Tag: M.W:200-300

Jiang, Jie; Seel, Catharina Julia; Temirak, Ahmed; Namasivayam, Vigneshwaran; Arridu, Antonella; Schabikowski, Jakub; Baqi, Younis; Hinz, Sonja; Hockemeyer, Joerg; Mueller, Christa E. published the article 《A2B Adenosine Receptor Antagonists with Picomolar Potency》. Keywords: A2B adenosine receptor antagonist benzenesulfonamide.They researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Computed Properties of C12H16N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67914-60-7) here.

The A2B adenosine receptor (A2BAR) was proposed as a novel target for the (immuno)therapy of cancer since A2BAR blockade results in antiproliferative, anti-angiogenic, anti-metastatic, and immuno-stimulatory effects. In this study, we explored the structure-activity relationships of xanthin-8-yl-benzenesulfonamides mainly by introducing a variety of linkers and substituents attached to the sulfonamide residue. A new, convergent strategy was established which facilitated the synthesis of the target compounds Many of the new compounds exhibited subnanomolar affinity for the A2BAR combined with high selectivity. Functional groups were introduced which will allow the attachment of dyes and other reporter groups. 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine (34, PSB-1901) was the most potent A2B-antagonist (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10,000-fold selectivity vs. all other AR subtypes. It was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclin. studies. Computational studies predicted halogen bonding to contribute to the outstanding potency of 34.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dong, Yan; Li, Kehuang; Xu, Zhixiang; Ma, Haikuo; Zheng, Jiyue; Hu, Zhilin; He, Sudan; Wu, Yiyuan; Sun, Zhijian; Luo, Lusong; Li, Jiajun; Zhang, Hongjian; Zhang, Xiaohu researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).SDS of cas: 67914-60-7.They published the article 《Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors》 about this compound( cas:67914-60-7 ) in Bioorganic & Medicinal Chemistry. Keywords: protein palmitoyltransferase Porcupine antagonist synthesis inhibitor Wnt signaling secretion; Antagonist; Cancer therapy; Porcupine; Scaffold hybridization; Wnt signaling pathway. We’ll tell you more about this compound (cas:67914-60-7).

The Wnt signaling pathway is a pivotal developmental pathway. It operates through control of cellular functions such as proliferation, differentiation, migration and polarity. Aberrant Wnt signaling has been implicated in the formation and metastasis of tumors. Porcupine is a component of the Wnt signaling pathway. It is a member of the membrane-bound O-acyltransferase family of proteins. Porcupine catalyzes the palmitoylation of Wnt proteins, a process which is essential to their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from two known porcupine inhibitor classes. The leading compound 62 demonstrated subnanomolar (IC50 0.11 nM) inhibition of Wnt signaling in a paracrine cellular reporter gene assay. Compound 62 also potently inhibited Wnt secretion into culture medium, an indication of direct inhibition of the porcupine protein. Furthermore, compound 62 showed excellent chem., plasma and liver microsomal stabilities. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

《Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)SDS of cas: 67914-60-7.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 67914-60-7, is researched, Molecular C12H16N2O2, about Antibacterial and antifungal agents. XV. Synthesis and antifungal activity of structural analogs of bifonazole and ketoconazole, the main research direction is antifungal activity bifonazole ketoconazole; dioxolanylmethoxy phenyl piperazine.Formula: C12H16N2O2.

The synthesis and antifungal activities of the cis- and trans-1-acetyl-4-{4-[[2-(1,1′-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl}piperazines I are reported. Stereochem. assignments to diastereomeric pairs of cis/trans isomers were made on the basis of 1H and 13C NMR data. Among test derivatives the best activity was shown by the benzoyl esters of the cis- and trans-[2-(1,1′-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methanols II (R = H, SO2CH3).

《Antibacterial and antifungal agents. XV. Synthesis and antifungal activity of structural analogs of bifonazole and ketoconazole》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Formula: C12H16N2O2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Substituted phthalocyanines and their electropolymerization properties, published in 2016-10-31, which mentions a compound: 67914-60-7, Name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, Molecular C12H16N2O2, Formula: C12H16N2O2.

New metal-free and metallo-phthalocyanine complexes (Co, TiO) were synthesized using a piperazine-substituted phthalonitrile derivative All proposed structures were supported by instrumental methods. Electrochem. studies of H2-Pc, TiIVOPc, and CoIIPc were examined using cyclic voltammetry (CV) and square-wave voltammetry (SWV) techniques. Voltammetric analyses of phthalocyanines supported the proposed structure of the synthesized complexes. All studied phthalocyanines were oxidatively electropolymerized on the working electrode during the repetitive anodic potential scans.

《Substituted phthalocyanines and their electropolymerization properties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Formula: C12H16N2O2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7789-45-9, is researched, SMILESS is [Cu+2].[Br-].[Br-], Molecular Br2CuJournal, Article, Inorganic Chemistry called High-temperature phase transition containing switchable dielectric behavior, long fluorescence lifetime, and distinct photoluminescence changes in 2D hybrid CuBr4 perovskite, Author is Han, Ding-Chong; Tan, Yu-Hui; Wu, Wei-Chao; Li, Yu-Kong; Tang, Yun-Zhi; Zhuang, Jia-Chang; Ying, Ting-Ting; Zhang, Hao, the main research direction is phase transition switchable dielec behavior fluorescence hybrid perovskite.SDS of cas: 7789-45-9.

A novel organic-inorganic hybrid perovskite crystal, [ClC6H4(CH2)2NH3]2CuBr4 (1), having experienced an invertible high-temperature phase transition near Tc (Curie temperature Tc = 355 K), has been successfully synthesized. The phase-transition characteristics for compound 1 are thoroughly revealed by sp. heat capacity (Cp), DTA, and differential scanning calorimetry tests, possessing 16 K broad thermal hysteresis. Multiple-temperature powder X-ray diffraction anal. further proves the phase-transition behavior of compound 1. Moreover, compound 1 exhibits a significant steplike dielec. response near Tc, revealing that it can be deemed to be a promising dielec. switching material. The variable-temperature fluorescence experiments show distinct photoluminescence (PL) changes of compound 1. Further investigation and calculation disclose that the fluorescence lifetime of compound 1 can reach as long as 55.46 μs, indicating that it can be a potential PL material. All of these researches contribute a substitutable avenue in the design and construction of neoteric phase-transition compounds combining high Curie temperature and PL properties.

《High-temperature phase transition containing switchable dielectric behavior, long fluorescence lifetime, and distinct photoluminescence changes in 2D hybrid CuBr4 perovskite》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Cupric bromide)SDS of cas: 7789-45-9.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Cupric bromide(SMILESS: [Cu+2].[Br-].[Br-],cas:7789-45-9) is researched.Electric Literature of C5H7BrO3. The article 《A novel rechargeable metal halides battery with ethylene glycol cyclic sulfate electrolyte system》 in relation to this compound, is published in Materials Letters. Let’s take a look at the latest research on this compound (cas:7789-45-9).

Metal halides have become the research topic of battery due to their high energy d. In our work, we synthesized ethylene glycol cyclic sulfate (egcs) as the electrolyte solvent through a simple one-step hydrothermal reaction, and for the first time proposed a new non-toxic rechargeable copper bromide (CuBr2) battery with a complete system. After testing, the specific capacity of the CuBr2-battery with the electrolyte of this system can reach 200 mAh g-1cb at the charging and discharging c.d. of 2 A g-1. The specific capacity can still reach 142 mAh g-1cb after 8000 cycles. In addition, the reaction mechanism of CuBr2-battery was verified by XPS, IR, MS and XRD characterization.

The article 《A novel rechargeable metal halides battery with ethylene glycol cyclic sulfate electrolyte system》 also mentions many details about this compound(7789-45-9)Name: Cupric bromide, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Formula: C12H16N2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Synthesis of 6-[4-(4-Propoxyphenyl)piperazin-1-yl]-9H-purine Derivatives as Antimycobacterial and Antifungal Agents: In Vitro Evaluation and In Silico Study.

A series of novel alkyl substituted purines were synthesized. 6-[4-(4-Propoxyphenyl)piperazin-1-yl]-9H-purine was used as the key starting material, which was synthesized via a multistep protocol and finally subjected for N-alkylation with various alkyl halides with an aim to get prospective antimicrobial agents. The structures of the novel compounds were established by substantiating them through spectral techniques like 1H-NMR, 13C-NMR, FT-IR and EI-MS. They were explored for antitubercular activity against Mycobacterium tuberculosis H37RV. Furthermore, they were checked for their antimicrobial activity concerning bacterial and fungal strains. The title compounds exhibited considerable antimicrobial activity without any significant toxicity. In silico studies depicted their good binding profile against Mycobacterium tuberculosis enoyl reductase (InhA; PDB ID: 4TZK) and Candida albicans dihydrofolate reductase (PDB ID: 1AI9). The title compounds obeyed Lipinski’s parameters and have exhibited good drug-like properties.

The article 《Synthesis of 6-[4-(4-Propoxyphenyl)piperazin-1-yl]-9H-purine Derivatives as Antimycobacterial and Antifungal Agents: In Vitro Evaluation and In Silico Study》 also mentions many details about this compound(67914-60-7)Formula: C12H16N2O2, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Assemblies of polyacrylonitrile-derived photoactive polymers as blue and green light photo-cocatalysts for Cu-catalyzed ATRP in water and organic solvents, published in 2021, which mentions a compound: 7789-45-9, Name is Cupric bromide, Molecular Br2Cu, Name: Cupric bromide.

Photoluminescent nanosized quasi-spherical polymeric assemblies prepared by the hydrothermal reaction of polyacrylonitrile (PAN), ht-PLPPAN, were demonstrated to have the ability to photo-induce atom transfer radical polymerization (ATRP) catalyzed by low, ppm concentrations of CuII complex with tris(2-pyridylmethyl)amine (TPMA). Such photo induced ATRP reactions of acrylate and methacrylate monomers were performed in water or organic solvents, using ht-PLPPAN as the photo-cocatalyst under blue or green light irradiation Mechanistic studies indicate that ht-PLPPAN helps to sustain the polymerization by facilitating the activation of alkyl bromide species by two modes: (1) green or blue light-driven photoreduction of the CuII catalyst to the activating CuI form, and (2) direct activation of dormant alkyl bromide species which occurs only under blue light. The photoreduction of the CuII complex by ht-PLPPAN was confirmed by linear sweep voltammetry performed under illumination. Anal. of the polymerization kinetics in aqueous media indicated even though CuI complexes comprised only 1-1.4% of all Cu species at equilibrium, they exhibited high activation rate constant and activated the alkyl bromide initiators five to six orders of magnitude faster than ht-PLPPAN.

The article 《Assemblies of polyacrylonitrile-derived photoactive polymers as blue and green light photo-cocatalysts for Cu-catalyzed ATRP in water and organic solvents》 also mentions many details about this compound(7789-45-9)Name: Cupric bromide, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors, published in 2014, which mentions a compound: 67914-60-7, Name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, Molecular C12H16N2O2, Related Products of 67914-60-7.

The influenza RNA polymerase complex, which consists of the three subunits PA, PB1, and PB2, is a promising target for the development of new antiviral drugs. A large library of benzofurazan compounds was synthesized and assayed against influenza virus A/WSN/33 (H1N1). Most of the new derivatives were found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1. Docking studies were also performed to elucidate the binding mode of benzofurazans within the PB1 binding site in PA and to identify amino acids involved in their mechanism of action. The predicted binding pose is fully consistent with the biol. data and lays the foundation for the rational development of more effective PA-PB1 inhibitors.

Different reactions of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Related Products of 67914-60-7 require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about One-pot electrochemical synthesis of highly symmetric and conjugated coumarin derivative, the main research direction is hydroxyphenyl piperazinyl ethanone hydroxy dimethylcoumarin one pot electrochem oxidation; dihydroxy phenylene bishydroxy dimethylchromenone preparation.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

A facile and one pot electrochem. synthesis of disubstituted hydroquinone generated from the electrochem. oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of 4-hydroxy-6,7-dimethylcoumarin was reported. The results revealed that p-quinone imine derived from oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone participated in Michael addition reactions with 4-hydroxy-6,7-dimethylcoumarin and followed by a hydrolysis reaction attain to the highly sym. and conjugated coumarin derivative A new product in good yield was derived based on controlled potential electrochem. oxidation at carbon electrode in a divided cell.

Different reactions of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem