among the most challenging but rewarding endeavors in synthetic photochem. Herein, we document a quinoline-based organo-photoredox catalyst, 2,4-bis(4-methoxyphenyl)quinoline (DPQN2,4-di-OMe), that could be assembled via the facile aldehyde-alkyne-amine (A3) couplings. Unlike the reported photocatalysts, which impart their photoreactivities as covalently linked entities, our mechanistic studies suggested a distinct proton activation mode of DPQN2,4-di-OMe. Simply upon protonation, DPQN2,4-di-OMe could reach a highly oxidizing excited state under visible-light irradiation (E*1/2 = +1.96 V vs a standard calomel electrode, SCE). On this basis, the synergistic merger of DPQN2,4-di-OMe and cobaloxime formulated an oxidative cross-coupling platform, enabling the Minisci alkylation and various C-C bond-forming reactions with a diverse pool of radical precursors in the absence of chem. oxidants. The catalytic loading of DPQN2,4-di-OMe could be minimized to 0.025 mol % (TON = 3360), and a polymer-supported photocatalyst, DPQN2,4-di-OR@PS, was prepared to facilitate catalyst recycling (at a 0.50 mmol % loading and up to five times without significant loss of photosynthetic efficiency).

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Kinetic and spectral investigation of the electron and hydrogen adducts of dihydroxy- and dimethyl-substituted pyrimidines: A pulse radiolysis and product analysis study.COA of Formula: C5H6N2O2.

The reactions of hydrated electrons (eaq-) and hydrogen atoms (H•) with 4,6-dihydroxy-2-methylpyrimidine (DHMP), 2,4-dimethyl-6-hydroxypyrimidine (DMHP), 5,6-dimethyluracil (DMU) and 6-methyluracil (MU) were studied at different pH values using pulse radiolysis. The second-order rate constants obtained for the reaction of eaq- with these systems are in the range (5-10) × 109 dm3 mol-1 s-1 at near, neutral pH. At basic pH, the rate constant values were considerably reduced owing to the electrostatic effect between eaq- and pyrimidine anion. The transient absorption spectra of the electron adducts have distinct absorption maxima at around 300-320 nm. The initial spectrum in the case of DHMP at pH 4.5 was found to undergo a first-order transformation. Based on the spectral characteristics and the yields of methylviologen radical cation (MV.+) resulted from the electron transfer reaction between the electron adducts and MV2+, it is proposed that a protonated (at oxygen) electron adduct of DHMP is initially formed which undergoes a proton- and phosphate-catalyzed transformation to form a reducing C(5) protonated C(6)-yl radical. Such preferential protonation at C(5) is predominant only with dihydroxypyrimidine systems. At pH 9 and 13, formation of a radical monoanion of DHMP (pKa ≥ 13) is proposed. The possible attack of eaq- is proposed to be at N(1) or N(3) of DMHP. The resulting electron adduct has a pKa value around 6.0. Similar properties for the electron adducts of DMU and MU [electron attack at O(4)] are proposed. The second-order rate constants for H. with DHMP, DMHP, DMU and MU were in the range (1.7-28) × 108 dm3 mol-1 s-1. The hydrogen adduct spectra were generally identified as their absorption maxima at 310-380 and 460-510 nm. Formation of C(5)-protonated C(6)-yl radical, the same radical that formed after the H+-and phosphate-catalyzed transformation of the electron adduct, is proposed for DHMP. The possibility of the formation of C(5)-yl and C(6)-yl H adducts of DMHP, DMU and MU is discussed. High-performance liquid chromatog. coupled with electrospray mass spectrometry (HPLC-ES-MS) has been used to qual. analyze the products obtained from the reaction of eaq- with DHMP and DMHP and the results revealed that the products are mainly derived from the C(5) protonated C(6)-yl radicals via its disproportionation and dimerization reaction. A possible reaction mechanism is proposed for the product formation.

Compound(1194-22-5)COA of Formula: C5H6N2O2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one), if you are interested, you can check out my other related articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem