Some scientific research about (S)-tert-Butyl 4-(methoxy(methyl)carbamoyl)-2,2-dimethyloxazolidine-3-carboxylate

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POLYSACCHARIDE ANTIGEN-GLYCOLIPID CONJUGATE VACCINES

no abstract published

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2661NO – PubChem

 

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Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae

(Chemical Equation Presented) Two new serinolipid derivatives, shishididemniols A (1) and B (2), were isolated as antibacterial constituents of a tunicate of the family Didemnidae. The structure of 1 was elucidated by interpretation of spectral data and the application of the modified Mosher method to 1 and its suitable degradation products. Compound 2 was the chlorohydrin of 1. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2527NO – PubChem

 

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Synthetic Route of 147959-19-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.147959-19-1, Name is (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate, molecular formula is C12H21NO4. In a Article£¬once mentioned of 147959-19-1

Unified approach to the asymmetric synthesis of higher homologues of (3-quinolyl)-alanine

A new protocol based on a palladium-catalyzed Heck reaction of an amino acid-derived vinyl unit with 3-bromoquinoline has been developed to access the title compounds in good yield and optical purity. Copyright

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2335NO – PubChem

 

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COMBRETASTATIN DERIVATIVE PREPARATION METHOD

The invention relates to a method for preparing a combretastatin derivative (I) or (II), said method including the following steps: triaryl(3,4,5-trimethoxybenzyl)phosphonium halide P3 (III), wherein Ar denotes an aryl group selected from among phenyl or thienyl, is reacted with P2 having formula (IV) or P?2 having formula (V) so as to respectively obtain the compound P4 or P?4, which have formulas (VI) and (VII), respectively; then, during a step for deprotection in the presence of an acid and/or a base, the compound having P4 or P?4 leads, after an optional purification step, to the compound having formula (I) or (II).

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2355NO – PubChem

 

Simple exploration of Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate

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Modular Synthesis of Diverse Natural Product-Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12?20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the discovery of a series of macrocycles with significant antimycobacterial activity.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2510NO – PubChem

 

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Hepatitis C Virus Inhibitors

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2472NO – PubChem

 

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N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer?s disease

Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer?s disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated by acetyl-CoA and sphingosine through SphK1. N-AS then acetylates serine 565 (S565) of COX2, and the N-AS-acetylated COX2 induces the production of specialized pro-resolving mediators (SPMs). In a mouse model of AD, microglia show a reduction in N-AS generation, leading to decreased acetyl-S565 COX2 and SPM production. Treatment with N-AS increases acetylated COX2 and N-AS-triggered SPMs in microglia of AD mice, leading to resolution of neuroinflammation, an increase in microglial phagocytosis, and improved memory. Taken together, these results identify a role of N-AS in the dysfunction of microglia in AD.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2488NO – PubChem

 

Properties and Exciting Facts About (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one

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452339-73-0, Name is (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. HPLC of Formula: C13H15NO4In an article, once mentioned the new application about 452339-73-0.

PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2441NO – PubChem

 

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 95715-86-9, Name is Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, molecular formula is C12H21NO5

Cyclic peptide-polymer complexes and their self-assembly

The efficient synthesis of novel chiral cyclic peptides cy-clo[NHCHX-CH=CHCH2CO(NHCH2-CH=CHCH2CO) 2] designed to develop hydrogen-bonding interactions with suitable polymers is described. Com-plexation of a carboxylic acid derivat-ized cyclic peptide 2 (X = CH2OCOCH2CH2CO2H) capable of self-assembling as “endless” tubes, with poly(vinyl alcohol) (PVA) led to a vast weak-interaction network, in which the cyclopeptide developed extensive hydrogen-bonding interactions with the hydroxyl groups of PVA through not only the carboxylic acid, but also its ester carbonyl and amide groups. In aqueous solution, the peptide/PVA complexes self-assemble into long-grain ricelike aggregates compatible with the stacking of cyclic peptides through intercycle hydrogen bonds. Upon casting on silicon wafer, the ani-sotropic aggregates can coalesce to form filaments tens of micrometers long. The study demonstrates that complexing functionalized cyclic peptides with polymers through hydrogen bonding is a useful approach for using polymers to mediate the self-assembly and self-organization of cyclic peptides.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2491NO – PubChem

 

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Diastereoselective Electrochemical Carboxylation of Chiral alpha-Bromocarboxylic Acid Derivatives: An Easy Access to Unsymmetrical Alkylmalonic Ester Derivatives

The diastereoselective electrochemical carboxylation of chiral N-(2-bromoacyl)oxazolidin-2-ones has been studied. This reaction was carried out by cathodic reduction of the C – Br bond, in the presence of carbon dioxide, followed by treatment with diazomethane. The yields and the diastereomeric ratio of the two epimeric alkylmalonic acid derivatives are strongly affected by various factors: solvent-supporting electrolyte system, temperature, electrode material, electrolysis conditions, oxazolidinone moiety. The higher yields (88%) were obtained starting from N-(2-bromopropionyl)-4R-phenyloxazolidin-2-one la, but with poor diastereoselectivity (61:39). The two epimers were easily separated by flash chromatography. The best results were achieved using a different chiral auxiliary: Oppolzer’s camphor sultam. Starting from 1j a good yield in carboxylated product was obtained (80%) with excellent diastereoselectivity (98:2). These chiral alkylmalonic acid derivatives are valuable building blocks in the synthesis of molecules with biological activity and of chiral propane-1,3-diols derivatives.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2240NO – PubChem