Tag: M.W:100-200

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts.

The coupling constants of the radicals produced in aqueous solution by reaction of the hydrated electron with uracil and thymine and with their nucleosides and nucleotides were determined using the in situ radiolysis ESR method. From the coupling constants of these electron adducts it is evident that the unpaired spin d. at C(6) of the pyrimidine ring is much larger than that at C(5). Substitution with Me, carboxyl, or ribosyl groups at C(5), C(6), and N(1), resp., has little effect on the distribution of the unpaired spin. The splittings of the radicals measured in aqueous solution are very similar to those previously reported for the same radicals in the solid state, which shows that the latter data are of predictive value also for the aqueous phase. At pH 7 in the presence of phosphate the electron adducts are converted into 6-dihydropyrimidin-5-yl radicals by protonation on C(6). The protonation reaction has previously been observed to occur in the solid state. In comparison, the hydrogen atom reacts with uracil to give the 5-dihydro-6-yl radical. The uracil isomer 4,6-dihydroxypyrimidine, and its 2- and 5-Me derivative react with the hydrated electron to give delocalized radical anions, which on protonation by H+ are converted into the 5-dihydro-2-yl radicals. This conversion, which can also be catalyzed by phosphate, is more efficient than in the case of uracil. The hydrogen atom reacts with the 4,6-dihydroxypyrimidine system by addition at C(5) to give the same radical as that from the reaction with the hydrated electron followed by protonation. With the electron adduct of 4,6-dihydroxypyrimidine, a OH- catalyzed protonation by water on C(5) is observed

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Goh, Eun Mee; Kim, Hyoun-Soo published the article 《The scale up process improvement of 1,1-diamino-2,2-dinitroethane (DADNE)》 about this compound( cas:1194-22-5 ) in New Trends in Research of Energetic Materials, Proceedings of the Seminar, 13th, Pardubice, Czech Republic, Apr. 21-23, 2010. Keywords: explosive diaminodinitroethane synthesis scaleup safety. Let’s learn more about this compound (cas:1194-22-5).

1,1-Diamino-2,2-dinitroethane (DADNE) is a novel explosive with low sensitivity and high performance. The nitration process of 4,6-dihydroxy-2-Me pyrimidine was enhanced using organic solvent. The temperature of reaction in nitration step is preferably 20-40°. The reaction time of step is 2 h. After nitration process, for the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-dinitromethylene-2,5-dihydropyrimidine, wherein heating reactant is applies in the hydrolysis, thereby solving the safety problem while improving the reaction time of hydrolysis.

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Formula: C5H6N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Synthesis, spectral characterizations and biological applications of novel 3-[(E)-(4, 6-dihydroxy pyrimidin-5-yl)diazenyl]-4-methylbenzoic acid azo Dye and their derivatives. Author is Prashantha, A. G.; Keshavayya, J.; Shoukat Ali, R. A..

Novel derivatives of amino-methylbenzoic acid and Pyrimidine-4,6-diol based heterocyclic azo dyes (5-7) were reported. Synthesis was carried out by diazotization of amino-methylbenzoic acid (1) and followed by coupling with different derivatives of Pyrimidine-4,6-diol based coupling components such as Pyrimidine-4,6-diol(2), 2-Me pyrimidine-4,6-diol(3), 2-aminopyrimidine-4,6-diol(4) under suitable exptl. condition. The azo dyes obtained are orange-red in color and they are characterized by various anal. methods like IR, UV-Vis, 1H NMR, 13C NMR and Mass spectral techniques etc. The synthesized compounds were screened for their biol. activities and the result was compared with the standards

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Formula: C5H6N2O2, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Pyrimidines. IV. 2-, 5-, and 2,5-substituted chloropyrimidines, the main research direction is ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; LEUKEMIA L1210; MICE; NEOPLASMS, EXPERIMENTAL; PHARMACOLOGY; PYRIMIDINES; SARCOMA 180, CROCKER; TISSUE CULTURE.Recommanded Product: 1194-22-5.

cf. CA 58, 9061g. Condensation of the appropriate amidine or urea with the corresponding Et malonate in the presence of NaOEt and the 4,6-pyrimidinediol treated with POCl3, POCl3-PhNMe2, or POCl3-PCl5 gave the Cl-substituted pyrimidines. The amidines were prepared according to Pinner [Ber. 17, 171(1884)], and details were given for preparation of anhydrous PhC(: NH)NH2.HCl, in 37.6% yields. Pertinent data on the 2-, 5-, and 2,5-substituted pyrimidines (I) and uv spectra data for the ring-polychlorinated pyrimidines were summarized. I (R = Me, R1 = Cl, R2 = Me, R3 = Cl) and I (R = ClCH2, R1 = Cl, R2 = Me, R3 = Cl) were converted to the 5-bromomethyl derivatives by treatment with (CH2CO)2NBr in the presence of Bz2O2. All compounds were screened against at least 3 mouse tumors and the data tabulated. A series of 5-substituted 2,4,6-trichloropyrimidines showed confirmed activity in the KB cell culture test system and the screening data were summarized.

Here is a brief introduction to this compound(1194-22-5)Recommanded Product: 1194-22-5, if you want to know about other compounds related to this compound(1194-22-5), you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Enzyme Inhibition and Medicinal Chemistry called TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition, Author is Lee, Seulgi; Park, Bernie Byeonghoon; Kwon, Hongmok; Kim, Vitchan; Jeon, Jang Su; Lee, Rowoon; Subedi, Milan; Lim, Taehyeong; Ha, Hyunsoo; An, Dongju; Kim, Jaehoon; Kim, Donghak; Kim, Sang Kyum; Kim, Seyun; Byun, Youngjoo, which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, Quality Control of 2,6-Dichloropurine.

Inositol hexakisphosphate kinase (IP6K) is an important mammalian enzyme involved in various biol. processes such as insulin signalling and blood clotting. Recent analyses on drug metabolism and pharmacokinetic properties on TNP (N2-(m-trifluorobenzyl), N6-(p-nitrobenzyl)purine), a pan-IP6K inhibitor, have suggested that it may inhibit cytochrome P 450 (CYP450) enzymes and induce unwanted drug-drug interactions in the liver. In this study, we confirmed that TNP inhibits CYP3A4 in type I binding mode more selectively than the other CYP450 isoforms. In an effort to find novel purine-based IP6K inhibitors with minimal CYP3A4 inhibition, we designed and synthesized 15 TNP analogs. Structure-activity relationship and biochem. studies, including ADP-Glo kinase assay and quantification of cell-based IP7 production, showed that compound dramatically reduced CYP3A4 inhibition while retaining IP6K-inhibitory activity. Compound can be a tool mol. for structural optimization of purine-based IP6K inhibitors.

Here is a brief introduction to this compound(5451-40-1)Quality Control of 2,6-Dichloropurine, if you want to know about other compounds related to this compound(5451-40-1), you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Application of 1194-22-5.Astrat’ev, A. A.; Dashko, D. V.; Mershin, A. Yu.; Stepanov, A. I.; Urazgil’deev, N. A. published the article 《Some specific features of acid nitration of 2-substituted 4,6-dihydroxypyrimidines. Nucleophilic cleavage of the nitration products》 about this compound( cas:1194-22-5 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: nitration pyrimidinediol; nitropyrimidine preparation hydrolysis; nitroethylenediamine preparation. Let’s learn more about this compound (cas:1194-22-5).

The nitration of 2-substituted 4,6-dihydroxypyrimidines in concentrated sulfuric acid yields the corresponding 5,5-dinitro derivatives When the substituent in position 2 is an alkyl group, the nitration occurs both at position 5 and at the α-carbon atom of the side chain. Hydrolysis of 2-substituted 4,6-dihydroxy-5,5-dinitropyrimidines leads to formation of 1,1-diamino-2-R-2-nitroethylene derivatives 1,1-Diamino-2,2-dinitroethylene was obtained by nitration of 4,6-dihydroxy-2-methylpyrimidine and subsequent hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine.

Here is a brief introduction to this compound(1194-22-5)Application of 1194-22-5, if you want to know about other compounds related to this compound(1194-22-5), you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Category: oxazolidine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Efficient synthesis of α-branched purine-based acyclic nucleosides: scopes and limitations of the method. Author is Frydrych, Jan; Slaveetinska, Lenka Postova; Draccinsky, Martin; Janeba, Zlatko.

An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety was reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employed cheap and easily available acetals, acetic anhydride, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). The multi-component reaction was carried out in acetonitrile at room temperature for 15 min and provides moderate to high yields (up to 88%) of diverse acyclonucleosides branched at the aliphatic side chain. The procedure exhibited a broad substrate scope of N-heterocycles and acetals, and, in the case of purine derivatives, also excellent regioselectivity, giving almost exclusively N-9 isomers.

Here is a brief introduction to this compound(5451-40-1)Category: oxazolidine, if you want to know about other compounds related to this compound(5451-40-1), you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Formula: C5H2Cl2N4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Author is Lee, Yoonji; Hou, Xiyan; Lee, Jin Hee; Nayak, Akshata; Alexander, Varughese; Sharma, Pankaz K.; Chang, Hyerim; Phan, Khai; Gao, Zhan-Guo; Jacobson, Kenneth A.; Choi, Sun; Jeong, Lak Shin.

Distinguishing compounds′ agonistic or antagonistic behavior would be of great utility for the rational discovery of selective modulators. We synthesized truncated nucleoside derivatives and discovered 6c (I)(Ki = 2.40 nM) as a potent human A3 adenosine receptor (hA3AR) agonist, and subtle chem. modification induced a shift from antagonist to agonist. We elucidated this shift by developing new hA3AR homol. models that consider the pharmacol. profiles of the ligands. Taken together with mol. dynamics (MD) simulation and three-dimensional (3D) structural network anal. of the receptor-ligand complex, the results indicated that the hydrogen bonding with Thr943.36 and His2727.43 could make a stable interaction between the 3′-amino group with TM3 and TM7, and the corresponding induced-fit effects may play important roles in rendering the agonistic effect. Our results provide a more precise understanding of the compounds′ actions at the at. level and a rationale for the design of new drugs with specific pharmacol. profiles.

If you want to learn more about this compound(2,6-Dichloropurine)Formula: C5H2Cl2N4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(5451-40-1).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application In Synthesis of Ethyl 3-bromo-2-oxopropanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Design, synthesis, in vitro evaluation and molecular docking study of N’-arylidene imidazo[1,2-a]pyridine -2-carbohydrazide derivatives as novel tyrosinase inhibitors.

A novel series of imidazo[1,2-a]pyridine 2-carbohydrazide derivatives bearing different arylidene pendants I [R = 4-OH, 2-MeO, 3-OH-4-MeO, etc.] were designed, synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. It was found that compounds I [R = 3-NO2, 4-OH] exhibited the best tyrosinase inhibitory activity with IC50 values of 7.19 and 8.11μM, resp. These results were comparable to that of kojic acid as the reference drug (IC50 = 9.64±0.5μM). Addnl., mol. docking anal. was performed to study the interactions and binding modes of compounds I [R = 3-NO2, 4-OH, 2,4-di-OH] which showed the potential of two critical pi-pi interactions with His263 and Phe264 in the active site of tyrosinase. The results indicated that compounds I [R = 3-NO2, 4-OH] could be introduced as potent tyrosinase inhibitors that might serve as promising candidates in medicine, cosmetics or food industry.

If you want to learn more about this compound(Ethyl 3-bromo-2-oxopropanoate)Application In Synthesis of Ethyl 3-bromo-2-oxopropanoate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(70-23-5).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic Chemistry called Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site, Author is Hu, Xi; Li, Lu; Zhang, Qiangsheng; Wang, Qianqian; Feng, Zhanzhan; Xu, Ying; Xia, Yong; Yu, Luoting, which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, SDS of cas: 5451-40-1.

A series of 3-(((9H-purin-6-yl)amino)methyl)pyridin-2(1H)-one derivatives were designed, synthesized and confirmed as tubulin polymerization inhibitors. All compounds were evaluated for their anti-proliferative activities on three colorectal carcinoma (CRC) cell lines. Among these compounds, SKLB0565 displayed noteworthy potency against eight CRC cell lines with IC50 values ranging from 0.012μM and 0.081μM. Besides, SKLB0565 inhibited tubulin polymerization, caused G2/M phase cell cycle arrest, depolarized mitochondria and induced cell apoptosis in CRC cells. Furthermore, SKLB0565 suppressed cell migration and disrupted the capillary tube formation of human umbilical vein endothelial cells (HUVECs). In this SKLB0565 is a promising anti-tubulin agent for CRC therapy which is worthy of further evaluation is clarified.

If you want to learn more about this compound(2,6-Dichloropurine)SDS of cas: 5451-40-1, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(5451-40-1).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem