Tag: M.W:200-300

108149-65-1, Name is (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate, belongs to oxazolidine compound, is a common compound. Application In Synthesis of (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylateIn an article, once mentioned the new application about 108149-65-1.

PHOSPHORIBOSYLTRANSFERASE 1NHIBITORS AND USES THEREOF

The invention relates to compounds of formula (I) that are inhibitors of hypoxanthine and/or guanine purine phosphoribosyltransferases and to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and methods of treating diseases or conditions in which it is desirable to inhibit hypoxanthine and/or guanine purine phosphoribosyltransferases. Such diseases include malaria.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 108149-65-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2276NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C12H21NO5, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 95715-86-9

CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (I-A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

If you are interested in 95715-86-9, you can contact me at any time and look forward to more communication. COA of Formula: C12H21NO5

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2485NO – PubChem

 

Electric Literature of 160695-26-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 160695-26-1, Name is (R)-4-Phenyl-3-propionyloxazolidin-2-one, molecular formula is C12H13NO3. In a Article，once mentioned of 160695-26-1

Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts

A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 160695-26-1. In my other articles, you can also check out more blogs about 160695-26-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2245NO – PubChem

 

184363-66-4, Name is (S)-4-Phenyl-3-propionyloxazolidin-2-one, belongs to oxazolidine compound, is a common compound. category: oxazolidineIn an article, once mentioned the new application about 184363-66-4.

Direct alpha-siladifluoromethylation of lithium enolates with ruppert-prakash reagent via Ci-F bond activation

The direct alpha-siladifluoromethylation of lithium enolates with the Ruppert-Prakash reagent (CF3TMS) is shown to construct the tertiary and quaternary carbon centers. The Ruppert-Prakash reagent, which is versatile for various trifluoromethylation as a trifluoromethyl anion (CF3 -) equivalent, can be employed as a siladifluoromethyl cation (TMSCF2+) equivalent by Ci-F bond activation due to the strong interaction between lithium and fluorine atoms. Reaching for Ruppert-Prakash: The direct alpha-siladifluoromethylation of lithium enolates with the Ruppert-Prakash reagent (CF3TMS) is shown to construct tertiary and quaternary carbon centers (see scheme). The Ruppert-Prakash reagent can be employed as a siladifluoromethyl cation (TMSCF2+) equivalent by Ci-F bond activation due to the strong interaction between lithium and fluorine atoms.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 184363-66-4

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2262NO – PubChem

 

Electric Literature of 108149-65-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.108149-65-1, Name is (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate, molecular formula is C11H21NO4. In a Article，once mentioned of 108149-65-1

SYNTHESIS OF ACYCLIC ANALOGUES OF KAINOIDS AND NEUROEXCITATORY ACTIVITY

Four configurational isomers of 3-benzylglutamic acid, acyclic analogues of kainoids were synthesized to examine their structure-activity relationship.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 108149-65-1, and how the biochemistry of the body works.Electric Literature of 108149-65-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2321NO – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 95715-86-9, name is Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, introducing its new discovery. Formula: C12H21NO5

Total synthesis of (+)-curacin A, a marine cytotoxic agent

The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis (chiral allylborane addition, Charette cyclopropanation) to procure the various chiral fragments in enantiomerically pure form. The assembly of the natural product involves carbon-carbon bond formation (Julin coupling) and heterocycle preparation (Wipf thiazoline synthesis).

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 95715-86-9, and how the biochemistry of the body works.Formula: C12H21NO5

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2519NO – PubChem

 

Related Products of 108149-65-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.108149-65-1, Name is (S)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate, molecular formula is C11H21NO4. In a Article，once mentioned of 108149-65-1

Discovery of cytotoxic and pro-apoptotic compounds against leukemia cells: Tert-butyl-4-[(3-nitrophenoxy) methyl]-2,2-dimethyloxazolidine-3-carboxylate

Aims: We evaluated biological activity in leukemia cells lines of R and S enantiomers of tert-butyl 4-[(3-nitrophenoxy)-methyl]-2,2-dimethyloxazolidine-3- carboxylate (BNDC). Main methods: Cytotoxic activity was assessed by MTT assay. Flow cytometry assays were used to determined DNA fragmentation (Propidium Iodide-PI staining) and phosphatidylserine exposure (Annexin-V and PI staining). DNA condensation was evaluated by fluorescence microscopy using double-staining in leukemia cells (Hoechst and PI). Caspase activities were measured using Z-VAD-FMK, a non-selective caspase inhibitor, by flow cytometry and Z-DEVD-AMC, a selective caspase-3 substrate, by fluorescence spectrometry. Key findings: Both enantiomers displayed cytotoxic activity against leukemia cell lines (HL60, HL60.Bcl-2, HL60.Bcl-XL and Jurkat) with low toxicity against human peripheral blood mononuclear cell – PBMC based on IC50 values. In HL60 cell lines, compounds induce exposure of phosphatidylserine and DNA fragmentation, which could be blocked by pretreatment of cells with Z-VAD-FMK. Confirming this observation, both enantiomers induced caspase-3 activation. Additional analysis revealed an increased percentage of apoptotic cells (defined as those with fragmented nuclei and condensed chromatin) after treatment with compounds. Significance: Taken together, the results indicate that BNDC compounds exhibited cytotoxic and pro-apoptotic activities and have a potential for developing a new class of anticancer drugs.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 108149-65-1, and how the biochemistry of the body works.Related Products of 108149-65-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2313NO – PubChem

 

Synthetic Route of 95715-86-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.95715-86-9, Name is Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, molecular formula is C12H21NO5. In a Editorial，once mentioned of 95715-86-9

Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen

A new enabling technology for the pumping of organometallic reagents such as n-butyllithium, Grignard reagents, and DIBAL-H is reported, which utilises a newly developed, chemically resistant, peristaltic pumping system. Several representative examples of its use in common transformations using these reagents, including metal-halogen exchange, addition, addition-elimination, conjugate addition, and partial reduction, are reported along with examples of telescoping of the anionic reaction products. This platform allows for truly continuous pumping of these highly reactive substances (and examples are demonstrated over periods of several hours) to generate multigram quantities of products. This work culminates in an approach to the telescoped synthesis of (E/Z)-tamoxifen using continuous-flow organometallic reagent-mediated transformations.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 95715-86-9

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2541NO – PubChem

 

Related Products of 160695-26-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.160695-26-1, Name is (R)-4-Phenyl-3-propionyloxazolidin-2-one, molecular formula is C12H13NO3. In a article，once mentioned of 160695-26-1

AHU – 377 preparation method of the midbody and intermediate and intermediate preparation method (by machine translation)

The invention relates to the field of chemical synthesis, in particular to a AHU – 377 preparation method of the midbody and intermediate and intermediate preparation method. Formula (I) indicated by the AHU – 377 intermediate preparation method, the method comprising the formula (II) compound of formula (III) compounds are shown by the substitution reaction after hydrolysis of the formula (I) through the indicated by the AHU – 377 of the intermediate, the hydrolysis reaction of the hydrogen peroxide and hydrated lithium is carried out in the presence: Another purpose of this invention is to provide a novel compound, having a structure of formula (II) as shown: In the new route of the present invention, the formula (II) compound of formula (III) shown in preparation to obtain new compounds of formula (IV) as shown in the, selectivity is very good, generated during the reaction process of a very low amount of diastereoisomers, these thimbleful diastereoisomer also only needs through simple post-treatment can be removed. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 160695-26-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2234NO – PubChem

 

Electric Literature of 444335-16-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 444335-16-4, (R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one, introducing its new discovery.

A reddy handkerchief Wei preparation method and reddy handkerchief Wei intermediates (by machine translation)

The invention provides a method for the preparation of key intermediate reddy handkerchief Wei, to structure shown in the formula I compound and 2 – bromo – 7 – chloro – 9H – wuwu is initiator, to respectively obtain the structure shown as formula II compound and 2 – bromo – 7 – chloro – 9, 9 – difluoro – 9H – fluorene, through carbon – hydrogen activated coupling reaction, Suzuki coupling reaction and deprotecting reaction, to obtain the synthesis of the key intermediate reddy handkerchief Wei ? structure shown in formula VIII compound, key intermediate with the Moc – L – valine condensation reaction, can get reddy handkerchief Wei. The present invention provides the key intermediate reddy handkerchief Wei preparation method is simple, few steps, the key compound 2 – bromo – 7 – chloro – 9, 9 – difluoro – 9H – fluorene (type IV) only three-step reaction in the preparation can be obtained reddy handkerchief Wei key intermediate VIII, improves the utilization rate of the fluorine compound, the preparation cost is reduced. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 444335-16-4. In my other articles, you can also check out more blogs about 444335-16-4

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2684NO – PubChem