Archives for Chemistry Experiments of (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

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The title aldehyde is prepared by LiAlH4 reduction of the corresponding serine derived methyl ester to the alcohol and Swern oxidation of the latter. The aldehyde is obtained in 94 % yield and 96-98 % enantiomeric purity. This method avoids some problems encountered in the synthesis of the same aldehyde by direct controlled DIBAL reduction of the ester.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2298NO – PubChem

 

The important role of (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

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A range of known and novel N-phosphoryl oxazolidinones and imidazolidinones were prepared and screened in the kinetic resolution of a range of racemic magnesium chloroalkoxides. Models are proposed to account for the enantioselectivity achieved based on a combination of chiral relay effects, generation of transient stereochemistry and the structure of the intermediate magnesium alkoxide.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2628NO – PubChem

 

Extracurricular laboratory:new discovery of (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid

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The invention concerns novel methods for preparing Combretastatin by Wittig condensation between nitromethoxy-benzaldehyde and a trimethoxybenzyl phosphonium salt or inversely a nitromethoxybenzyl phosphonium salt with trimethoxybenzylaldehyde or further by a Wittig reaction on the same derivatives whereof the nitro function has been reduced into an amino group.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2391NO – PubChem

 

Archives for Chemistry Experiments of 184346-45-0

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Application of 184346-45-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, molecular formula is C18H19NO2. In a Article,once mentioned of 184346-45-0

Dienophiles of the general structure (EtO)2P(O)CH{double bond, long}CHCOX have been prepared, where X represents an oxazolidinone chiral auxiliary. Use of the (S)-4-isopropyl-5,5-diphenyl-1,3-oxazolidin-2-one auxiliary gave Diels-Alder adducts with several cyclic and acyclic dienes. The crystal structures of the main cyclohexa-1,3-diene and 2,3-dimethylbutadiene adducts formed during reactions in the presence of dialkylaluminium halides are consistent with a reaction, which is stereoselectively endo with respect to the carbonyl group and occurs on the less hindered face of the dienophile when aluminium is chelated between the two carbonyl groups.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2626NO – PubChem

 

More research is needed about 108149-65-1

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The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2279NO – PubChem

 

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(Equation presented) Enantiomerically pure 5-acetyl-3-amino-3,4-dihydro-2H- 1-benzopyran and methyl 3-amino-3,4-dihydro-2H-1-benzopyran-5-carboxylate were successfully synthesized starting from D- or L-serine. The formation of the benzopyran ring involved a radical cyclization step. The enantiomeric purities of the final aminochroman derivatives were determined by capillary electrophoresis using beta-cyclodextrins as a chiral selector.

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Reference:
Oxazolidine – Wikipedia,
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Extended knowledge of Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 95715-86-9, name is Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, introducing its new discovery. Quality Control of Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate

Optically active acyclic N-allylamino compounds with defined configurated trisubstituted double bonds were generated via a three step sequence. The first crucial step was a two-carbon chain elongation of chiral alpha-aminoacid esters succeeding in a Claisen ester condensation with acetic acid ester enolates. The so formed beta-ketoesters were subjected to a one pot procedure of an enol trifluoromethanesulfonate generation and a consecutive palladium catalysed cross-coupling: A Stille or a Sonogashira type reaction allowed to generate selectively the trisubstituted E-olefins.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2493NO – PubChem

 

The Absolute Best Science Experiment for 145589-03-3

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 145589-03-3, in my other articles.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 145589-03-3, Name is (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, molecular formula is C15H19NO3

The present invention relates to a process and intermediates for the manufacture of aliskiren or pharmaceutically acceptable salts thereof.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2570NO – PubChem

 

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A general, mild and efficient procedure with which to access hydroxamic acids, in good yields and purity, is reported. Esters are used as substrates and reacted with hydroxylamine, in the presence of a base, under microwave activation. The method has been successfully applied to enantiomerically pure esters without loss of stereochemical integrity. Georg Thieme Verlag Stuttgart.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2535NO – PubChem

 

Some scientific research about 122709-21-1

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Synthetic Route of 122709-21-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.122709-21-1, Name is (S)-tert-Butyl 4-(methoxy(methyl)carbamoyl)-2,2-dimethyloxazolidine-3-carboxylate, molecular formula is C13H24N2O5. In a Patent,once mentioned of 122709-21-1

The present invention relates to S1P analogs that have activity as S1Preceptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and; R2 is selected from the group consisting of H, C1-C4 alkyl, (C1-C4 alkyl)OH and (C1-C4 alkyl)NH2; R23is H or C1-C4 alkyl, and R15 is a phosphonate ester or a phosphate ester or a pharmaceutically acceptable salt or tautomer thereof.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2671NO – PubChem