Tag: M.W:300-400

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C20H20FNO4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 189028-95-3, name is (S)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. In an article，Which mentioned a new discovery about 189028-95-3

Anti-hypercholesterolemic biaryl azetidinone compounds

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with -OH, -COOH or a combination of -OH and -COOH, and R9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189028-95-3, help many people in the next few years.HPLC of Formula: C20H20FNO4

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2826NO – PubChem

 

Application of 189028-95-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.189028-95-3, Name is (S)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one, molecular formula is C20H20FNO4. In a Patent，once mentioned of 189028-95-3

One method for synthesizing intermediate folds Mai Bu (by machine translation)

The invention discloses a method for the synthesis of the intermediates folds Mai Bu , the synthesis method with compound I as the raw material, the compound is mixed with the reaction solution I, fu Suanji and under the action of the, compound I is first extra valeryl chlorine activation, then and S-4-phenyl-2-oxazolidine alkone coupling , the (R)-2-methyl-CBS-oxazole borane reduction reaction, after-treatment is the (4S)-3-[ (5S)-5-(4-fluoro phenyl)-5-hydroxy- fifth heavenly stem acyl group ]-4-phenyl -1, 3-oxygen nitrogen heterocyclic pentane-2-one (II); Wherein the reaction solution comprises tetrahydrofuran, chloroform, dioxane or dichloromethane. The invention discloses one method for synthesizing intermediate folds Mai Bu has the advantages of simple operation, the synthetic route is short, the advantages of synthetic low cost, is suitable for large-scale industrial production. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 189028-95-3

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2847NO – PubChem

 

Synthetic Route of 875444-08-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 875444-08-9, (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one, introducing its new discovery.

CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS

Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 875444-08-9. In my other articles, you can also check out more blogs about 875444-08-9

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2768NO – PubChem

 

Synthetic Route of 189028-93-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, molecular formula is C20H18FNO4. In a Patent，once mentioned of 189028-93-1

A process for the preparation of intermediates according to Mai Bu (by machine translation)

The invention discloses a method for the preparation of intermediates according to Mai Bu, the intermediate body is (S) – 1 – (4-fluoro phenyl) – 5 – (2-oxo-4-phenyl-oxazolidine-3-yl) pentane -1,5-diketone, by 1 – (4-fluoro phenyl) ethanone and silane protective agent reaction generating ((1 – (4-fluoro phenyl) vinyl) oxygen) trimethyl silane, in addition acryloyl chloride and (S) – 4-phenyl-oxazolidine-2-ketone reaction condensation to obtain (S) – 3-acryloyl-4-phenyl-oxazolidine-2-one, then the ((1 – (4-fluoro phenyl) vinyl) oxygen) trimethyl silane and (S) – 3-acryloyl-4-phenyl-oxazolidine-2-one obtained through the condensation reaction. The process route is the route convergence devices, to achieve the overall yield of 80% or more, process the raw materials is cheap and easy to obtain, with the solvent, low toxicity, production cycle is short, the production cost is cheap, simple operation the production unit, safety and environmental protection, is very suitable for industrial production. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 189028-93-1. In my other articles, you can also check out more blogs about 189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2812NO – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1676-86-4, name is (S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate, introducing its new discovery. name: (S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate

Multifunctional biocompatible and biodegradable folic acid conjugated poly(epsilon-caprolactone)-polypeptide copolymer vesicles with excellent antibacterial activities

Cancer patients after chemotherapy may also suffer bacterial attack due to badly decreased immunity. Although with high bacterial efficacy, conventional antibiotics are prone to inducement of drug resistance and may be not suitable for some cancer patients. In contrast, antibacterial peptides are highly effective in inhibiting bacteria without inducing resistance in pathogens. Presented in this article is a novel kind of highly effective antibacterial peptide-based biocompatible and biodegradable block copolymer vesicle. The copolymer is poly(epsilon-caprolactone)-block-poly[phenylalanine-stat-lysine-stat-(lysine-folic acid)] [PCL19-b-poly[Phe12-stat-Lys9-stat-(Lys-FA)6]], which can self-assemble into vesicles in aqueous solution. The biocompatible and biodegradable PCL forms the vesicle membrane, whereas the poly[Phe12-stat-Lys9-stat-(Lys-FA)6] block constitutes the vesicle coronas. Compared to the individual polymer chains, the vesicles showed enhanced antibacterial activities against both Gram-positive and Gram-negative bacteria (16 mug mL-1) due to the locally concentrated antibacterial poly[Phe12-stat-Lys9-stat-(Lys-FA)6] coronas, which may avoid the inducement of antibiotic-resistant bacteria and side effects of multidrug interactions. Furthermore, folic acid is introduced into the vesicle coronas for potential further applications such as cancer-targeted drug delivery. Moreover, the amino groups can be further functionalized when necessary. This low cytotoxic, biocompatible, biodegradable, and antibacterial vesicle (without antibiotic resistance) may benefit patients after tumor surgery because it is highly anti-inflammatory, and it is possible to deliver the anticancer drug to tumor cells simultaneously.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1676-86-4, and how the biochemistry of the body works.name: (S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2741NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. category: oxazolidine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1676-86-4

ANTIMICROBIAL COMPOSITION COMBINATIONS COMPRISING STAR SHAPED PEPTIDE POLYMERS

This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti- bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.

If you are interested in 1676-86-4, you can contact me at any time and look forward to more communication. category: oxazolidine

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2696NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C20H18FNO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, molecular formula is C20H18FNO4

According to booklet mai bu synthesis of intermediates method (by machine translation)

The invention discloses a according to the method for synthesizing intermediate folds mai bu, comprises the following steps: in under the nitrogen atmosphere, of formula (2) compound are added to in tetrahydrofuran to obtain solution A, A the solution temperature to 5 C to 10 C, and to the solution of (-) – A dropping two different pine pinane base chlorine borane, stirring the reaction, after the reaction is finished to obtain solution B, the solution B cooling to – 20 C to 0 C, aqueous solution of […], adjusting solution B of pH=5 – 8, the ethyl acetate extract adjusting pH of the solution B, evaporate ethyl acetate to obtain the residue C, to the remainder of the organic solvent is added in the C, standing, pouring the organic solvent, the residue obtained D, D to the residue in toluene is added to obtain solution E, heating and stirring solution after E, natural cooling, the solution is put into the freezing environment in E, filtering, drying formula (1) compound of the solid, the method is simple and easy, and the cost is low. The reaction is shown as follows: (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C20H18FNO4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2799NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 875444-08-9, Name is (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one, molecular formula is C12H9F6NO2

CYCLOALKENYL ARYL DERIVATIVES FOR CETP INHIBITOR

The present invention relates to cycloalkenyl aryl derivatives, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof, or solvates thereof; a method for preparing the derivatives; and pharmaceutical compositions containing the same. The compounds of the present invention show the effect of CETP activity inhibition. It means that the compounds can increase HDL-cholesterol and decrease LDL-cholesterol

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 875444-08-9, in my other articles.

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2770NO – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. Introducing a new discovery about 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

The ezetimibe intermediate and its synthetic method and the ezetimibe synthetic method (by machine translation)

The present invention provides intermediates of ezetimibe and its synthetic method and the ezetimibe synthesis method, the method of short synthetic route. The invention uses fluorobenzene as the starting material, fluorophenyl sequentially with glutaric anhydride, 4 (S)- 4 – phenyl oxazolidone acylation occurs after generating II, then 2, 2 – disubstituted – 1, 3 – propylene glycol to carbonyl compound can be obtained by protecting III, then compound III with compound IV in the titanium tetrachloride catalytic produced under the compound V, the compound V the producing the compound VI, the compound VI is hydrolyzed to compound VII, compound VII of compound soluble chiral reducing agent and hydrogenation to remove benzyl protecting group to obtain the ezetimibe. The method has high yield, less side reaction, is suitable for industrial production. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, you can also check out more blogs about189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2800NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: oxazolidine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 189028-95-3, Name is (S)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one, molecular formula is C20H20FNO4

Process For Production Of 4-Biphenylyazetidin-2-Ones

The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: oxazolidine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 189028-95-3

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2837NO – PubChem