Regioselective TfOH-mediated hydroamidation of ynamides with nitriles was written by Wang, Wan-Shu;Chen, Ping;Tang, Yu. And the article was included in Tetrahedron in 2017.Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one This article mentions the following:
Ynamides (alkynyloxazolidinones and alkynylsulfonamides) underwent regioselective and diastereoselective hydroamidation reactions with nitriles such as acetonitrile mediated by TfOH and H2O to yield (in most cases) (Z)-aminoenamides. Two of the aminoenamides were converted to oxazolidinyl pyrimidines, pyridines, and isoquinolines. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one).
3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Recommanded Product: 3-(Phenylethynyl)oxazolidin-2-one
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem