Application In Synthesis of 5-(Chloromethyl)oxazolidin-2-one, In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. 22625-57-6, Name is 5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2. In a Article，once mentioned of 22625-57-6
The synthesis of racemic Carvedilol ((±)-1) has been achieved starting from 2-(chloromethyl) oxirane ((±)-2) in a four-step sequence. 5-(Chloromethyl) oxazolidin-2-one ((±)-3) and 5-((9Hcarbazol-4-yloxy) methyl) oxazolidin-2-one ((±)-4) are intermediates. A similar sequence starting from (R)- or (S)-2-(chloromethyl)oxirane 2 give corresponding chiral 5-((9Hcarbazol-4-yloxy)methyl) oxazolidin-2-one 4 followed by chiral Carvedilol 1. The synthetic sequence followed avoids the formation of impurity B (bis impurity). This approach can be useful for the preparation of pharmaceutically important moieties containingbeta-amino alcohols without formation of bis impurity.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 22625-57-6
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1429NO – PubChem