On October 31, 2019, Zhu, Jidong; Cao, Hengyi; Sun, Lin published a patent.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Preparation of aminopyrimidine derivatives useful for the treatment of diseases associated with IDH mutation. And the patent contained the following:
The invention relates to aminopyrimidine derivatives of formula I, method for their preparation and their use for preventing and treating a disease associated with IDH mutation. Compounds of formula I, wherein A1 is a bond, CH2, CR2O, CR=CH, O, S, etc.; A2 to A10 are independently CR2, CHR, NR, O, S, etc.; B1 to B3 are independently CR and N; dotted bond is absent or double bond; R is H, halo, CN, (un)substituted C1-4alkyl, etc.; R4 and R6 are independently H, D, Me, Et, CF3, etc.; R1, R2, R3 and R5 are independently H, OH, halo, CN, etc.; D is (CH2)0-3, and their stereoisomers, racemates, pharmaceutically acceptable salts, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their isocitrate dehydrogenase 1 (IDH1) inhibitory activity. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one
The Article related to aminopyrimidine derivative preparation treatment cancer idh mutation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem